Mesenchymal Stem Cell-based Scaffolds in Regenerative Medicine of Dental Diseases

Kiarashi, Mohammad; Bayat, Hannaneh; Shahrtash, Seyed Abbas; Etajuri, Enas Abdalla; Khah, Meysam Mohammadi; AL-Shaheri, Nadhim Allawi; Nasiri, Kamyar; Esfahaniani, Mahla; Yasamineh, Saman

doi:10.1007/s12015-024-10687-6

Cited by 12 publications

(2 citation statements)

References 148 publications

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“…This conclusion was not achieved by our study, but adding a control group would add the data whether these results is are also present among patients with severe MS or not (13)(14)(15). In patients who are making their first visit, specialists should be consulted to discuss various aspects of their health status (16,17). Their generality, including that are unclear to the doctor, should be clarified after reviewing the records or conducting a physical examination (18).…”

Section: Resultsmentioning

confidence: 79%

Serum 25(OH)D Levels and Mitral Valve Calcification in Patients with Severe Rheumatic Mitral Stenosis

Rahmani,

Kavoosi,

Sadeghi

et al. 2024

CJMS

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Background: Rheumatic heart disease (RHD) imposes a significant burden on patients and the health system, especially in the developing countries. Recently, the role of vitamin D deficiency in increasing the severity of valve involvement and calcification in patients with RHD has been suggested. However, its role in the severe stenosis of the mitral valve is unknown. The aim of this study was to determine the relationship between serum levels of 25(OH)D and mitral involvement severity scores in patients with severe mitral stenosis (MS). Materials and Methods: In this cross-sectional study conducted in Shahid Madani Heart Center, Tabriz, Iran, 104 patients with severe rheumatic MS were reviewed, in the absence of other underlying diseases. Trans-esophageal Echocardiography was performed for all patients, and mitral valve Wilkins score and mitral valve area were calculated. Blood samples were taken from patients and levels of 25(OH)D, total calcium, phosphorus, and i-PTH were measured. Results: Eighty eight cases were female and 16 were male. Eighty-one patients had mild to moderate mitral calcification and in 23 patients with mitral valve was severely calcified. Furthermore, 54 were vitamin D deficient, while 35 had insufficient vitamin D levels, and only 15 had normal blood levels of vitamin D. In addition high serum iPTH levels were present in 83 patients (80%). The levels of 25(OH)D, calcium, phosphorous, and iPTH with total Wilkins score, calcification score and mitral valve area were not significantly correlated (p>0.05 for all above). Conclusions: Although no correlation was found between the severity of mitral valve involvement, and vitamin D and iPTH levels, vitamin D deficiency and secondary hyperparathyroidism tend to be common among patients with severe rheumatic MS, which may play a role in the progression of the disease.

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Section: Resultsmentioning

confidence: 79%

Serum 25(OH)D Levels and Mitral Valve Calcification in Patients with Severe Rheumatic Mitral Stenosis

Rahmani,

Kavoosi,

Sadeghi

et al. 2024

CJMS

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“…Also, It is necessary to check the patient's condition, medications and underlying disease before prescribing. Abuse of benzodiazepines usually involves co-administration with other drugs, alcohol, and/or other illicit substances, which Patients who visit medical professionals do not always report their past medical history, either because they do not consider it important or because they do not consider it relevant to their problem (28)(29)(30). Adequate medical training and taking a detailed medical history, which should include the patient's past medical and drug history and checking the general health status, are necessary to identify patients with related medical conditions and prevent the resulting risks in choosing treatment (31,32).…”

Section: Discussionmentioning

confidence: 99%

The Effect of N-acetylcysteine on Alprazolam Withdrawal Symptoms in Wistar Male Albino Rats

Marvast,

Amnieh,

Navabazam

et al. 2024

CJMS

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Introduction: Alprazolam is a benzodiazepine drug that is mainly used to treat generalized anxiety disorder and sleep disorders. Doctors' insistence on prescribing alprazolam due to its long half-life (16 hours) can lead to severe withdrawal complications. The aim of this study was to evaluate the effect of N-acetylcysteine (NAC) as an antioxidant drug on reducing the withdrawal symptoms of alprazolam in male albino rats. Material and Methods: In this experimental study, 50 albino male Wistar rats were used. 10 rats received normal saline by gavage for 26 days (sham), the rest of the rats received 1 mg / kg of alprazolam daily for 21 days and after drug dependence were randomly divided into 4 groups were divided. The negative control group received normal saline by gavage daily for up to 4 days after the dependence period. The treated groups also received 100, 200, and 400 mg / kg NAC orally for 4 days after the dependence period, after which the anti-anxiety and restless effects of N-acetylcysteine were assessed by behavioral test (Elevated plus-maze test). Results: The variables OAE (p = 0.18), CAE (p = 0.88), CAT (p = 0.53) and OAT percent (p = 0.29) did not show a significant difference between the 5 treatment groups; But OAT (p = 0.07) and OAE_percent (p = 0.001) showed a significant difference between the 5 treatment groups (p <0.05). Conclusion: Due to the antioxidant properties of NAC and its ability to counteract oxidative stress in the nervous system, it can be used to control the symptoms of withdrawal syndrome in people with a history of alprazolam dependence. In the present study, a dose of 400 mg / kg NAC had the best therapeutic effects in rats. In future studies, it is recommended to obtain an appropriate dose for people who experience symptoms of alprazolam withdrawal syndrome.

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The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage

Rostami,

Farahani,

Esmaelian

et al. 2024

Stem Cell Rev and Rep

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Mesenchymal Stem Cell-based Scaffolds in Regenerative Medicine of Dental Diseases

Cited by 12 publications

References 148 publications

Serum 25(OH)D Levels and Mitral Valve Calcification in Patients with Severe Rheumatic Mitral Stenosis

Serum 25(OH)D Levels and Mitral Valve Calcification in Patients with Severe Rheumatic Mitral Stenosis

The Effect of N-acetylcysteine on Alprazolam Withdrawal Symptoms in Wistar Male Albino Rats

The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage

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