Mesenchymal Hamartoma of Chest Wall in Infancy Natural History of Two Cases

Abstract

Two cases of mesenchymal hamartoma of chest wall in infancy are reported. These distinctive and rare lesions arise in the antenatal period, present at birth or in early life as chest wall masses with marked rib deformation, and may produce respiratory compromise through encroachment on the chest cavities. Histologically composed of chondroid and primitive mesenchymal elements with giant-cell formation, endochondral ossification, and maturation to trabecular bone, they exhibit some features of aneurysmal bone cyst. Because of their cellularity and proliferative appearance, they are often misinterpreted as sarcomas; however, they pursue a benign course and can be well managed surgically. Our cases possessed multiple chest wall masses that were clinically apparent at birth and sequentially resected over a period of several months, creating an opportunity to document their hitherto unreported histologic evolution. Their pattern of maturation is in keeping with a hamartomous malformation.

Mesenchymal (chondromatous) hamartoma of chest wall in a neonate: A case report and review of literature

“…This name best reflects the benign nature and multiple histologic component of this lesion. 1 MHCW is not a true neoplasm and is composed of maturing, proliferating and normal skeletal elements 11,12,13 , with no propensity for invasion or metastasis. 2 The natural history is not well understood.…”

Hamartoma mesenquimatoso de la pared torácica: presentación de un caso

“…Fue descrito por primera vez en 1962, como un tumor mesodérmico benigno que se origina en las costillas (2). Se han usado varios términos para denominarlo: hamartoma de la pared torácica, hamartoma condromatoso gigante, hamartoma cartilaginoso y hamartoma cartilaginoso vascular.…”

“…Se han usado varios términos para denominarlo: hamartoma de la pared torácica, hamartoma condromatoso gigante, hamartoma cartilaginoso y hamartoma cartilaginoso vascular. En la década de los 80 se usaba preferentemente el término mesenquimoma, hasta 1986, cuando Odell y Benjamin empezaron a llamarlo hamartoma mesenquimatoso de la pared torácica, término actualmente más aceptado (2 carogldm@hotmail.com manifiestan antes del primer año de vida por la presencia de masa visible sobre la pared torácica; sin embargo, hasta 60% pueden ser asintomáticos (4). Los síntomas respiratorios son secundarios a la compresión extrínseca sobre el parénquima pulmonar y su gravedad depende del tamaño y la localización de la lesión (5).…”

“…El hamartoma mesenquimatoso de la pared torácica se caracteriza por tener un crecimiento progresivo; sin embargo, puede presentar regresión espontánea o, menos frecuentemente, sufrir una trasformación maligna (2). Habitualmente, el crecimiento se detiene cerca del primer año de vida, lo que hace innecesario el tratamiento quirúrgico en la mayoría de los casos (9).…”

Cytohistomorphological identification of congenital bilateral mesenchymal hamartoma of chest wall

“…It was first described as intrathoracic mesenchymoma [2] which was later on replaced by hamartoma due to its benign nature [3,4] . It generally comprise of mixture of cartilaginous component, fibrous tissues and cystic cavities.…”