Mesenchymal Stem Cells Promote Intestinal Mucosal Repair by Positively Regulating the Nrf2/Keap1/ARE Signaling Pathway in Acute Experimental Colitis

Liu, Peng; Xie, Xiaoran; Wu, Hao; Li, Huan; Chi, Jingshu; Liu, Xiaoming; Luo, Ju; Tang, Yu; Xu, Canxia

doi:10.1007/s10620-022-07722-2

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…This was in line with other findings using experimental colitis models that hUC-MSCs could modulate immunity and restore intestinal epithelial barrier integrity. 49 , 50 , 51 The immunomodulatory activity of hUC-MSCs is mainly provided by the paracrine pathway. 52 The major paracrine factors included prostaglandin E2 (PGE2), IDO, TGFβ1, TSG-6, and so on.…”

Section: Discussionmentioning

confidence: 99%

hUC-MSCs therapy for Crohn’s disease: efficacy in TNBS-induced colitis in rats and pilot clinical study

Sun,

Li,

Lin

et al. 2024

eBioMedicine

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Section: Discussionmentioning

confidence: 99%

hUC-MSCs therapy for Crohn’s disease: efficacy in TNBS-induced colitis in rats and pilot clinical study

Sun,

Li,

Lin

et al. 2024

eBioMedicine

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“…The ZO-1 protein is often used to assess the usual integrity of the intestine, and its expression or decreased levels can prevent the formation of tight junctions and cause intestinal inflammation. MSCs restore ZO-1 protein levels in DSS-induced colitis [112]. An experiment investigating the therapeutic mechanism of MSC-Exs in a rat model of intestinal ischemia-reperfusion (I/R) injury (IIRI) found that MSC-Exs increase Claudin-3, Claudin-2, and ZO-1 levels in Caco-2 cells and improve intestinal epithelial tight junctions.…”

Section: Repair Of the Intestinal Barriermentioning

confidence: 99%

“…Similarly, Yi-Jun Li found that miR-34a-5p also causes an increase in tight-junction-related proteins such as ZO-1, Occludin, Zonulin, and Claudin-3, and an analysis of the upstream signaling of miR-34a-5p revealed that METTL3/IGF2BP3-mediated m6A modification causes MSC-Exs to secrete miR-34a-5p levels, thereby upregulating the tight junction proteins [114]. Moreover, studies have shown that MSCs and MSC-Exs ameliorate the massive deposition of collagen in the colon submucosa of DSS mice [107,110,112].…”

Section: Repair Of the Intestinal Barriermentioning

confidence: 99%

Therapeutic Prospects of Mesenchymal Stem Cell and Their Derived Exosomes in the Regulation of the Gut Microbiota in Inflammatory Bowel Disease

Qiao,

Tang,

Liu

et al. 2024

Pharmaceuticals

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Mesenchymal stem cells (MSCs) have shown great potential in the treatment of several inflammatory diseases due to their immunomodulatory ability, which is mediated by exosomes secreted by MSCs (MSC-Exs). The incidence of inflammatory bowel disease (IBD) is increasing globally, but there is currently no long-term effective treatment. As an emerging therapy, MSC-Exs have proven to be effective in alleviating IBD experimentally, and the specific mechanism continues to be explored. The gut microbiota plays an important role in the occurrence and development of IBD, and MSCs and MSC-Exs can effectively regulate gut microbiota in animal models of IBD, but the mechanism involved and whether the outcome can relieve the characteristic dysbiosis necessary to alleviate IBD still needs to be studied. This review provides current evidence on the effective modulation of the gut microbiota by MSC-Exs, offering a basis for further research on the pathogenic mechanism of IBD and MSC-Ex treatments through the improvement of gut microbiota.

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“…Different studies described the beneficial effects of Nrf2/Keap1/ARE signaling modulation in some models of gut diseases. Particularly, it has been reported that mesenchymal stem cells (MSCs) promote intestinal healing by regulating Nrf2 [ 135 ]. Notably, other molecules also exert similar effects, such as epoxymicheliolide (EMCL) [ 136 ], carnosic acid [ 137 ], melianodiol [ 138 ], miconazole [ 139 ], sulphorafane (SFN), polyphenols and proanthocyanidin extracts [ 140 , 141 , 142 ].…”

Section: Other Considerations For Dmf-based Approaches In Intestinal ...mentioning

confidence: 99%

Dimethyl Fumarate and Intestine: From Main Suspect to Potential Ally against Gut Disorders

Manai,

Zanoletti,

Arfini

et al. 2023

IJMS

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Dimethyl fumarate (DMF) is a well-characterized molecule that exhibits immuno-modulatory, anti-inflammatory, and antioxidant properties and that is currently approved for the treatment of psoriasis and multiple sclerosis. Due to its Nrf2-dependent and independent mechanisms of action, DMF has a therapeutic potential much broader than expected. In this comprehensive review, we discuss the state-of-the-art and future perspectives regarding the potential repurposing of DMF in the context of chronic inflammatory diseases of the intestine, such as inflammatory bowel disorders (i.e., Crohn’s disease and ulcerative colitis) and celiac disease. DMF’s mechanisms of action, as well as an exhaustive analysis of the in vitro/in vivo evidence of its beneficial effects on the intestine and the gut microbiota, together with observational studies on multiple sclerosis patients, are here reported. Based on the collected evidence, we highlight the new potential applications of this molecule in the context of inflammatory and immune-mediated intestinal diseases.

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Mesenchymal Stem Cells Promote Intestinal Mucosal Repair by Positively Regulating the Nrf2/Keap1/ARE Signaling Pathway in Acute Experimental Colitis

Cited by 5 publications

References 33 publications

hUC-MSCs therapy for Crohn’s disease: efficacy in TNBS-induced colitis in rats and pilot clinical study

hUC-MSCs therapy for Crohn’s disease: efficacy in TNBS-induced colitis in rats and pilot clinical study

Therapeutic Prospects of Mesenchymal Stem Cell and Their Derived Exosomes in the Regulation of the Gut Microbiota in Inflammatory Bowel Disease

Dimethyl Fumarate and Intestine: From Main Suspect to Potential Ally against Gut Disorders

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