2020
DOI: 10.3329/bjms.v19i4.46635
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Mesenchymal Stem Cells Induce Regulatory T-cell Population in Human SLE

Abstract: Background: The mechanisms underlying peripheral disorders during systemic lupus erythematosus (SLE) were found to be shared with tolerance disorders and mediated by T-regulator (T-reg) cells. Mesenchymal stem cells (MSCs) may inhibit T-cell subset differentiation and induce the T-reg cell phenotype. However, the capacity of MSCs to promote functional T-reg cells in SLE patients remains unclear. Objectives: This study aimed to analyze the capacity of MSCs to induce the production of functional CD4+ CD25+… Show more

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Cited by 13 publications
(15 citation statements)
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“…MSCs' capability to decrease the activation of the most proinflammatory-related Th cells has opened up a new understanding of SLE disease's. The MSCs capacity to suppress the proinflammatory condition in SLE depending on their responses to the type of immune cells, whether by inhibiting or modulating the immune cells [7], [8]. The one mechanisms of MSCs in controlling the inflammation is by suppressing the activated APC such as macrophage and DCs in releasing IL-12 to communicate with T-cell populations [10], [12].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…MSCs' capability to decrease the activation of the most proinflammatory-related Th cells has opened up a new understanding of SLE disease's. The MSCs capacity to suppress the proinflammatory condition in SLE depending on their responses to the type of immune cells, whether by inhibiting or modulating the immune cells [7], [8]. The one mechanisms of MSCs in controlling the inflammation is by suppressing the activated APC such as macrophage and DCs in releasing IL-12 to communicate with T-cell populations [10], [12].…”
Section: Discussionmentioning
confidence: 99%
“…The one reasoning use of MSCs to SLE studies is their ability to hamper an excessive inflammation Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia Open Access Macedonian Journal of Medical Sciences. 2020 Oct 29; 8(A):787-792. https://doi.org/10.3889/oamjms.2020.5120 eISSN: 1857-9655 Category: A -Basic Sciences Section: Immunology by enhancing the regulatory lymphocyte cells (Treg) modulation [7,8]. The functional Treg can release several anti-inflammatory cytokines that to inhibit the autoreactive T cells including T helper 1 (Th1) cell activation by downregulation of IL-12 [5], [9].…”
Section: Introductionmentioning
confidence: 99%
“…Another attractive potential of MSCs is their immunosuppressive ability in inhibiting the proliferation of T and B lymphocytes by releasing indoleamine 2,3-dioxygenase or nitric oxide, respectively, transforming growth factor β1 (TGF-β1), prostaglandin E2 (PGE2), and IL-10 [13]. Several studies reported that MSCs may suppress the autoreactive T lymphocytes of SLE by generating Treg functional, CD4+CD25+high Foxp3+ (iTreg) through direct contact, or releasing TGF-β1and PGE2 [14], [15].…”
Section: Introductionmentioning
confidence: 99%
“…MSCs express various surface markers such as CD105, CD90, and CD73, and do not express CD11b, CD14, CD19 or CD79a, CD45, CD34, or Human Leukocyte Antigen (HLA) class II [9] . In numerous studies, UC-MSCs have been shown to promote tissue regeneration by multilineage differentiation and immumodulatory capability, such as increasing IL-10 [10] and modulating regulatory T cell (T-reg) to control inflammatory cells [11,12] , despite under hypoxia tissue injuries [13] . The immunosuppressive properties of MSCs in controlling the excessive inflammation in injury sites can trigger the shift of inflammation phase to the proliferation leading to granulation tissue formation [14,15] .…”
Section: Introductionmentioning
confidence: 99%