Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases

Shaw, Timothy D; Krasnodembskaya, Anna; Schroeder, Gunnar N.; Zumla, Alimuddin; Maeurer, Markus; O'Kane, Cecilia M

doi:10.1128/cmr.00064-21

Cited by 24 publications

(23 citation statements)

References 282 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combined disciplines of cell and gene therapy and tissue engineering, broadly known as regenerative medicine, have the potential to revolutionize the treatment of diseases ( De Luca et al, 2019 ). Mesenchymal stem cells (MSCs) have been the main subject of clinical trials for the functions of immunoregulation ( Tasso and Pennesi, 2009 ), differentiation potential ( Musina et al, 2006 ), pro-regeneration ( Jackson et al, 2010 ), and anti-infective property ( Shaw et al, 2021 ). Both hUCBMNCs and MSCs can be isolated from cord blood.…”

Section: Discussionmentioning

confidence: 99%

Human Umbilical Cord Blood Mononuclear Cells Ameliorate CCl4-Induced Acute Liver Injury in Mice via Inhibiting Inflammatory Responses and Upregulating Peripheral Interleukin-22

Zhang

Zhai

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Background: Human umbilical cord blood mononuclear cells (hUCBMNCs) show therapeutic effects on many inflammatory diseases. The deterioration of acute liver injury is attributed to excessive inflammatory responses triggered by damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). Whether hUCBMNCs treatment is a promising strategy for acute liver injury/failure needs to be investigated.Methods: Liver injury mice induced by PAMPs, DAMPs, or DAMPs plus PAMPs were developed. DAMPs included CCl4 (carbon tetrachloride), APAP (acetaminophen), and ConA (Concanavalin A). PAMPs included Klebsiella pneumoniae (K.P.) and Salmonella typhimurium (S. Typhimurium). DAMP plus PAMP-induced liver injury was developed by sequential CCl4 and K.P. administration. hUCBMNCs were injected intravenously.Results: hUCBMNCs significantly prolonged mice survival time in DAMP plus PAMP-induced liver failure but had no benefit in bacteria-infected mice. hUCBMNCs significantly alleviated hepatic necrosis post CCl4/ConA insult. In CCl4-induced acute liver injury, peripheral levels of interleukin (IL)-22 were upregulated and liver regeneration was enhanced after treating with hUCBMNCs at 48h. The levels of p62 and LC3B-II, autophagy markers, were also upregulated in the hUCBMNC-treated group.Conclusion: hUCBMNCs as a kind of cell therapeutic strategy could attenuate acute liver injury in mice, which is executed by enhancing autophagy and regeneration in the liver via inhibiting inflammatory responses and upregulating peripheral IL-22.

show abstract

Section: Discussionmentioning

confidence: 99%

Human Umbilical Cord Blood Mononuclear Cells Ameliorate CCl4-Induced Acute Liver Injury in Mice via Inhibiting Inflammatory Responses and Upregulating Peripheral Interleukin-22

Zhang

Zhai

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“… Schematic representation of potential direct antimicrobial activity of BM clot MSCs. Adapted from Shaw et al [ 21 ] by GIMP 2.10.32 software. …”

Section: Figurementioning

confidence: 99%

Vertebral Bone Marrow Clot towards the Routine Clinical Scenario in Spine Surgeries: What about the Antimicrobial Properties?

Contartese

Sartori

Tedesco

et al. 2023

IJMS

View full text Add to dashboard Cite

Exploring innovative techniques and treatments to improve spinal fusion procedures is a global challenge. Here, we provide a scientific opinion on the ability of a vertebral bone marrow (vBM) clot to provide a local combined delivery system not only of stem cells, signaling biomolecules and anti-inflammatory factors but also of molecules and proteins endowed with antimicrobial properties. This opinion is based on the evaluation of the intrinsic basic properties of the vBM, that contains mesenchymal stem cells (MSCs), and on the coagulation process that led to the conversion of fibrinogen into fibrin fibers that enmesh cells, plasma but above all platelets, to form the clot. We emphasize that vBM clot, being a powerful source of MSCs and platelets, would allow the release of antimicrobial proteins and molecules, mainly cathelicidin LL- 37, hepcidin, kinocidins and cationic host defense peptides, that are per se gifted with direct and/or indirect antimicrobial effects. We additionally highlight that further studies are needed to deepen this knowledge and to propose vBM clot as multifunctional bioscaffold able to target all the main key challenges for spinal fusion surgery.

show abstract

“…They continue to suffer from long-term functional disability and reduced quality of life due to permanent lung damage. These sequelae arise from excessive and aberrant host immune and inflammatory responses to M.tb resulting in extensive tissue destruction (Menzies NA et al, 2022;Allwood BW et al,2022;Frank DJ et al, 2019;Rao et al 2021;Maeurer M et al, 2021;Shaw et al, 2021). For more holistic treatment of TB a range of Host-Directed Therapies (HDTs) with various mechanisms of action to enhance immune responses or reduce excessive inflammation, are being considered for use as adjunct therapy in addition to anti-TB drug treatment regimens.…”

Section: Host-drected Therapies For Tuberculosis Managementmentioning

confidence: 99%

Blue Skies research is essential for ending the Tuberculosis pandemic and advancing a personalized medicine approach for holistic management of Respiratory Tract infections.

Ntoumi¹,

Petersen²,

Mwaba³

et al. 2022

International Journal of Infectious Diseases

Self Cite

View full text Add to dashboard Cite

Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases

Cited by 24 publications

References 282 publications

Human Umbilical Cord Blood Mononuclear Cells Ameliorate CCl4-Induced Acute Liver Injury in Mice via Inhibiting Inflammatory Responses and Upregulating Peripheral Interleukin-22

Human Umbilical Cord Blood Mononuclear Cells Ameliorate CCl4-Induced Acute Liver Injury in Mice via Inhibiting Inflammatory Responses and Upregulating Peripheral Interleukin-22

Vertebral Bone Marrow Clot towards the Routine Clinical Scenario in Spine Surgeries: What about the Antimicrobial Properties?

Blue Skies research is essential for ending the Tuberculosis pandemic and advancing a personalized medicine approach for holistic management of Respiratory Tract infections.

Contact Info

Product

Resources

About