Mesalazine-induced interstitial nephritis in a patient with ulcerative colitis

Gorospe, Emmanuel C.; Leggett, Cadman L.

doi:10.1136/bcr.12.2011.5351

Cited by 5 publications

(1 citation statement)

References 3 publications

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“…Insbesondere durch Leflunomid induzierte interstitielle Nephritiden sind in Einzelfallberichten publiziert worden [20,39]. Bei chronisch-entzündli-chen Darmerkrankungen gibt es ebenfalls Berichte, die 5-Aminosalicylate (Mesalazin und Sulfasalazin) als Auslöser diskutieren [16,49], wobei Mesalazin deutlich häufiger ursächlich zu sein scheint [45]. Unklar ist hier die Kausalitätsbeziehung, da die interstitielle Nephritis auch eine extraintestinale Manifestation bei Morbus Crohn darstellen kann [9].…”

Section: » Rheumatologischeunclassified

Interstitielle Nephritis bei rheumatischen Erkrankungen

Korsten

Müller

2015

Z Rheumatol

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Interstitial nephritis is responsible for about 12 % of end-stage renal disease in Germany. It comprises an etiologically heterogenous group of inflammatory renal disorders which primarily affect the renal interstitium and tubuli. Drugs, predominantly antibiotics, nonsteroidal anti-inflammatory drugs and proton pump inhibitors are causative in the majority of cases. Rheumatic diseases frequently affect the kidneys, either the glomeruli or the interstitial tissues. Inflammatory interstitial processes can be accompanied by complex functional tubular disorders. This review gives an overview about clinical and laboratory findings of interstitial nephritis in the context of rheumatic diseases. Sarcoidosis, tubulointerstitial nephritis and uveitis (TINU) syndrome, primary Sjogren's syndrome, and IgG4-related disease often show an interstitial nephritis when the kidneys are affected. Other diseases, such as systemic lupus erythematosus, systemic sclerosis, drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, and granulomatosis with polyangiitis are more rarely associated with predominant interstitial nephritis. Glucocorticoids are the mainstay of therapy for most cases; in refractory cases or when side effects occur, second-line immunosuppressants such as mycophenolate mofetil, azathioprine and others, rarely biologics, can be used.

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