Mesenteric panniculitis: Still an ambiguous condition

Badet, N.; Sailley, N.; Briquez, ClÃ©ment; Paquette, Brice; Vuitton, Lucine; Delabrousse, Éric

doi:10.1016/j.diii.2014.12.002

Cited by 45 publications

(54 citation statements)

References 34 publications

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“…This was mostly because accrual was retrospective and relied upon identifying patients via a keyword search of the radiology information system. This approach will miss patients if the precise term does not appear in the report or those in whom the condition is not reported [6, 8, 10–12, 16, 19]. One study only recruited patients with a histological diagnosis, thus biasing accrual towards severe cases [15], whereas another recruited only patients having PET-CT, inducing bias towards patients with malignancy [18].…”

Section: Resultsmentioning

confidence: 99%

Mesenteric panniculitis: systematic review of cross-sectional imaging findings and risk of subsequent malignancy

2016

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ObjectivesSystematic review to determine any association between imaging features of idiopathic mesenteric panniculitis (MP) and subsequent malignancy.MethodsTwo researchers searched primary literature independently for imaging studies of MP. They extracted data focusing on methodology for unbiased patient accrual and capability to determine a link between MP and subsequent malignancy. They noted imaging features of MP. Data were accrued and meta-analysis intended.ResultsFourteen of 675 articles were eligible; 1,226 patients. Only three (21 %) accrued patients prospectively. Twelve (86 %) studies described CT features. Follow-up varied widely; 1 month to 8 years. Prevalence of MP was influenced by accrual: 0.2 % for keyword search versus 1.7 % for consecutive series. Accrual bias affected nine (64 %) studies. 458 (38 %) of 1,209 patients had malignancy at accrual but varied widely (8–89 %), preventing meta-analysis. Sixty (6.4 %) of 933 patients developed new malignancy subsequently, also varying widely (0–11 %). Of just four studies that determined the proportion of unselected, consecutive patients with MP developing subsequent malignancy, three were retrospective and the fourth excluded patients with lymphadenopathy, likely excluding patients with MP.ConclusionStudies were heterogeneous, with biased accrual. No available study can determine an association between MP and subsequent malignancy with certainty.Key Points• Our systematic review of mesenteric panniculitis found that imaging studies were biased.• Spectrum and recruitment bias was largely due to retrospective study designs.• No study could confirm a certain link between mesenteric panniculitis and subsequent malignancy.• Excessive methodological heterogeneity precluded meaningful meta-analysis.• High-quality research linking mesenteric panniculitis imaging features and subsequent malignancy is needed.

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Section: Resultsmentioning

confidence: 99%

Mesenteric panniculitis: systematic review of cross-sectional imaging findings and risk of subsequent malignancy

2016

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“…The differences could be due to the methodology of this study, i.e., retrospective or prospective. Some of the retrospective studies used the keywords "mesenteric panniculitis" or "panniculitis" or "sclerosing mesenteritis" for screening of the CT reports [2,6], while others reanalyzed all CT scans for the presence of MP [5,7]. Because the patients were selected based on radiologic reports in the current study, we might have had a lower prevalence of MP in the study population.…”

Section: Discussionmentioning

confidence: 99%

“…When inflammation and fat necrosis predominate over fibrosis, the condition is known as MP. Conversely, when fibrosis and retraction predominate, it is called sclerosing mesenteritis [1][2][3]. The gold standard for the diagnosis of MP is to demonstrate inflammatory and fibrotic changes in the mesentery histopathologically [3].…”

Section: Introductionmentioning

confidence: 99%

An Overlooked Potentially Treatable Disorder: Idiopathic Mesenteric Panniculitis

Şahin¹,

Artaş

Eroğlu

et al. 2017

Med Princ Pract

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Objective: The aim of this study was to determine the prevalence of mesenteric panniculitis (MP) and to describe its clinical characteristics, therapy, and outcome. Subjects and Methods: This retrospective study was carried out among patients with MP based on computed tomography (CT) scans from January 2012 to December 2015. The CT images were reanalyzed by study radiologists to confirm the previous MP diagnosis. Patients were divided into 2 groups, i.e., idiopathicandsecondary, based on the presence or absence of associated predisposing factors such as trauma, malignancy, autoimmune disorders, ischemia, or previous abdominal surgery. The clinical characteristics of the 2 groups, as well as treatments, were assessed. Results: Among the 19,869 CT scans, 36 patients (0.18%) with MP were identified (i.e., 19 [53%] females and 17 [47%] males). The median age was 54 years (range 26 - 76). Twenty-four patients (67%) were categorized into the idiopathic group. Malignancy was the predisposing factor in 8 (22%) of those patients. Furthermore, abdominal pain was the cardinal symptom observed in 22 patients (92%) in the idiopathic group. In the idiopathic group, 15 patients (63%) were treated with antibiotics and 16 (67%) were treated with nonsteroidal anti-inflammatory drugs (NSAID). One unresponsive patient was treated with colchicine. Symptomatic relief was achieved in all of the treated patients. Conclusion: In thisstudy, a symptomatic idiopathic subgroup of patients with MP did not have any associated disorder. The response to treatment with antibiotics and NSAID was effective in most of the patients. Based on these findings, anti-inflammatory treatments beyond NSAID and surgery should be reserved for patients who are unresponsive to antibiotics and NSAID.

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“…[1][2][3][4] The etiology remains unknown and hypothesized to be associated with previous abdominal surgery, abdominal trauma, autoimmune disease, drugs, cancer, ischemia, and infection. [5][6][7] The prevalence is 0.16-7.8%. Sclerosing mesenteritis is also reported in 0.6% of over than 7,000 patients undergoing abdominal computed tomography (CT) scan for other indications.…”

Section: Introductionmentioning

confidence: 99%

“…The hypothesis that supports SM as a paraneoplastic syndrome is still controversial. 7 This is a case of a male patient with the diagnosis of SM and poorly-differentiated caecal adenocarcinoma. The importance of SM diagnostic findings and relationship of SM with caecal adenocarcinoma will be highlighted.…”

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confidence: 99%

Diagnostic Findings of Sclerosing Mesenteritis and the Disease Correlations with Caecal Adenocarcinoma

Pribadi¹,

Abdullah²,

Iskandar³

et al. 2020

InaJGHE

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Mesenteric panniculitis: Still an ambiguous condition

Cited by 45 publications

References 34 publications

Mesenteric panniculitis: systematic review of cross-sectional imaging findings and risk of subsequent malignancy

Mesenteric panniculitis: systematic review of cross-sectional imaging findings and risk of subsequent malignancy

An Overlooked Potentially Treatable Disorder: Idiopathic Mesenteric Panniculitis

Diagnostic Findings of Sclerosing Mesenteritis and the Disease Correlations with Caecal Adenocarcinoma

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