Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice

Yue, Rongchuan; Lu, Shengzhong; Luo, Yu; Jing, Zeng; Liang, Hao; Qin, Dan; Wang, Xiaobo; Wang, Tao; Pu, Jun; Hu, Houxiang

doi:10.1038/s41420-022-00909-6

Cited by 47 publications

(30 citation statements)

References 64 publications

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“…In addition, MSCs have exhibited the highest amount of CD81 expressed exosomes. , It has been shown that upregulated miRNAs, especially miR-320C, from MSC-derived exosomes promote osteoarthritis chondrocyte proliferation. In a myocardial I/R injury study, MSC-derived exosomes carrying miR-182-5p showed a cardioprotective effect with improving cardiac function and reducing myocardial infarction, accompanied with reduced inflammation in vivo . Exosomes from mesenchymal stem cells play an important role in many diseases and can be used as an adjuvant in supporting and complementing other therapeutic modalities.…”

Section: Applications Of Exosomesmentioning

confidence: 99%

Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics

et al. 2022

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Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer membrane and secreted by most eukaryotic cells. They represent a route of intercellular communication and participate in a wide variety of physiological and pathological processes. The biological roles of exosomes rely on their bioactive cargos, including proteins, nucleic acids, and lipids, which are delivered to target cells. Their distinctive properties�innate stability, low immunogenicity, biocompatibility, and good biomembrane penetration capacity�allow them to function as superior natural nanocarriers for efficient drug delivery. Another notably favorable clinical application of exosomes is in diagnostics. They hold various biomolecules from host cells, which are indicative of pathophysiological conditions; therefore, they are considered vital for biomarker discovery in clinical diagnostics. Here, we use data from the CAS Content Collection and provide a landscape overview of the current state and delineate trends in research advancement on exosome applications in therapeutics and diagnostics across time, geography, composition, cargo loading, and development pipelines. We discuss exosome composition and pathway, from their biogenesis and secretion from host cells to recipient cell uptake. We assess methods for exosome isolation and purification, their clinical applications in therapy and diagnostics, their development pipelines, the exploration goals of the companies, the assortment of diseases they aim to treat, development stages of their research, and publication trends. We hope this review will be useful for understanding the current knowledge in the field of medical applications of exosomes, in an effort to further solve the remaining challenges in fulfilling their potential.

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Section: Applications Of Exosomesmentioning

confidence: 99%

Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics

et al. 2022

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“…Liu et al illustrated that cardiac fibroblast-derived exosomes carry microRNA-133A to suppress cardiomyocyte pyroptosis in myocardial I/R injury, and Zhang et al indicated that hypoxic cardiac microvascular endothelial cell-derived exosomes carry microRNA-27b-3p to alleviate myocardial I/R Injury via the Foxo1/GSDMD signaling pathway [ 74 , 75 ]. Similar to their functions in cerebral I/R injury, the exosomes of mesenchymal stem cells can also mitigate myocardial I/R injury through inhibiting the canonical pathway of pyroptosis [ 76 , 77 ]. In addition, by targeting the Akt/GSK3β/NF-κB pathway, aesculin can inhibit NLRP3 inflammasome-mediated pyroptosis and thereby attenuate myocardial I/R injury [ 78 ].…”

Section: Pyroptosis and I/r Injurymentioning

confidence: 99%

Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury

Zheng

Chi

et al. 2022

Biomolecules

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Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction. Previous studies have shown that different types of cell death, including apoptosis, necrosis, and autophagy, can occur during I/R injury. Pyroptosis, which is characterized by cell membrane pore formation, pro-inflammatory cytokine release, and cell burst, and which differentiates itself from apoptosis and necroptosis, has been found to be closely related to I/R injury. Therefore, targeting the signaling pathways and key regulators of pyroptosis may be favorable for the treatment of I/R injury, which is far from adequate at present. This review summarizes the current status of pyroptosis and its connection to I/R in different organs, as well as potential treatment strategies targeting it to combat I/R injury.

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“… 162 Recently, exosomal miR-182-5p was found to reduce cell inflammation and pyroptosis by downregulating the expression of GASMD. 163 Moreover, exosomal miRNAs were also implicated in regulating macrophage activation and polarization. Transferred into macrophages from hypertrophic CMs, miR-155 promotes macrophage activation and secretion of inflammatory cytokines IL-6 and IL-8 via the MAPK pathway.…”

Section: Exosomal Micrornas In Ventricular Remodeling Following Myoca...mentioning

confidence: 99%

Exosomes and Exosomal Cargos: A Promising World for Ventricular Remodeling Following Myocardial Infarction

Fang¹,

Zhang²,

Chen³

et al. 2022

IJN

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Exosomes are a pluripotent group of extracellular nanovesicles secreted by all cells that mediate intercellular communications. The effective information within exosomes is primarily reflected in exosomal cargos, including proteins, lipids, DNAs, and non-coding RNAs (ncRNAs), the most intensively studied molecules. Cardiac resident cells (cardiomyocytes, fibroblasts, and endothelial cells) and foreign cells (infiltrated immune cells, cardiac progenitor cells, cardiosphere-derived cells, and mesenchymal stem cells) are involved in the progress of ventricular remodeling (VR) following myocardial infarction (MI) via transferring exosomes into target cells. Here, we summarize the pathological mechanisms of VR following MI, including cardiac myocyte hypertrophy, cardiac fibrosis, inflammation, pyroptosis, apoptosis, autophagy, angiogenesis, and metabolic disorders, and the roles of exosomal cargos in these processes, with a focus on proteins and ncRNAs. Continued research in this field reveals a novel diagnostic and therapeutic strategy for VR.

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Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice

Cited by 47 publications

References 64 publications

Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics

Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics

Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury

Exosomes and Exosomal Cargos: A Promising World for Ventricular Remodeling Following Myocardial Infarction

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