Many studies have investigated age-related change in normal occlusion and during the post-retention phase of orthodontic treatment. None, however, have investigated such change in malocclusion. The purpose of this study was to compare age-related change in Angle Class I crowding with that in normal occlusion. Dental casts obtained from 10 men and 2 women in their 20s and then again in their 40s were digitized with a 3-dimensional laser scanner to measure anterior crowding, angulation, inclination, and arch width and length. A paired t-test was used to evaluate change in these values between the two sets of casts. A student's t-test was used to compare values between the crowding and normal groups. The casts obtained from individuals with untreated Angle Class I crowding revealed that anterior crowding increased with age due to a decrease in the length of the maxillary arch. Clear lingual inclination of the maxillary incisors and mesiolingual inclination of the maxillary canines were also observed. A decrease was observed in the anterior arch width and an increase in crowding due to lingual inclination of the mandibular canines in the mandible. The space between the mandibular central incisors and between the mandibular lateral incisors and canines was particularly associated with an increase in crowding, suggesting that this was age-related. A comparison between patients in their 40s with Angle Class I crowding and those with normal occlusion revealed that the increase in maxillary anterior crowding was greater in the former. Mandibular anterior crowding increased at around the same rate, however.