Mesenchymal Stromal Cell Therapy Reverses Detrusor Hypoactivity in a Chronic Kidney Patient

Abstract

Detrusor hypoactivity (DH) is characterized by low detrusor pressure or a short contraction associated with low urinary flow. This condition can progress to chronic renal failure (CRF) and result in the need for dialysis. The present case report demonstrates that a patient diagnosed with DH and CRF who received two transplants with 2 × 106 autologous mesenchymal stromal cells at an interval of 30 days recovered the contractile strength of the bladder and normalized his renal function. The patient had a score of 19 on the ICIQ-SF before cell therapy, and that score was reduced to 1 after transplantation. These results demonstrate that there was an improvement in his voiding function, urinary stream and urine volume as evaluated by urofluxometry. In addition, a urodynamic study carried out after treatment showed an increase in the maximum flow from 2 mL/s to 23 mL/s, the detrusor pressure in the maximum flow from 21 cm H2O to 46 cm H2O and a BCI that went from 31 to 161, characterizing good detrusor contraction. Thus, in the present case, the transplantation of autologous mesenchymal stromal cells proved to be a viable therapeutic option to allow the patient to recover the contractile strength of the bladder, and reversed the CRF.

Stem cell therapy for interstitial cystitis/bladder pain syndrome

“…These sources include adult and fetal tissues and human embryonic stem cells (hESCs). Although clinical trials with stem cell therapy have been reported in erectile dysfunction, 10 stress urinary incontinence, 11 and detrusor underactivity, 12 none have been conducted for IC/BPS in the field of urology.…”

Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives

“…This indicates a slight or significant improvement in UAB symptoms. Recently, Coelho et al reported on a 54-year-old male patient who underwent intravesical injections of autologous mesenchymal stromal cells (AMSCs) [156]. The patient demonstrated a significant reduction in PVR from 800 mL to 20 mL as well as marked improvements in the maximum flow rate from 2 mL/s to 23 mL/s, maximum detrusion pressure from 21 cmH 2 O to 46 cmH 2 O, and BCI from 31 to 161.…”