Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models

Shin, Jin Young; Park, Hyun Jung; Kim, Hana; Oh, Se Hee; Bae, Jung Hoon; Ha, Hee Jin; Lee, Phil Hyu

doi:10.4161/auto.26508

Cited by 224 publications

(186 citation statements)

References 56 publications

Supporting

Mentioning

176

Contrasting

Unclassified

Order By: Relevance

“…As suggested by previous study [20], approximately 1 × 10 6 cells suspended in 200 μl of normal saline were transplanted into each mouse through the tail vein. For those mice that received resveratrol directly, resveratrol was administered by oral gavage (200 mg/kg·per day) for 8 weeks.…”

Section: Methodsmentioning

confidence: 99%

Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer’s disease

Wang

Yang

et al. 2018

Behavioural Brain Research

View full text Add to dashboard Cite

Mesenchymal stem cell transplantation is a promising therapeutic approach for Alzheimer’s disease (AD). However, poor engraftment and limited survival rates are major obstacles for its clinical application. Resveratrol, an activator of silent information regulator 2, homolog 1 (SIRT1), regulates cell destiny and is beneficial for neurodegenerative disorders. The present study is designed to explore whether resveratrol regulates the fate of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and whether hUC-MSCs combined with resveratrol would be efficacious in the treatment of neurodegeneration in a mouse model of AD through SIRT1 signaling. Herein, we report that resveratrol facilitates hUC-MSCs engraftment in the hippocampus of AD mice and resveratrol enhances the therapeutic effects of hUC-MSCs in this model as demonstrated by improved learning and memory in the Morris water maze, enhanced neurogenesis and alleviated neural apoptosis in the hippocampus of the AD mice. Moreover, hUC-MSCs and resveratrol jointly regulate expression of hippocampal SIRT1, PCNA, p53, ac-p53, p21, and p16. These data strongly suggests that hUC-MSCs transplantation combined with resveratrol may be an effective therapy for AD.

show abstract

Section: Methodsmentioning

confidence: 99%

Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer’s disease

Wang

Yang

et al. 2018

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

“…Recently, Shin et al [84] investigated whether mesenchymal stem cells (MSCs) could enhance autophagy and therefore exert a neuroprotective effect through modulation of Aβ clearance in Aβ-treated neuronal cells. Administration of MSC to Aβ-treated animals upregulated BECN1/Beclin 1 expression and significantly increased autophagosome induction, maturation of late AVs, and fusion with lysosomes in addition to significantly reducing Aβ levels in the hippocampusin the Aβ-treated mice, concomitant with increased survival of hippocampal neurons.…”

Section: App Processing and Autophagic Dysfunctionmentioning

confidence: 99%

Autophagy in Alzheimer’s disease

Zare-Shahabadi

Masliah

Johnson

et al. 2015

Reviews in the Neurosciences

185

132

View full text Add to dashboard Cite

AbstractAutophagy is a vesicle and lysosome-mediated degradative pathway that is essential for protein homeostasis and cell health. In particular, compared to nonneuronal cells, neurons are dependent on high basal autophagy for survival. There is emerging agreement that defects in autophagy are likely to contribute to the neurodegenerative processes in numerous diseases, including Alzheimer’s disease (AD). Autophagy-lysosome defects occur early in the pathogenesis of AD and have been proposed to be a significant contributor to the disease process. Given the fact that autophagy deficits are likely major contributors to the etiology of AD, the focus of this review will be on recent studies that support a role for autophagy deficits in AD.

show abstract

“…(4) Inhibition of cell apoptosis and cell death MSCs can inhibit cell apoptosis and cell death caused by either Aβ or tau [34,37] , which are accompanied by memory improvement [73] .…”

Section: (3) Enhancing Endogenous Synaptogenesismentioning

confidence: 99%

Cell-based therapy in Alzheimer's disease: Current knowledge and perspective

Qiao

Huang²,

Chen

2016

Transl. Neurosci. Clin.

View full text Add to dashboard Cite

KEYWORDSAlzheimer's disease; cell therapy; stem cells; neurogenesis Alzheimer's disease (AD) is the most prevalent type of dementia, and its neuropathology is characterized by the deposition of insoluble β-amyloid (Aβ) peptides, intracellular neurofibrillary tangles, amyloid angiopathy, age-related brain atrophy, synaptic pathology, white matter rarefaction, granulovacuolar degeneration, neuron loss, and neuroinflammation. Although much is known about the neurobiology of AD, very few conventional therapies are available to arrest or slow the disease. There is an urgent need for novel therapeutic approaches for AD. AD subjects have significantly fewer viable precursor cells in the hippocampus compared with age-matched healthy control subjects. However, the viable precursor cells that remain in AD and age-matched healthy control brain specimens can be induced to differentiate. To facilitate or mimic the natural compensatory effect in AD, cell therapy, including endogenous and exogenous stem cells, has been considered in AD. In this review, we focus on the history and development of cell therapy in AD, and consider the role of cell therapy as a potential treatment for AD.Citation Qiao LY, Huang HY, Chen L. Cell-based therapy in Alzheimer's disease: Current knowledge and perspective. Transl. Neurosci. Clin. 2016, 2(1): 50-58.

show abstract

Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models

Abstract: (2014) Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models, Autophagy, 10:1, 32-44,

Cited by 224 publications

References 56 publications

Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer’s disease

Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer’s disease

Autophagy in Alzheimer’s disease

Cell-based therapy in Alzheimer's disease: Current knowledge and perspective

Contact Info

Product

Resources

About