MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015

Choe, Pyoeng Gyun; Perera, Ranawaka A.P.M.; Park, Wan Beom; Song, Kyoung Ho; Bang, Ji Hwan; Kim, Eu Suk; Kim, Hong Bin; Ko, Long Wei Ronald; Park, Sang Won; Kim, Nam Joong; Lau, Eric H. Y.; Poon, Leo L. M.; Peiris, Malik; Oh, Myoung Don

doi:10.3201/eid2307.170310

Cited by 234 publications

(279 citation statements)

References 17 publications

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“…Although the number of asymptomatic patients was limited to 3 in the present analysis, it is less likely that asymptomatic patients will experience seroconversion considering that even Group 1 patients with obvious MERS-related symptoms showed low seroconversion rate of 60%. This finding correlates with another serologic study that evaluated 11 rRT-PCR-confirmed MERS patients (Choe et al, 2017). In that study, antibody titers in 4 of 6 patients with mild illness were undetectable.…”

Section: Discussionsupporting

confidence: 87%

Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity

Müller

Seok

et al. 2017

Diagnostic Microbiology and Infectious Disease

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We evaluated serologic response of 42 Middle East respiratory syndrome coronavirus (MERS-CoV)-infected patients according to 4 severity groups: asymptomatic infection (Group 0), symptomatic infection without pneumonia (Group 1), pneumonia without respiratory failure (Group 2), and pneumonia progressing to respiratory failure (Group 3). None of the Group 0 patients showed seroconversion, while the seroconversion rate gradually increased with increasing disease severity (0.0%, 60.0%, 93.8%, and 100% in Group 0, 1, 2, 3, respectively; P = 0.001). Group 3 patients showed delayed increment of antibody titers during the fourth week, while Group 2 patients showed robust increment of antibody titer during the third week. Among patients having pneumonia, 75% of deceased patients did not show seroconversion by the third week, while 100% of the survived patients were seroconverted (P = 0.003).

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Section: Discussionsupporting

confidence: 87%

Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity

Müller

Seok

et al. 2017

Diagnostic Microbiology and Infectious Disease

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“…Several studies have demonstrated PCR-positive patients with mild disease often do not produce detectable levels of antibodies, particularly when followed past the acute phase of the disease. 44…”

Section: Histopathologic Featuresmentioning

confidence: 99%

Emerging respiratory infections: The infectious disease pathology of SARS, MERS, pandemic influenza, and Legionella

Bradley

Bryan

2019

Seminars in Diagnostic Pathology

112

126

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A B S T R A C TLower respiratory infections remain one of the top global causes of death and the emergence of new diseases continues to be a concern. In the first two decades of the 21st century, we have born witness to the emergence of newly recognized coronaviruses that have rapidly spread around the globe, including severe acute respiratory syndrome virus (SARS) and Middle Eastern respiratory syndrome virus (MERS). We have also experienced the emergence of a novel H1N1 pandemic influenza strain in 2009 that caused substantial morbidity and mortality around the world and has transitioned into a seasonal strain. Although we perhaps most frequently think of viruses when discussing emerging respiratory infections, bacteria have not been left out of the mix, as we have witnessed an increase in the number of infections from Legionella spp. since the organisms' initial discovery in 1976. Here, we explore the basic epidemiology, clinical presentation, histopathology, and clinical laboratory diagnosis of these four pathogens and emphasize themes in humans' evolving relationship with our natural environment that have contributed to the infectious burden. Histology alone is rarely diagnostic for these infections, but has been crucial to bettering our understanding of these diseases. Together, we rely on the diagnostic acumen of pathologists to identify the clinicopathologic features that raise the suspicion of these diseases and lead to the early control of the spread in our populations. (A. Bryan). Seminars in DiagnosticPathology 36 (2019) 152-159 0740-2570/

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“…Asymptomatic individuals were less likely to have underlying condition (42%) compared to 86% of fatal cases [45]. However, serologic evaluation of contacts and patients may underestimate the extent of the disease as antibodies wane over time and is related to disease severity [46]. Of particular interest is that most of the identified pediatric cases were asymptomatic with no clear explanation [38][39][40]47].…”

Section: Extent Of Asymptomatic Mers In Humansmentioning

confidence: 99%

Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: Extent and implications for infection control: A systematic review

Al‐Tawfiq

Gautret

2019

Travel Medicine and Infectious Disease

101

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Background: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) emerged in 2012 and attracted an international attention as the virus caused multiple healthcare associated outbreaks. There are reports of the role of asymptomatic individuals in the transmission of MERS-CoV, however, the exact role is not known. Method: The MEDLINE/PubMed and Scopus databases were searched for relevant papers published till August 2018 describing asymptomatic MERS-CoV infection.Results: A total of 10 papers were retrieved and included in the final analysis and review. The extent of asymptomatic MERS infection had increased with change in the policy of testing asymptomatic contacts. In early cases in April 2012-October 2013, 12.5% were asymptomatic among 144 PCR laboratory-confirmed MERS-CoV cases while in 2014 the proportion rose to 25.1% among 255 confirmed cases. The proportion of asymptomatic cases reported among pediatric confirmed MERS-CoV cases were higher (41.9%-81.8%). Overall, the detection rate of MERS infection among asymptomatic contacts was 1-3.9% in studies included in this review. Asymptomatic individuals were less likely to have underlying condition compared to fatal cases. Of particular interest is that most of the identified pediatric cases were asymptomatic with no clear explanation.Conclusions: The proportion of asymptomatic MERS cases were detected with increasing frequency as the disease progressed overtime. Those patients were less likely to have comorbid disease and may contribute to the transmission of the virus. * Corresponding author.

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MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015

Cited by 234 publications

References 17 publications

Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity

Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity

Emerging respiratory infections: The infectious disease pathology of SARS, MERS, pandemic influenza, and Legionella

Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: Extent and implications for infection control: A systematic review

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