Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin

Qin, Lei; Liu, Nian; Bao, Chaolemeng; Yang, Di; Ma, Gui-xing; Yi, Wei; Xiao, Guozhi; Cao, Hongrui

doi:10.1038/s41401-022-00952-0

Cited by 57 publications

(31 citation statements)

References 322 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is much evidence that transplanted MSCs not only prevent the death of specialized cells of the affected tissue [33], but also have the ability to interact with the resident stem cells of the affected tissue and attract them to the lesions [45]. The question of the interaction of transplanted MSCs with resident MSCs of cartilage tissue remains open, but given the potential importance of this interaction, it can be assumed that MSCs for transplantation should have significant paracrine potential and the ability to chemoattract.…”

Section: Results Discussionmentioning

confidence: 99%

Current problems and persprectives of the treatment of cartilage injuries using mesenchimal stem cells

Fishchenko¹,

Botsul²,

Shuvalova³

et al. 2022

Rep. of Vinnytsia Nation. Med. Univ.

View full text Add to dashboard Cite

Annotation. Since standard methods of treatment of cartilage trauma and inflammatory diseases lack effectiveness, at present one of the most promising strategies is mesenchymal stem cell transplantation. Despite the successes in this field, many issues, such as the selection of the tissue-source of mesenchymal stem cells (MSCs) and their optimization or modification in culture in order to achieve the maximum therapeutic effect, remains an actual task for both global and domestic scientists. The purpose of the study is to prepare a review of literature sources for the period 2004-2022 (in the vast majority on publications of the last five years) and to systematize new data on the biological characteristics of MSCs from various tissue sources, which are used in strategies for the treatment of cartilage lesions tissues, to analyze existing problems and further prospects, as well as potential ways of optimizing MSC cultivation methods to increase their regenerative potential. A study of 49 sources that met the inclusion criteria was carried out. A significant variety of strategies for the use of MSCs in animal models and in clinical practice was revealed. The main mechanisms ensuring the therapeutic effect of MSCs have been determined and can be used as criteria for optimizing cellular material. However, it was found that the question of the effectiveness of the use of differentiated MSCs, the selection of the tissue-source of MSCs, and the specifics of the use of MSCs from neonatal sources remains open. Thus, the analysis of literary sources revealed further promising ways to improve the therapeutic efficiency of MSC grafting in a wide range of cartilaginous lesions. There is a need to research the effects of MSCs from neonatal tissues, and especially the umbilical cord. This will become possible due to experimental research that will be carried out in the future.

show abstract

Section: Results Discussionmentioning

confidence: 99%

Current problems and persprectives of the treatment of cartilage injuries using mesenchimal stem cells

Fishchenko¹,

Botsul²,

Shuvalova³

et al. 2022

Rep. of Vinnytsia Nation. Med. Univ.

View full text Add to dashboard Cite

show abstract

“…It remains unclear whether the restriction of MSC differentiation observed in our study, caused by both types of oxidative stress, is a controlled omission of differentiation or a targeted preservation of the stem cell status. The investigation of further differentiation pathways of oxidatively stressed MSC, e.g., differentiation into myofibroblasts, which can be induced under pro-inflammatory conditions [ 59 ], could shed light on this open question.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress Response in Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells

Waheed

Hahn

Sridharan

et al. 2022

IJMS

View full text Add to dashboard Cite

Reactive oxygen species (ROS) can irreversibly damage biological molecules, a process known as oxidative stress. Elevated ROS levels are associated with immune cell activation. Sustained immune system activation can affect many different cells in the environment. One cell type that has been detected in almost all tissues of the body is mesenchymal stem/stromal cells (MSC). MSC possess proliferation and differentiation potential, thus facilitating regeneration processes. However, the regenerative capacity of MSC might be impaired by oxidative stress, and the effects of long-term oxidative stress on MSC functions are sparsely described. The examination of oxidative stress is often performed by exposure to H2O2. Since H2O2 is rapidly degraded, we additionally exposed the cell cultures to glucose oxidase (GOx), resulting in sustained exposure to H2O2. Using these model systems, we have focused on the effects of short- and long-term oxidative stress on viability, migration, differentiation, and signaling. All cellular functions examined were affected by the applied oxidative stress. The differences that occur between pulsed and sustained oxidative stress indicated higher oxidative stress in MSC upon direct H2O2 exposure, whereas the GOx-induced prolonged exposure to H2O2 seems to allow for better cellular adaptation. The mechanisms underlying these different responses are currently unknown.

show abstract

“…[20][21][22][23] Several authors have also pointed out that autologous or allogeneic MSCs seem to act in a completely different manner from resident MSCs. 5…”

Section: Discussionmentioning

confidence: 99%

“…Mesenchymal stem cells (MSCs) have been postulated by a number of authors to be the precursor cells of fibroblasts and myofibroblasts in keloids. 1,[4][5][6] They have been seen as a regenerative pool that ensures a steady supply of proliferative cells. Their role in keloid recurrence is however not known: whether there are any differences in MSC in keloids that recur and those that do not has not been documented.…”

Section: Introductionmentioning

confidence: 99%

Do Mesenchymal Stem Cells Influence Keloid Recurrence?

Nang'ole¹,

Anzala²,

Ogeng’o³

et al. 2022

SCCAA

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) have been postulated by a number of authors to be the precursor cells of fibroblasts and myofibroblasts in keloids. They have been seen as a regenerative pool that ensures a steady supply of cells. The objective of our study was to determine MSCs in keloids and normal skin as a determinant of keloid recurrence. Methods: This was a longitudinal prospective study in which patients with keloid excisions of their specimens analyzed for MSC. A control group of patients matched for age, sex, and body-mass index (BMI) with no history of keloids admitted for elective surgical procedures had their skin samples taken and also analyzed for MSCs. Data collected were analyzed and compared using Student's t, x 2 , and Fisher's exact t tests. Results: A total of 61 patients with keloids and a control group of 32 patients were recruited. The male:female ratio was 1:2 and mean age 29.5 and 29.7 years for keloids and controls, respectively. Patients with recurrent keloids had a mean density of 841.4 MSCs/g compared to 578 MSCs/g of tissue for those with no recurrence and 580 MSCs/g for patients with normal skin. Recurrent keloids had a significantly higher percentage of MSCs than those without. Conclusion: Keloids compared to normal skin had a higher percentage of MSCs, with recurrent keloids demonstrating an even higher count, a possible indicator that MSCs might correlate with severity of keloid disease and recurrence.

show abstract

Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin

Cited by 57 publications

References 322 publications

Current problems and persprectives of the treatment of cartilage injuries using mesenchimal stem cells

Current problems and persprectives of the treatment of cartilage injuries using mesenchimal stem cells

Oxidative Stress Response in Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells

Do Mesenchymal Stem Cells Influence Keloid Recurrence?

Contact Info

Product

Resources

About