Mesenchymal Stromal Cells for Wound Healing Therapy: From Expectations to Reality

Rosca, Ana-Maria; Tutuianu, Raluca; Ghetu, Daniela Madalina; Titorencu, Irina

doi:10.1007/978-981-99-0846-2_53-1

Cited by 1 publication

(2 citation statements)

References 137 publications

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“…On the other hand, chronic wounds impose a significant burden on global medical resources due to long‐term medical needs and high recurrence rates. 1 , 2 , 3 , 4 , 5 , 6 This problem of accelerating skin regeneration and restore the function of injured skin in essence demanded effective method to obtain a solution. 3 When the skin is injured, the wound healing process is initiated immediately and consists of four overlappings and spliced stages that occur at specific moments in the order of wound progress and continue with a certain intensity for a specific duration: (i) Haemostasis ‐ occurs immediately (ii) Inflammation ‐ begins immediately after injury and persists for 4–6 days, accompanied by massive production and release of pro‐angiogenic, cytokine, inflammatory and fibrotic factors.…”

Section: Introductionmentioning

confidence: 99%

“…(iv) ECM (Extracellular matrix) remodelling‐The ECM as well as granulation tissue are remodelled through reorganisation, degradation and resynthesis: Collagen III is replaced by Collagen I, forming collagen‐rich scar tissue. 2 , 4 , 7 , 8 Exosome of stem cell is embodied to assist in various stages of wound healing: promote new blood vessels, accelerate cell migration and proliferation, and even administer scarring. 9 Human adipose‐derived stem cells (ADSCs) are an efficient and high‐quality source of stem cells because of their convenience, wide availability, multi‐directional differentiation potential, self‐renewal potential, low immunogenicity, and high proliferation rate.…”

Section: Introductionmentioning

confidence: 99%

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Exosome derived from human adipose‐derived stem cell improve wound healing quality: A systematic review and meta‐analysis of preclinical animal studies

Tian

Meijia

Chen

et al. 2023

International Wound Journal

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Excellent capability of exosome derived from human adipose-derived stem cell (ADSC) manifested in improving the quality of wound healing with SMD (STD Mean Difference). However, it is still in the preclinical stage and its efficacy remains uncertain. Emphasised the need for a systematic review of preclinical studies to the validity of it in ameliorate wound healing quality which accelerate the clinical application translation. We performed a systematic literature review to identify all published controlled and intervention studies comparing exosome derived from human ADSC with placebo in animal models of wound closure during wound healing. PubMed, Embase and Cochrane were employed. Risk of bias assessed by the SYRCLE tool aimed at preclinical animal studies. Administration of exosome derived from human ADSC extremely improved wound closure compared with controls, which is primary outcome (SMD 1.423, 95% confidence interval (CI) 1.137-1.709 P < .001), the same effect as ADSC. The therapeutic effect is further enhanced by modified ADSC-EV. Other outcomes: density and the number of blood vessels: (SMD 1.593 95% CI 1.007-2.179 P < .001)； Fibrosis-related protein expression was highly expressed in the early term of wound healing, decreased in shaping period, which automatically regulates wound collagen deposition. Scar size, number of fibroblast and epithelial cell migration and proliferation expressed were ranked as follows: modified adipose stem cell exosomes > adipose stem cell exosomes > controls. Exosome derived from human ADSC, especially after enrichment for specific non-coding RNA, is a promising approach to improve healing efficiency.

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