Mesenchymal stem cell-derived exosomes as a new drug carrier for the treatment of spinal cord injury: A review

Cheng, Lin-Fei; You, Chao-Qun; Peng, Cheng; Ren, Jia-Ji; Guo, Kai; Liu, Tie-Long

doi:10.1016/j.cjtee.2024.03.009

Cited by 5 publications

(1 citation statement)

References 135 publications

(210 reference statements)

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“…These functional extracellular vesicles, secreted by various cell types, offer a means of intercellular communication and hold significant therapeutic potential. Exosomes derived from various kinds of cells, including mesenchymal stem cells (MSCs), have been extensively studied for their reparative effects in SCI [103]. With studies showing MSC-derived exosomes attenuating apoptosis and inflammation, promoting functional recovery, and protecting the BSCB, the current direction in exosome research focuses on enhancing their therapeutic efficacy.…”

Section: Future Perspective and Challengesmentioning

confidence: 99%

Spinal Cord Injury Management Based on Microglia-Targeting Therapies

Schreiner,

Ciobanu

2024

JCM

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Spinal cord injury is a complicated medical condition both from the clinician’s point of view in terms of management and from the patient’s perspective in terms of unsatisfactory recovery. Depending on the severity, this disorder can be devastating despite the rapid and appropriate use of modern imaging techniques and convenient surgical spinal cord decompression and stabilization. In this context, there is a mandatory need for novel adjunctive therapeutic approaches to classical treatments to improve rehabilitation chances and clinical outcomes. This review offers a new and original perspective on therapies targeting the microglia, one of the most relevant immune cells implicated in spinal cord disorders. The first part of the manuscript reviews the anatomical and pathophysiological importance of the blood-spinal cord barrier components, including the role of microglia in post-acute neuroinflammation. Subsequently, the authors present the emerging therapies based on microglia modulation, such as cytokines modulators, stem cell, microRNA, and nanoparticle-based treatments that could positively impact spinal cord injury management. Finally, future perspectives and challenges are also highlighted based on the ongoing clinical trials related to medications targeting microglia.

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Section: Future Perspective and Challengesmentioning

confidence: 99%