Mesh deformation: A mechanism underlying polypropylene prolapse mesh complications in vivo

Knight, Katrina; King, Gabrielle E.; Palcsey, Stacy; Suda, Amanda; Liang, Rui; Moalli, Pamela

doi:10.1016/j.actbio.2022.05.051

Cited by 17 publications

(12 citation statements)

References 51 publications

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“…When implanted, it is of utmost importance that the scaffold mimics both the physiological and local anatomical conditions and, at the same time, it should be robust enough to maintain the structural integrity under the physical stress generated in the body. − Extensive cell culture studies were carried out on various polymeric electrospun scaffolds by various groups in the past. However, the majority of those studies were limited to merely demonstrating the cell attachment and growth only on delicate, plain sheet-like cell-impermeable 2D meshes spun by conventional multijet RJ electrospinning. , These major drawbacks forbade the electrospinning technique from reaching the next step toward achieving the scaffolds for clinical use for almost two decades.…”

Section: Resultsmentioning

confidence: 99%

Self-Searching Writing of Human-Organ-Scale Three-Dimensional Topographic Scaffolds with Shape Memory by Silkworm-like Electrospun Autopilot Jet

Navaneethan

Chou

2022

ACS Appl. Mater. Interfaces

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Bioengineered scaffolds satisfying both the physiological and anatomical considerations could potentially repair partially damaged tissues to whole organs. Although three-dimensional (3D) printing has become a popular approach in making 3D topographic scaffolds, electrospinning stands out from all other techniques for fabricating extracellular matrix mimicking fibrous scaffolds. However, its complex charge-influenced jet–field interactions and the associated random motion were hardly overcome for almost a century, thus preventing it from being a viable technique for 3D topographic scaffold construction. Herein, we constructed, for the first time, geometrically challenging 3D fibrous scaffolds using biodegradable poly(ε-caprolactone), mimicking human-organ-scale face, female breast, nipple, and vascular graft, with exceptional shape memory and free-standing features by a novel field self-searching process of autopilot polymer jet, essentially resembling the silkworm-like cocoon spinning. With a simple electrospinning setup and innovative writing strategies supported by simulation, we successfully overcame the intricate jet–field interactions while preserving high-fidelity template topographies, via excellent target recognition, with pattern features ranging from 100’s μm to 10’s cm. A 3D cell culture study ensured the anatomical compatibility of the so-made 3D scaffolds. Our approach brings the century-old electrospinning to the new list of viable 3D scaffold constructing techniques, which goes beyond applications in tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Self-Searching Writing of Human-Organ-Scale Three-Dimensional Topographic Scaffolds with Shape Memory by Silkworm-like Electrospun Autopilot Jet

Navaneethan

Chou

2022

ACS Appl. Mater. Interfaces

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“…The development of suitable animal models is key for the advancement of basic science research as it relates to mesh complication pathogenesis. Recently, Knight et al reproduced the mesh complication of exposure by implanting deformed mesh (pores collapsed and wrinkled) onto the vagina of nonhuman primates [94]. Specifically, mesh deformation led to two differing responses: tissue degradation (likely mechanism of mesh exposure) and myofibroblast proliferation (likely mechanism of pain).…”

Section: Advances In Science and Technology To Meet Challengesmentioning

confidence: 99%

Roadmap on biomaterials for women’s health

et al. 2022

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The application of engineering tools and techniques to studying women’s health, including biomaterials-based approaches, is a research field experiencing robust growth. Biomaterials are natural or synthetic materials used to repair or replace damaged tissues or organs or replicate an organ’s physiological function. However, in addition to in vivo applications, there has been substantial recent interest in biomaterials for in vitro systems. Such artificial tissues and organs are employed in drug discovery, functional cell biological investigations, and basic research that would be ethically impossible to conduct in living women. This Roadmap is a collection of eleven sections written by leading and up-and-coming experts in this field who review and discuss four aspects of biomaterials for women’s health. These include conditions that disproportionately but not exclusively affect women (e.g., breast cancer), conditions unique to female reproductive organs, in both non-pregnant and pregnant states, and sex differences in non-reproductive tissues (e.g., the cardiovascular system). There is a strong need to develop this exciting field, with the potential to materially influence women’s lives worldwide.

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“…In recent work, the plasma technique was employed to modify the surface polymer prostheses based on the PP matrix for incorporating a coating of the poly( N -isopropylacrylamide) (PNIPAAm) hydrogel. ,− This strategy provided meshes with enhanced cell attachment and detachment modulated properties. , More recently, Learn et al also demonstrated the advantageous modification of PP meshes with cold plasma, showing that such treatment reduces fibrinogen absorption and bacteria attachment, which are both intrinsically related to the surface oxygen content.…”

Section: Introductionmentioning

confidence: 99%

“…Despite this, postsurgical problems such as mesh shrinking and foreign body reactions leading to inflammatory processes are complications associated with such biomedical materials. 10,11 On the other hand, more than 10% of patients are likely to be rehospitalized due to adhesion-related complications within 5 years of surgery, 12 and 2 to 8% of implanted meshes might become infected. 13−15 To mitigate such adverse consequences, many research efforts have been focused on altering the surface properties of synthetic meshes, either directly 16 or through the application of antiadhesion films, 17 antibiotic coatings, or fibers loaded with silver zeolites.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The selection of the mesh is carried out by surgeons for each patient, considering the kind of defect to be repaired, which is crucial to avoid or minimize postoperative complications and recurrences. Despite this, postsurgical problems such as mesh shrinking and foreign body reactions leading to inflammatory processes are complications associated with such biomedical materials. , On the other hand, more than 10% of patients are likely to be rehospitalized due to adhesion-related complications within 5 years of surgery, and 2 to 8% of implanted meshes might become infected. − To mitigate such adverse consequences, many research efforts have been focused on altering the surface properties of synthetic meshes, either directly or through the application of antiadhesion films, antibiotic coatings, or fibers loaded with silver zeolites . Also, prevention strategies, such as the incorporation of a sensor to early alert about bacterial growth, have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical Properties of Smart Polypropylene Meshes: Effects of Mesh Architecture, Plasma Treatment, Thermosensitive Coating, and Sterilization Process

Lanzalaco

Weis

Traeger

et al. 2023

ACS Biomater. Sci. Eng.

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Smart polypropylene (PP) hernia meshes were proposed to detect surgical infections and to regulate cell attachment-modulated properties. For this purpose, lightweight and midweight meshes were modified by applying a plasma treatment for subsequent grafting of a thermosensitive hydrogel, poly(N-isopropylacrylamide) (PNIPAAm). However, both the physical treatment with plasma and the chemical processes required for the covalent incorporation of PNIPAAm can modify the mechanical properties of the mesh and thus have an influence in hernia repair procedures. In this work, the mechanical performance of plasma-treated and hydrogel-grafted meshes preheated at 37 °C has been compared with standard meshes using bursting and the suture pull out tests. Furthermore, the influence of the mesh architecture, the amount of grafted hydrogel, and the sterilization process on such properties have been examined. Results reveal that although the plasma treatment reduces the bursting and suture pull out forces, the thermosensitive hydrogel improves the mechanical resistance of the meshes. Moreover, the mechanical performance of the meshes coated with the PNIPAAm hydrogel is not influenced by ethylene oxide gas sterilization. Micrographs of the broken meshes evidence the role of the hydrogel as reinforcing coating for the PP filaments. Overall, results confirm that the modification of PP medical textiles with a biocompatible thermosensitive hydrogel do not affect, and even improve, the mechanical requirements necessary for the implantation of these prostheses in vivo.

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Mesh deformation: A mechanism underlying polypropylene prolapse mesh complications in vivo

Cited by 17 publications

References 51 publications

Self-Searching Writing of Human-Organ-Scale Three-Dimensional Topographic Scaffolds with Shape Memory by Silkworm-like Electrospun Autopilot Jet

Self-Searching Writing of Human-Organ-Scale Three-Dimensional Topographic Scaffolds with Shape Memory by Silkworm-like Electrospun Autopilot Jet

Roadmap on biomaterials for women’s health

Mechanical Properties of Smart Polypropylene Meshes: Effects of Mesh Architecture, Plasma Treatment, Thermosensitive Coating, and Sterilization Process

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