Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats

Abstract

Mesenchymal stromal cells (MSCs) have been extensively investigated as a potential antiinflammatory treatment in many inflammatory‐related diseases; however, it remains unclear whether MSCs could be used to treat acute allergic rhinitis. A rat model of allergic rhinitis was treated with MSCs. The effect of MSCs on the inflammation of allergic rhinitis was evaluated by sneezing, nose rubbing, the pathology of the nasal mucosa, and the expression of interleukin 4, tumour necrosis factor alpha, and immunoglobulin E in the serum of rats. Also, the population of MSCs isolated from umbilical cords of humans was evaluated to determine if they could inhibit the symptoms and inflammation of acute allergic rhinitis in a rat model. We observed that this population of cells inhibited sneezing, nose rubbing, and changes in the pathology of the nasal mucosa. Intriguingly, we observed that MSCs reduced the expression of interleukin 4, tumour necrosis factor alpha, and immunoglobulin E in the serum. Furthermore, MSCs reduced the expression of histamine and the recruitment of macrophages in the nasal mucosa of allergic rhinitis rats. We reasoned that the effect of MSCs on allergic rhinitis might be through its regulation of the secretion of related cytokines from macrophages during the process of acute allergic rhinitis. This work suggested that MSCs from the umbilical cords of humans could be used as a positive clinical therapy for the human disease.

Adipose Tissue-Derived Mesenchymal Stem Cell Modulates the Immune Response of Allergic Rhinitis in a Rat Model

“…There was significant ( p < 0.05) elevation in a T H 2-dependent immune response indicated by an increase in the serum levels of OVA-specific IgE, IgG1, IgG2a, PGE2 and histamine in the AR group when compared with the control group (Figure 3). These findings are in accordance with several previous studies [33,34], which revealed that re-exposure to the same antigen triggers degranulation of mast cells via IgE-mediated mechanism and finally leads to an increased release of inflammatory mediators in nasal mucosa, manifested by sneezing, itching, and watery discharge [33,35]. Interestingly, treatment with MSCs had a statistically significant ( p < 0.05) tendency to reduce the secretion of IgE, IgG1, and histamine, indicating that MSCs may downregulate T H 2 immune responses.…”

The effects of the transplantation of thymus-derived multipotent stromal cells on the immune system and survival of lethally irradiated mice

“…In addition, MSCs can suppress the pro-apoptotic processes by positive regulation of the anti-apoptotic proteins Bcl2 and p-Akt and reduction of the proapoptotic protein Bax expression [30]. Contact interaction of MSCs with different cells substantially supports their paracrine effects [31,32].…”

Metabolomics analysis of baicalin on ovalbumin-sensitized allergic rhinitis rats

“…All SD rats were randomly divided into three groups, with 10 rats in each group: a control group, model group and baicalin group. First, the model group and baicalin group were sensitized by OVA using a standard protocol as described in a previous study [12]. Briefly, the rats were sensitized by OVA via injection on days 1, 5 and 10; from days 15 to 21, the sensitized rats were intranasally challenged by daily droppings with OVA.…”