MERS-CoV‒Specific T-Cell Responses in Camels after Single MVA-MERS-S Vaccination

Natrup, Christian Meyer zu; Schünemann, Lisa-Marie; Saletti, Giulietta; Clever, Sabrina; Herder, Vanessa; Joseph, Sunitha; Rodrı́guez, M.; Wernery, Ulrich; Sutter, Gerd; Volz, Asisa

doi:10.3201/eid2906.230128

Cited by 1 publication

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“…Their evolutionary progression can be categorized into three stages: animal-only, zoonotic, and human-specific viruses. Recent outbreaks of SARS-CoV in 2003 [65,176,177] and MERS-CoV in 2012, which originated in bats, have demonstrated that the virus can only infect humans through the evolution and adaptation of intermediate hosts, such as civets and camels [178,179]. Predicting the possible mutation sites of SADS-CoV is crucial for understanding its potential evolution and assessing the risk of its transmission to humans.…”

Section: Discussionmentioning

confidence: 99%

Research Advances on Swine Acute Diarrhea Syndrome Coronavirus

Liu,

Huang,

et al. 2024

Animals

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Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a virulent pathogen that causes acute diarrhea in piglets. The virus was first discovered in Guangdong Province, China, in 2017 and has since emerged in Jiangxi, Fujian, and Guangxi Provinces. The outbreak exhibited a localized and sporadic pattern, with no discernable temporal continuity. The virus can infect human progenitor cells and demonstrates considerable potential for cross-species transmission, representing a potential risk for zoonotic transmission. Therefore, continuous surveillance of and comprehensive research on SADS-CoV are imperative. This review provides an overview of the temporal and evolutionary features of SADS-CoV outbreaks, focusing on the structural characteristics of the virus, which serve as the basis for discussing its potential for interspecies transmission. Additionally, the review summarizes virus–host interactions, including the effects on host cells, as well as apoptotic and autophagic behaviors, and discusses prevention and treatment modalities for this viral infection.

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