Mesenchymal Stem Cell Injections Improve Symptoms of Knee Osteoarthritis

Koh, Yong‐Gon; Jo, Seung-Bae; Kwon, Ohchan; Suh, Dong-Suk; Lee, Seung-Woo; Park, Sungho; Choi, Yeonho

doi:10.1016/j.arthro.2012.11.017

Cited by 326 publications

(316 citation statements)

References 27 publications

Supporting

Mentioning

300

Contrasting

Unclassified

Order By: Relevance

“…3 To our knowledge this is the first clinical controlled trial with autologous BM-SC stimulated in vivo with a single intra-articular injection for the treatment of knee OA. Our study differs from other research developed in [24][25][26][27][28][29] In humans, other studies have been performed using stem cells from different collection sites such as adipose tissue [30][31][32][33] or peripheral blood through apheresis. 34,35 Some studies include case series and clinical trials with BM mesenchymal cells; some of them administered the cells by means of surgical intervention 13,[36][37][38] and others with intra-articular injection.…”

Section: Discussioncontrasting

confidence: 48%

The effect of intra‐articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

et al. 2017

View full text Add to dashboard Cite

Aim: Management of osteoarthritis (OA) is basically symptomatic. Recently, stem cells (SC) have been used in the search for an optimum treatment. We decided to conduct a controlled clinical trial to determine if a single intra-articular injection of in vivo stimulated bone marrow SC could lead to an improvement in pain management and quality of life in patients with knee OA.Method: This was a prospective, open-label, phase I/II clinical trial to assess the safety and efficacy of a single intra-articular injection of autologous stimulated bone marrow stem cells (BM-SC) in patients with knee OA. Individuals of both genders older than 30 years with confirmed diagnosis of OA who signed informed consent were included in two groups: SC group received in vivo BM stimulation with subcutaneous administration of granulocyte colony stimulating factor (G-CSF). SC were obtained by BM aspiration and administered in a single intra-articular injection. The control group received exclusively oral acetaminophen. Visual analogue scale and Western Ontario and McMaster Universities Osteoarthritis Index scores were performed at 1 week, 1 month and 6 months in both groups. This trial was registered in ClinialTrials.gov NCT01485198.Results: A total of 61 patients were included. Socio-demographic characteristics, OA grades and initial scores were similar in both groups. The BM-SC group showed significant improvement in knee pain and quality of life during the 6-month follow-up. Conclusion:The study demonstrates feasibility and supports efficacy of a completely ambulatory procedure in treatment of knee OA.

show abstract

Section: Discussioncontrasting

confidence: 48%

The effect of intra‐articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Four systematic reviews (35)(36)(37)(38) were also excluded. An assessment of the remaining 18 studies revealed that 10 used a single-arm prospective design (18)(19)(20)(39)(40)(41)(42)(43)(44)(45), four used quasi-experimental trials (46)(47)(48)(49) and four used RCT (50-53) (Table I). A total of 565 participants (226 males and 339 females) were included from the 18 studies.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…MSCs, which can be derived from blood, bone marrow, skeletal muscle, adipose, skin and synovial membrane (13), have the capacity to differentiate into osteocytes, adipocytes, chondrocytes, myoblasts, tenocytes (14,15), secrete bioactive molecules that stimulate angiogenesis and tissue repair, and reduce the response of T cells and inflammation (16,17). Previous clinical trials have reported that mild/moderate OA or advanced OA can be treated efficiently using autologous or allogenic MSCs through implantation, micro fracture or intra-articular injections (18)(19)(20). However, so far, no meta-analytic research has evaluated the efficacy and safety of MSCs in treating patients with KOA.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis

Cui

Wang

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. To assess the clinical efficacy and safety of mesenchymal stem cell (MSC) treatment for osteoarthritis of the knee (KOA), a systematic electronic literature search was performed on PubMed, EMBASE and Web of Science. Studies published in English from the earliest record to December 2014 were searched using the following keywords: Cartilage defect, cartilage repair, osteoarthritis, KOA, stem cells, MSCs, bone marrow concentrate (BMC), adipose-derived mesenchymal stem cells, synovial-derived mesenchymal stem cells and peripheral blood-derived mesenchymal stem cells. The effect sizes of selected studies were determined by extracting pain scores from the visual analog scale and functional changes from International Knee Documentation Committee and Lysholm and Western Ontario and McMaster Universities Osteoarthritis Index before and after MSCs or reference treatments at 3, 6, 12, and 24 months. The factors were analyzed and the outcomes were modified after comparing the MSC group pooled values with the pretreatment baseline or between different treatment arms. A systematic search identified 18 clinical trials on this topic, including 10 single-arm prospective studies, four quasi-experimental studies and four randomized controlled trials that used BMCs to treat 565 patients with KOA in total. MSC treatment in patients with KOA showed continual efficacy for 24 months compared with their pretreatment condition. Effectiveness of MSCs was improved at 12 and 24 months post-treatment, compared with at 3 and 6 months. No dose-responsive association in the MSCs numbers was demonstrated. However, patients with arthroscopic debridement, activation agent or lower degrees of Kellgren-Lawrence grade achieved improved outcomes. MSC application ameliorated the overall outcomes of patients with KOA, including pain relief and functional improvement from basal evaluations, particularly at 12 and 24 months after follow-up.

show abstract

“…The method is the simplest and easiest procedure for stem cell treatment of OA [18]. Koh Y G et al [60] concluded that the intra-articular injection of infrapatellar fat pad-derived MSCs is effective for alleviating the pain and improving knee function in patients with knee OA. Stem cells were prepared with platelet-rich plasma and injected directly into the knee with OA.…”

Section: Intra-articular Mscs Injectionmentioning

confidence: 99%

“…Stem cells were prepared with platelet-rich plasma and injected directly into the knee with OA. Clinical improvement was monitored pre-operatively and during follow up with the Western Ontario and McMaster Universities Osteoarthritis Index, the Lysholm score, and the visual analog scale (VAS) as well as magnetic resonance imaging (MRI) at the final follow up [60].…”

Section: Intra-articular Mscs Injectionmentioning

confidence: 99%

Osteoarthritis and Mesenchymal Stem Cell Therapy: An Overview

Purwanthi¹,

Marta²,

Adiwardhana³

2017

Recent Advances in Biology and Medicine

View full text Add to dashboard Cite

Osteoarthritis (OA) is the most common form of arthritis that affects cartilage joints and leads to disability. OA becomes the major public health problem, as it is the most leading cause of disability and morbidity worldwide. Treatment choices for OA can be classified into several categories such as non-pharmacologic, pharmacologic, surgical therapy, and cell-based therapy. There is no curative treatment for OA, while conventional treatments that are commonly used focus on alleviating the pain as the main symptom of the disease. Mesenchymal stem cells (MSCs) that can be found in several tissues of human body offer a new strategy for OA treatment owing to their ability to differentiate into chondrocytes. This article provides an overview about the basic concept of osteoarthritis as well as an insight about the MSCs therapy, including their basic characteristics, source, and transplantation strategies in the OA area.

show abstract

Mesenchymal Stem Cell Injections Improve Symptoms of Knee Osteoarthritis

Cited by 326 publications

References 27 publications

The effect of intra‐articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

The effect of intra‐articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis

Osteoarthritis and Mesenchymal Stem Cell Therapy: An Overview

Contact Info

Product

Resources

About