Meropenem use and colonization by antibiotic-resistant Gram-negative bacilli in a pediatric intensive care unit*

Abstract

There was no statistically detectable effect on the prevalence of colonization by Gram-negative organisms resistant to one or more classes of broad-spectrum parenteral antibiotics, or to colonization by organisms resistant specifically to meropenem, when meropenem was the preferred antibiotic in a PICU.

Nosocomial Infections and Multidrug-Resistant Bacterial Organisms in the Pediatric Intensive Care Unit

“…Although serious infection may prompt admission to the PICU, infection may also be a complication after admission has occurred [2]. Multiple sources have documented that the incidence of nosocomial infections due to antibiotic-resistant organisms is increasing, with specific examples in the Pediatric Intensive Care Unit (PICU) [3][4][5][6].…”

Pengaruh ekstrak biji pala (Myristica fragrans Houtt) sebagai antibakteri terhadap pertumbuhan Pseudomonas aeruginosa

“…Semakin lama seorang pasien mendapat terapi antibiotik, maka akan memudahkan timbulnya kolonisasi oleh mikroba yang resisten antibiotik. (5,6) Bila antibiotik diberikan berlebihan, tidak adekuat, monoton (satu jenis terus menerus) maka akan mengurangi efektifitasnya sehingga menimbulkan resistensi terutama bakteri negatif-gram. (7,8) Menurut penelitian yang telah dilakukan oleh Nurmala dkk, dikatakan bahwa bakteri negatifgram lebih banyak mengalami resistensi antibiotik dari pada bakteri positif-gram.…”

Colonization with Antibiotic-Resistant E. coli in Commensal Fecal Flora of Newborns

“…Colonization specifically by antibiotic-resistant bacilli follows a similar pattern, suggesting that such bacteria make up part of the modern NICU ecology and are acquired by infants similar to susceptible microorganisms. Although some clinically-undetected cross-transmission of resistant bacilli occurs during non-outbreak periods, most colonizing antibiotic-resistant bacilli are unique to each infant (Toltzis, 2003).…”

“…Adequate infection control practice, to limit horizontal spread of the bacteria and an early empirical antibiotic treatment effective against the causative bacteria is largely decisive for the outcome of neonatal septicemia (Toltzis, 2003).…”