Mesenchymal chondrosarcoma of the jaws

Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and β-catenin, Sox9, and osteocalcin immunostaining of 22 cases

“…The presence of calcifications by imaging or gross pathology or endochondral ossification in mesenchymal chondrosarcoma by microscopic analysis has been previously mentioned in the literature ( [2,[4][5][6]11], refer to discussion of β-catenin later), and it is helpful to note that the calcification can be observed on imaging for this tumor.…”

“…Mesenchymal chondrosarcoma, a rare high-grade malignant tumor of purported cartilage phenotype [1][2][3][4][5], is predominantly intraosseous [2,6,7]; extraskeletal sites are rare, yet brain and spinal cord are the most common extraskeletal locations [3,[8][9][10][11]. Histologically, mesenchymal chondrosarcoma has a characteristic biphasic pattern composed of a cellular poorly differentiated small round blue cell component interspersed with islands of well-differentiated hyaline cartilage.…”

Chondrosarcoma of the Jaw

“…Chondrosarcoma is the malignant counterpart of chondroma, 2 which occur equally in males and females, 5 but preferentially in males, 6 and it may have a 2:1 male-to-female ratio. 7 Maxillary and mandibular localizations are extremely rare and have poor prognosis, 1 and the ratio is 2:1.…”

“…7 Maxillary and mandibular localizations are extremely rare and have poor prognosis, 1 and the ratio is 2:1. 7 They occur in the second and third decades 6 and in the sixth and seventh decades of life. 5 More than half of the patients aged between 20 and 50 years.…”

Huge Mesenchymal Chondrosarcoma of Mandible

“…It was first described by Lichtenstein and Bernstein in 1959 as a distinct variant of chondrosarcoma from which it must be differentiated [2]. It usually appears in second and third decade of life [2].…”