2022
DOI: 10.1111/ajt.17001
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Mesenchymal stem cells augment regulatory T cell function via CD80-mediated interactions and promote allograft survival

Abstract: Mesenchymal stem cells (MSCs) and regulatory T cells (Tregs) both have been shown to modulate the alloimmune response and promote transplant survival. Mounting evidence suggests that MSCs augment Treg function, but the mechanisms underlying this phenomenon have not been fully deciphered. Here, we identified that MSCs express substantial levels of CD80 and evaluated its immunoregulatory function using in vivo and in vitro experiments. Our in vitro culture assays demonstrated that MSCs induce expression of FoxP3… Show more

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Cited by 17 publications
(13 citation statements)
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“… 27 , 28 Recently, we and others have demonstrated that the administration of MSCs regulates adaptive immunity by suppressing APC activation and promoting regulatory T-cell function in a contact-dependent manner. 6 , 16 Here, we demonstrate that MSCs regulate adaptive immunity by directly suppressing effector T-cell function in the setting of allogeneic delayed-type hypersensitivity response.…”
Section: Discussionmentioning
confidence: 70%
See 1 more Smart Citation
“… 27 , 28 Recently, we and others have demonstrated that the administration of MSCs regulates adaptive immunity by suppressing APC activation and promoting regulatory T-cell function in a contact-dependent manner. 6 , 16 Here, we demonstrate that MSCs regulate adaptive immunity by directly suppressing effector T-cell function in the setting of allogeneic delayed-type hypersensitivity response.…”
Section: Discussionmentioning
confidence: 70%
“… 3-5 In a recent study, we have demonstrated that exogenous administration of MSCs suppresses immune-mediated graft rejection by directly interacting with T regulatory cells. 6 Despite the advancements in the understanding of the immunomodulatory functions of MSCs, whether MSCs directly regulate the activation and expansion of allogeneic T cells have yet to be investigated.…”
Section: Introductionmentioning
confidence: 99%
“…Previous studies have indicated that MSCs may regulate T-cell activation by expression of co-stimulatory molecules CD80, PD-L1 38 , and PD-L2 39 , yet little is known about changes in cell-surface proteins of IBD-derived MSCs after IFN-γ priming and whether their response differs from Ctrl. Thus, we investigated the expression levels of immunomodulatory proteins on intestinal MSCs by flow cytometry after IFN-γ priming.…”
Section: Resultsmentioning
confidence: 99%
“…Mesenchymal stromal cells (MSC) have both regenerative and immunomodulatory properties and are of interest as potential cellular therapy in transplantation because they may promote tolerance through interaction with various immune cell subsets, including regulatory T cells 15,16 . Recently, the Triton study demonstrated that recipients of a first, living‐donor kidney allograft who were treated with autologous MSCs, could be safely weaned from tacrolimus early after transplantation 17 .…”
Section: Introductionmentioning
confidence: 99%
“…Mesenchymal stromal cells (MSC) have both regenerative and immunomodulatory properties and are of interest as potential cellular therapy in transplantation because they may promote tolerance through interaction with various immune cell subsets, including regulatory T cells. 15,16 Recently, the Triton study demonstrated that recipients of a first, living-donor kidney allograft who were treated with autologous MSCs, could be safely weaned from tacrolimus early after transplantation. 17 In this sub-study, we analyzed dnDSA formation in kidney-transplant recipients treated with MSC therapy and subsequent tacrolimus withdrawal, and the potential association with the degree of HLA eplet mismatch between recipient and the kidney donor.…”
Section: Introductionmentioning
confidence: 99%