Mesenchymal stromal/stem cells: historical perspective and ongoing challenges

Rossi, Maria Isabel D.; Bonfim, Danielle Cabral

doi:10.29374/2527-2179.bjvm112020

Cited by 2 publications

(2 citation statements)

References 128 publications

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“…Guimarães-Camboa and colleagues showed that pericytes and vascular smooth muscle cells, although multipotent in vitro, do not behave as MSCs in vivo [94]. These findings contrast with previous studies that also used lineage tracing assays and give rise to an ongoing debate regarding the progenitor hierarchy between MSCs and pericytes [94,108]. Both MSCs and pericytes take an active role in the formation of the PMN.…”

Section: Mscsmentioning

confidence: 86%

Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

et al. 2021

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Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future metastatic sites. Accumulation studies have revealed that tumour metastasis is not a disorderly spontaneous incident but the climax of a series of sequential and dynamic events including the development of a pre-metastatic niche (PMN) suitable for a subpopulation of tumour cells to colonize and develop into metastases. A deep understanding of the formation, characteristics and function of the PMN is required for developing new therapeutic strategies to treat tumour patients. It is rapidly becoming evident that therapies targeting PMN may be successful in averting tumour metastasis at an early stage. This review highlights the key components and main characteristics of the PMN and describes potential therapeutic strategies, providing a promising foundation for future studies.

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Section: Mscsmentioning

confidence: 86%

Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

et al. 2021

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“…In addition to the ability to differentiate, these cells are of great importance in regenerative medicine owing to their ability to mediate the immune response in injured tissues, e.g., immunomodulation for tissue regeneration (Miao et al, 2006). However, their characterization and clinical use remains challenging (Rossi & Bonfim, 2020).…”

Section: Ys-derived Mesenchymal Stem Cellsmentioning

confidence: 99%

Mammalian yolk sac - an alternative source of stem cells

Pinto

Pereira²,

Motta³

et al. 2021

Braz. J. Vet. Med.

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Fetal tissue-derived stem cells have been the subject of several studies. Among them, the yolk sac (YS) nourishes the embryo, synthesizes proteins and vitamins, and is the first hematopoietic site of the embryo. Stem cells derived from the YS can benefit several animal species as therapies aimed at tissue regeneration and immunological diseases. This review aims to describe the development, function, and possible dysfunctions of YS in different species, and consolidate the findings presented in the literature on the isolation, culture, and application of YS-derived stem cells from different mammals in regenerative medicine. Hematopoietic and mesenchymal stem cells have been previously investigated in the YS of different mammals; however, the culture media and isolation protocols differ between species. To date, no studies have been conducted using stem cells derived from the YS for cell therapy. Nevertheless, several domestic mammals have shown cellular markers characteristic of mesenchymal stem cells derived from the YS.

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Mesenchymal stromal/stem cells: historical perspective and ongoing challenges

Cited by 2 publications

References 128 publications

Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

Mammalian yolk sac - an alternative source of stem cells

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