Mesenchymal hamartoma of liver in a man: comparison with cases in infants.

Abstract

A 53 year old man with a large mesenchymal hamartoma is reported. Only a few bile ducts could be found in the periphery of the lesion and no hepatocytes were identified within the lesion. As far as is known, this is the only adult male patient reported to date. On the basis of the reported findings of mesenchymal hamartoma in other adults, it is suggested that there could be changes in the morphology of this lesion with age: progressive loss of hepatocytes; degeneration of bile duct epithelium; and cystic change of the mesenchymal component. The haematopoietic element is considered to be part of the fetal hepatic haematopoiesis that occurs in the hamartoma.

Mesenchymal hamartoma of the liver in adults: Case report

“…Since the appearance of tumor can vary from cystic to completely solid mass as well as a combination of both components, there is no consensus on which form of tumor is more common. Some authors have reported results which show higher frequency of cystic form in children [2], whereas others claim quite the opposite, that is they have found a higher frequency of solid mass tumor in pediatric age group [5]. The situation with adult patients is similar.…”

“…The situation with adult patients is similar. Chau et al [5] have reported higher frequency of cystic tumors, and Hernandez et al [9] have recorded higher frequency of cystic tumors in both adult and pediatric patients. It is believed that women are more prone to developing cystic tumors, and for men there is no tendency to any kind of tumor.…”

“…Concerning localization and structure, pediatric and adult populations have different characteristics. Mesenchymal hamartoma of the liver is more common in the left liver lobe in children, while in adults it is equally common in the left (about 40%) and the right lobe of liver (40%), and in about 20% of cases, tumor is in both lobes [5]. It has been noticed that mesenchymal hamartoma of the liver in male patients is more common in the right lobe, while in women it is more common in the left lobe of liver, and cases when the tumor is in both lobes is more frequent in women.…”

Fine Needle Aspiration Cytology of Mesenchymal Hamartoma of the Liver

“…It has been reported to occur in adults. 2,[5][6][7] The male: female ratio is 3 : 1, 8 and the tumor usually presents clinically as an abdominal swelling.…”

Solid mesenchymal hamartoma in an adult: a case report

“…Under 20 adult cases have been reported. [12][13][14][15][16][17][18][19][20][21][22][23][24] In all of these, there have been clear differences compared with the manifestations of the disease in childhood.…”