2022
DOI: 10.3389/fncel.2022.898497
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Mesenchymal Stem Cell Application and Its Therapeutic Mechanisms in Intracerebral Hemorrhage

Abstract: Intracerebral hemorrhage (ICH), a common lethal subtype of stroke accounting for nearly 10–15% of the total stroke disease and affecting two million people worldwide, has a high mortality and disability rate and, thus, a major socioeconomic burden. However, there is no effective treatment available currently. The role of mesenchymal stem cells (MSCs) in regenerative medicine is well known owing to the simplicity of acquisition from various sources, low immunogenicity, adaptation to the autogenic and allogeneic… Show more

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Cited by 16 publications
(12 citation statements)
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“…Another strategy to improve the MSCs’ effectiveness is to facilitate the ways of their cryopreservation. More specifically, freshly thawed MSCs following cryopreservation stunted functional characteristics, including the upregulation of metabolic activity and apoptosis and downregulation of cell proliferation, immunosuppressive capabilities, clonogenic capacity, and critical regenerative genes [ 14 , 186 , 187 ]. Notably, a 24-hour acclimation period reactivated the thawed cells, diminishing apoptosis and enhancing the high-mobility group box (HMOX-1) and tumor necrosis factor-stimulated gene-6 (TSG-6) genes expression with anti-inflammatory effects and VEGF gene expression with angiogenic effects [ 186 ].…”
Section: Hopeful Strategies Have the Potential To Improve The Mscs Ef...mentioning
confidence: 99%
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“…Another strategy to improve the MSCs’ effectiveness is to facilitate the ways of their cryopreservation. More specifically, freshly thawed MSCs following cryopreservation stunted functional characteristics, including the upregulation of metabolic activity and apoptosis and downregulation of cell proliferation, immunosuppressive capabilities, clonogenic capacity, and critical regenerative genes [ 14 , 186 , 187 ]. Notably, a 24-hour acclimation period reactivated the thawed cells, diminishing apoptosis and enhancing the high-mobility group box (HMOX-1) and tumor necrosis factor-stimulated gene-6 (TSG-6) genes expression with anti-inflammatory effects and VEGF gene expression with angiogenic effects [ 186 ].…”
Section: Hopeful Strategies Have the Potential To Improve The Mscs Ef...mentioning
confidence: 99%
“…Then, MSCs have been found to differentiate into several other mesenchymal tissues, such as myocytes and adipocytes [ 7 , 8 ]. Further investigations revealed that MSCs could differentiate into different lineages, including epithelial, neuronal, astrocytic morphology, endothelial, and smooth muscle in vitro, depending on specific conditions of cocultured cell type [ 9 14 ]. Meanwhile, Dazzi et al and Taechangam et al suggested that the multipotent capacity, support of hematopoiesis in the BM, and their immunoregulatory effects positively endow MSCs treatment as a promising therapeutical strategy [ 15 , 16 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Intracerebral hemorrhage (ICH) is a destructive disease because of its increased mortality and morbidity rates, accounting for nearly 10%–20% of stroke cases worldwide (Dasari et al, 2021 ; Liu et al, 2022 ; Yang et al, 2022 ). After ICH, vessel rupture of brain parenchyma contributes to the aggregation of red blood cells (RBCs) and the formation of hematoma to oppress brain tissue structure forming primary brain injury (PBI).…”
Section: Introductionmentioning
confidence: 99%