Mesenchymal tumors of the uterus:III. A clinical and pathologic study of 31 carcinosarcomas

Norris, Henry J.; Taylor, Herbert B.

doi:10.1002/1097-0142(196610)19:10<1459::aid-cncr2820191019>3.0.co;2-a

Cited by 170 publications

(37 citation statements)

References 6 publications

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“…It has been previously reported that 70-90% of tumor-related deaths occurred within 18 months after diagnosis (2,12). However, a recent study reported that the prognosis of uterine carcinosacomas had improved, with an overall median survival of 39 months (13).…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of the uterus: A case report

Adachi

Nonogaki

Minamiguchi

et al. 2016

Molecular and Clinical Oncology

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Abstract. Carcinosarcoma is a rare malignant tumor of the uterus with a poor prognosis. We herein present a case of uterine carcinosarcoma in a 67-year-old woman suffering from pervaginal bleeding for 3 months, with progressive anemia. Upon biopsy of the endometrium, the tumor was diagnosed as endometrioid adenocarcinoma. Total hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node dissection were performed. The histological examination revealed that the tumor consisted of serous adenocarcinoma and sarcoma of homologous components. After the operation, chemotherapy with paclitaxel and carboplatin was administered. At approximately 3 years postoperatively, the patient remains alive and recurrence-free.

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Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of the uterus: A case report

Adachi

Nonogaki

Minamiguchi

et al. 2016

Molecular and Clinical Oncology

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“…The first classification of ESSs proposed by Norris et al 42 in 1966 divided them into low-and high-grade solely on the basis of mitotic activity with the cutoff of 10 mitoses per high-power field (HPF) ( Table 6). Significant clinical difference was observed between low-and high-grade ESS and therefore in the 2002 WHO classification, 43 both were combined into 1 category of low-grade ESS regardless of mitotic count (Table 6).…”

Section: Historical Perspective and Evolving Conceptsmentioning

confidence: 99%

Recent Developments in Surgical Pathology of the Uterine Corpus

Hanley

Birdsong

Mošunjac

2017

Archives of Pathology &Amp; Laboratory Medicine

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There have been several updates recently on the classification of uterine tumors. Endometrial carcinomas have traditionally been divided into 2 types, but some are difficult to classify and do not fit readily into either of the currently recognized categories. The Cancer Genome Atlas Research Network has recently defined 4 new categories of endometrial cancer on the basis of mutational spectra, copy number alteration, and microsatellite instability, which might provide independent prognostic information beyond established risk factors. The Society of Gynecologic Oncology, moreover, now recommends systematic screening of every patient with endometrial cancer for Lynch syndrome. The new definition of high-grade endometrial stromal sarcoma disregards the number of mitotic figures as a primary diagnostic criterion and instead specifies moderate atypia still resembling stromal origin but lacking the pleomorphism of undifferentiated uterine sarcoma; these tumors also harbor a JAZF1-SUZ12 gene rearrangement. Mitotic count, atypia, and coagulative necrosis are the main histologic criteria that define leiomyosarcoma. Determining the type of necrosis can be very challenging in patients receiving various treatment modalities for symptomatic fibroids before myomectomy, since key histologic features of ischemic-type necrosis are often absent. Ancillary stains including p16, p53, MIB-1, trichrome, and reticulin may be helpful in tumors harboring necrosis that is difficult to classify. Minimally invasive gynecologic surgeries have introduced histologic artifacts that complicate the diagnosis. It is essential to recognize these as procedure-related artifacts to avoid upstaging tumors and triggering unnecessary adjuvant treatment.

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“…Tanı anında uterus dışına yayımın yaygınlığı nedeniyle sürvileri oldukça kötüdür (12). Karsinomlara benzer şekilde karsinosarkomlar da pelvik ve paraaortik lenf nodlarına, pelvik yumuşak dokulara, vajen, peritoneal yüzeylere ve akciğere metastaz yapabilmektedir (13)(14)(15). Metastazların histolojik görünümleri değişken olmakla birlikte, lenfatik ve vasküler boşluklarda pür karsinom alanları, metastatik lezyonlarda daha sıklıkla karsinom alanları ve nadiren hem karsinom hem sarkom alanları izlenmektedir.…”

Section: Discussionunclassified

Uteri̇n Karsi̇nosarkomlar: 18 Olguda Hi̇stopatoloji̇k Gözden Geçi̇rme

et al. 2015

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Objective: Uterine carcinosarcomas are relatively rare tumors with poor prognosis. These tumors were considered as a subset of uterine sarcomas; however currently they are classified within the carcinoma group. Recent studies have revealed that these tumors behave according to the characteristics of the epithelial component. The aim of the study was to discuss the histopathological characteristics of these quite aggressive tumors, which were diagnosed in our clinic, in the light of the literature. Materials and Methods:We performed a retrospective analysis of 18 patients with uterine sarcoma, who were operated at our oncology department between 2004 and 2014. Cases with a pathology result of either carcinosarcoma or malignant mixed Müllerian tumor were included in the study pathologically. Tumor size, presence of myometrial invasion and pelvic lymph node metastases were reviewed. Demographic data were recorded. Staging was performed according to FIGO (1988) protocol.Results: 18 patients were diagnosed with carcinosarcoma. 95% of the patients were in postmenopausal period. The mean age was 64.6 (range 47-85). 13 patients underwent comprehensive surgical staging (total hysterectomy + bilateral salpingo-oophorectomy + pelvic para-aortic lymphadenectomy + omentectomy + appendectomy). 5 patients with advanced stage disease underwent suboptimal debulking. 7 patients were stage I and 11 patients were stage II-IV. Myometriyal invasion was present in 17 patients and for 9 of these patients the invasion was observed in more than ½ of the myometrium. Lymphovascular invasion was observed in 11 patients. Conclusion: Uterine carcinosarcomas are extremely aggressive neoplasms. Although they used to be categorized under the group of sarcoma, recent studies have shown that uterine carcinosarcomas are high-grade endometrial carcinomas, which include sarcomatous metaplasia. First-line treatment for uterine carcinosarcomas is surgery. Adjuvant chemotherapy and radiation therapy combinations are used as complementary therapies.

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Mesenchymal tumors of the uterus:III. A clinical and pathologic study of 31 carcinosarcomas

Cited by 170 publications

References 6 publications

Carcinosarcoma of the uterus: A case report

Carcinosarcoma of the uterus: A case report

Recent Developments in Surgical Pathology of the Uterine Corpus

Uteri̇n Karsi̇nosarkomlar: 18 Olguda Hi̇stopatoloji̇k Gözden Geçi̇rme

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