Merthiolate: A tissue preservative and antiseptic

O'Connor, Gerald Brown

doi:10.1016/s0002-9610(39)90482-4

Cited by 19 publications

(5 citation statements)

References 5 publications

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“…Morgan, Jamieson and Powell (1933) reported the use of merthiolate solution as a preservative. O'Connor in 1939, and Brown and De Mere (1948) preserved cartilage in merthiolate.…”

Section: Figmentioning

confidence: 99%

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Experiences with a Merthiolate Bone Bank

Arden

1956

Int J Clinical Practice

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“…Morgan, Jamieson and Powell (1933) reported the use of merthiolate solution as a preservative. O'Connor in 1939, and Brown and De Mere (1948) preserved cartilage in merthiolate.…”

Section: Figmentioning

confidence: 99%

“…Morgan,jamieson and Powell (1933 ) reported the use ofmerthiolate solution as a preservative. O'Connor in 1939, andBrown andDe Mere (1948) preserved cartilage in merthiolate. Reynolds and Oliver (1949) compare merthiolate preserved homogenous grafts with frozen and boiled homogenous grafts as well as with autogenous grafts.…”

mentioning

confidence: 99%

Experiences with a Merthiolate Bone Bank

Arden

1956

Int J Clinical Practice

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“…As reported by Khazaei and colleagues [2], thiophenols find application in the production of pharmaceuticals, including sulfonamides. Examples of common drugs derived from thiophenols include the antipsychotic agent Thioridazine [4], the antifungal Butoconazole [5], the anthelmintic Albendazole [6], and the old (1939s) antiseptic Merthiolate [7]. Also, noteworthy applications in material science include the use of substituted benzenethiols in molecular electronics, surface-enhanced Raman spectroscopy, and quantum electronic tunneling between plasmonic nanoparticle resonators [8].…”

Section: Introductionmentioning

confidence: 99%

Bond analysis in meta- and para-substituted thiophenols: overlap descriptors, local mode analysis, and QTAIM

Barbosa,

Santos-,

Andrade

et al. 2024

J Mol Model

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Context: This study delves into the chemical nuances of thiophenols and their derivatives through a comprehensive computational analysis, moving beyond traditional energetic perspectives such as bond dissociation enthalpy and S−H dissociation dynamics. By employing the overlap model along with its topological descriptors (OP/TOP), Quantum Theory of Atoms in Molecules (QTAIM), and Local Vibrational Mode (LVM) theories, the research provides a deeper understanding of the S−H and C−S bonding scenarios in substituted thiophenols. The investigation follows the electron-donating capacity of S−H substituent variation with the nature and positioning of other ring substituents. Energy profile analyses indicate distinct stability differences in the cis and trans conformations of meta-and para-PhSH systems, influenced by the electron-donating strength of these substituents. The study also uncovers significant variations in S−H bond distances and descriptor values, particularly in para-substituted PhSH, reflecting the influence of electron-donating or withdrawing substituents. In contrast, alterations at the meta-position show minimal effects on C−S bond descriptors, while para-substitutions markedly influence C−S bond characteristics, demonstrating a clear correlation with the electron-donating or withdrawing capabilities of the substituents. This research sheds light on the intricate bond dynamics in aromatic systems with diverse substituents, highlighting the complex interaction between electronic effects and molecular conformation. Methods: The study employs the ωB97X-D/Def2TZVP level of theory for molecular geometries, ensuring accurate characterization of structures as true minima via analytical harmonic frequency determination. The electronic properties of S−H and C−S bonds in variously substituted thiophenols were analyzed using OP/TOP, QTAIM, and LVM methodologies. Computational processes, including conformational scans, geometry optimizations, and vibrational frequency calculations, were conducted using Gaussian 09, with ultra-fine integration grids and tight convergence criteria for the SCF procedure. Bond descriptors were computed utilizing ChemBOS, Multiwfn, and LModeA software, providing a robust and detailed examination of bond properties. Chemical bond overlap densityElectron-donating group Electron-withdrawing group

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“…Thiophenolates, the conjugate bases derived from thiophenols, form strong complexes with many metal ions, 4 especially those classified as soft, and make polymeric metal cations from thiophenolates. 5 Thioridazine (an antipsychotic and neuroleptic agent), 6 butoconazole (antifungal), 7 azathioprine (prevent organ rejection agent following organ transplantation), 8 albendazole (worm treatment), 9 merthiolate (antiseptic and antifungal agent), 10 and riluzole (treat amyotrophic lateral sclerosis) 11 are some of the common drugs which are derived from thiophenols. The organosulfur medicines like sulfonamides are also prepared from thiophenols.…”

mentioning

confidence: 99%

Novel One-Pot Synthesis of Thiophenols from Related Triazenes under Mild Conditions

Khazaei

Kazem‐Rostami

Moosavi‐Zare

et al. 2012

Synlett

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In this work, at first, triazenes were synthesized from primary aryl amines. Afterwards, triazenes were converted into the corresponding thiophenols in one-pot using sodium sulfide in acidic media, by in situ generation of diazonium counterion beside hydrogen sulfide as anionic sulfur nucleophile at room temperature. The procedure can be a convenient shortcut for the preparation of thiophenols from primary aryl amines.

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Merthiolate: A tissue preservative and antiseptic

Cited by 19 publications

References 5 publications

Experiences with a Merthiolate Bone Bank

Experiences with a Merthiolate Bone Bank

Bond analysis in meta- and para-substituted thiophenols: overlap descriptors, local mode analysis, and QTAIM

Novel One-Pot Synthesis of Thiophenols from Related Triazenes under Mild Conditions

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