The Mesa Virgen Calerilla (MVC) is located in the state of Zacatecas, Mexico. The most intense volcanism, which occurred during the Eocene, formed extensive ignimbrite deposits exposed in some parts as lava spills of rhyolitic (felsic) composition. This felsic volcanism may represent much of the MVC. This study describes wholerock geochemistry and mineralogy data from felsic volcanic rocks in the MVC to address their petrogenesis and tectonic setting. The MVC covers a compositional spectrum ranging from trachyte, dacite, to high-silica rhyolite. The petrography and mineral assemblages indicate that the felsic rocks are composed of K-feldspar (sanidine), quartz, plagioclase, and biotite. The felsic volcanic rocks have a composition of 64.08-78.17 wt% (SiO 2 ) adj , 0.14-0.69 wt% (TiO 2 ) adj , and 0.11-0.62 wt% (MgO) adj with 12-54 Mg number [Mg# = 100 × (Mg 2+ /[Mg 2+ + Fe 2+ ])]. These felsic volcanic rocks showed enrichment in light rare earth elements (LREE; [La/ Sm] N = 3.80-7.19), and are depleted in heavy rare earth elements [HREE; (Tb/Yb) N ratios 0.35-1.84], along with negative Ba, Nb, Sr, P, Eu, and Ti anomalies. The geochemical characteristics and petrogenetic modelling indicate that felsic volcanic rocks are derived from partial melting process of an upper-middle continental crust. The tectono-magmatic model and multidimensional tectonic discrimination diagram indicate that an extensional-related setting prevails for the MVC.