Mesenchymal stromal cells as universal donor cells

Atoui, Rony; Chiu, Ray Chu‐Jeng

doi:10.1517/14712598.2012.711307

Cited by 13 publications

(13 citation statements)

References 20 publications

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“…Rodent and human MSCs are advantageous owing to their immunomodulatory characteristics in both in vitro and in vivo transplant models, allowing them to act as a universal reserve of donor cells (Atoui & Chiu, 2012). MSCs’ unique immunotolerant phenotype is due to their special distribution of surface markers that allows them to escape detection from immune cells.…”

Section: Advantages Of Mscs Over Other Stem Cell Types In Clinical Apmentioning

confidence: 99%

Usage of Human Mesenchymal Stem Cells in Cell-based Therapy: Advantages and Disadvantages

2017

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The use of human mesenchymal stem cells (hMSCs) in cell-based therapy has attracted extensive interest in the field of regenerative medicine, and it shows applications to numerous incurable diseases. hMSCs show several superior properties for therapeutic use compared to other types of stem cells. Different cell types are discussed in terms of their advantages and disadvantages, with focus on the characteristics of hMSCs. hMSCs can proliferate readily and produce differentiated cells that can substitute for the targeted affected tissue. To maximize the therapeutic effects of hMSCs, a substantial number of these cells are essential, requiring extensive ex vivo cell expansion. However, hMSCs have a limited lifespan in an in vitro culture condition. The senescence of hMSCs is a double-edged sword from the viewpoint of clinical applications. Although their limited cell proliferation potency protects them from malignant transformation after transplantation, senescence can alter various cell functions including proliferation, differentiation, and migration, that are essential for their therapeutic efficacy. Numerous trials to overcome the limited lifespan of mesenchymal stem cells are discussed.

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Section: Advantages Of Mscs Over Other Stem Cell Types In Clinical Apmentioning

confidence: 99%

Usage of Human Mesenchymal Stem Cells in Cell-based Therapy: Advantages and Disadvantages

2017

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“…Several factors may have contributed to this success. We used MSCs from the bone marrow in an early passage (passage #4) and the cells are essentially non-immunogenic343536. A recent study used cells after 16 passages and failed to demonstrate any analgesic or anti-inflammatory effects11.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal Stem Cells Reversed Morphine Tolerance and Opioid-induced Hyperalgesia

Hua

Liu

Shen

et al. 2016

Sci Rep

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More than 240 million opioid prescriptions are dispensed annually to treat pain in the US. The use of opioids is commonly associated with opioid tolerance (OT) and opioid-induced hyperalgesia (OIH), which limit efficacy and compromise safety. The dearth of effective way to prevent or treat OT and OIH is a major medical challenge. We hypothesized that mesenchymal stem cells (MSCs) attenuate OT and OIH in rats and mice based on the understanding that MSCs possess remarkable anti-inflammatory properties and that both OT and chronic pain are associated with neuroinflammation in the spinal cord. We found that the development of OT and OIH was effectively prevented by either intravenous or intrathecal MSC transplantation (MSC-TP), which was performed before morphine treatment. Remarkably, established OT and OIH were significantly reversed by either intravenous or intrathecal MSCs when cells were transplanted after repeated morphine injections. The animals did not show any abnormality in vital organs or functions. Immunohistochemistry revealed that the treatments significantly reduced activation level of microglia and astrocytes in the spinal cord. We have thus demonstrated that MSC-TP promises to be a potentially safe and effective way to prevent and reverse two of the major problems of opioid therapy.

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“…MSCs are advantageous due to their immunomodulatory characteristics, which allow them to act as a universal reserve of donor cells (Fig. 1 ) [ 24 ]. These cells have a unique distribution of surface markers that allows them to escape detection from immune cells.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic use of stem cells for cardiovascular disease

Faiella

Atoui

2016

Clinical & Translational Med

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Stem cell treatments are a desirable therapeutic option to regenerate myocardium and improve cardiac function after myocardial infarction. Several different types of cells have been explored, each with their own benefits and limitations. Induced pluripotent stem cells possess an embryonic-like state and therefore have a high proliferative capacity, but they also pose a risk of teratoma formation. Mesenchymal stem cells have been investigated from both bone marrow and adipose tissue. Their immunomodulatory characteristics may permit the use of allogeneic cells as universal donor cells in the future. Lastly, studies have consistently shown that cardiac stem cells are better able to express markers of cardiogenesis compared to other cell types, as well improve cardiac function. The ideal source of stem cells depends on multiple factors such as the ease of extraction/isolation, effectiveness of engraftment, ability to differentiate into cardiac lineages and effect on cardiac function. Although multiple studies highlight the benefits and limitations of each cell type and reinforce the successful potential use of these cells to regenerate damaged myocardium, more studies are needed to directly compare cells from various sources. It is interesting to note that research using stem cell therapies is also expanding to treat other cardiovascular diseases including non-ischemic cardiomyopathies.

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Mesenchymal stromal cells as universal donor cells

Cited by 13 publications

References 20 publications

Usage of Human Mesenchymal Stem Cells in Cell-based Therapy: Advantages and Disadvantages

Usage of Human Mesenchymal Stem Cells in Cell-based Therapy: Advantages and Disadvantages

Mesenchymal Stem Cells Reversed Morphine Tolerance and Opioid-induced Hyperalgesia

Therapeutic use of stem cells for cardiovascular disease

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