Mescaline-induced changes of brain cortex ribosomes. effect of mescaline on amino acid incorporating ability of ribosomes

Datta, R. K.; Ghosh, J. J.

doi:10.1016/0006-8993(71)90317-9

Brain Research

1971

DOI: 10.1016/0006-8993(71)90317-9

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Mescaline-induced changes of brain cortex ribosomes. effect of mescaline on amino acid incorporating ability of ribosomes

R. K. Datta

J. J. Ghosh

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1973

1977

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Mescaline-induced changes of brain-cortex ribosomes mescaline demethylase activity of brain-cortex soluble supernatant

Datta

Ghosh

1977

Naunyn-Schmiedeberg's Arch. Pharmacol.

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Brain-cortex slices demethylate mescaline and p-methoxyacetanilide, a reference O-demethylating substrate, though the rate of demethylation of mescaline is about one third that of the reference substrate. The demethylase activity is localized mostly in the soluble supernatant (105 000 x g). It is purified 47-fold with respect to the demethylation of mescaline by ammonium sulfate precipitation and DEAE cellulose chromatography. The partially purified demethylase, which is stable for 3-5 days at -5 degrees C in the presence of dithiothreitol and glutathione and is inhibited by p-chloromercuribenzoate, has maximal activity at pH between 7.2 and 8.0. It demethylates mescaline into 3,4-dimethoxy-5-hydroxyphenethylamine and 3,5-dimethoxy-4-hydroxyphenethylamine and some unidentified derivatives.

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Mescaline-induced changes of brain-cortex ribosomes mescaline demethylase activity of brain-cortex soluble supernatant

Datta

Ghosh

1977

Naunyn-Schmiedeberg's Arch. Pharmacol.

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show abstract