meso-Dihydroguaiaretic acid attenuates the neurotoxic effect of staurosporine in primary rat cortical cultures

LXR-α antagonist meso-dihydroguaiaretic acid attenuates high-fat diet-induced nonalcoholic fatty liver

“…In some in vitro studies, MDGA was reported to show potential for use against inflammation, chemical-induced neurotoxicity, and ultraviolet radiation-induced skin aging [12,14,28]. However, MDGA has not been studied extensively with regard to liver disease.…”

“…meso-Dihydroguaiaretic acid (MDGA), a dibenzylbutane lignan isolated from Machilus thunbergii, possesses anti-oxidative, antiinflammatory and anti-neurotoxic properties [12][13][14]. Because it exhibits diverse pharmacological effects with no marked toxicity, M. thunbergii has been used in traditional medicine for the treatment of various disorders including leg edema, abdominal distension and pain.…”

Meso-dihydroguaiaretic acid isolated from Saururus chinensis inhibits cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells

“…Other groups have reported that MDGA inhibits the expression of matrix metalloproteinase (MMP)-2, 9 in cultured human keratinocytes (Moon et al, 2005), downregulated TGFb-1 gene expression in activated hepatic stellate cells (Park et al, 2005), protected neuronal cells from staurosporine-induced apoptosis (Ma et al, 2006), and inhibited MMP-1 in primary human fibroblasts (Moon et al, 2006). We also reported that the ethanol extracts of S. chinensis had anti-asthmatic activity .…”

“…Neolignan derivatives isolated from this plant, which are of the tetrahydrofuran type, inhibit cell adhesion (Rho et al, 2003) and inflammation (Hwang et al, 2002;Lee et al, 2003), and are murine neuroleptics (Rao et al, 1987), hepatoprotective, and hypercholesterolemic . MDGA isolated from M. thunbergii is neuroprotective against glutamateand staurosporine-induced neurotoxicity Ma et al, 2006). However, the underlying mechanisms for the anti-inflammatory effects of MDGA have not been reported.…”

Neuroprotective phenolics in medicinal plants

“…The antioxidative characteristics of MDGA were found to contribute the observed antiapoptotic effect in staurosporine-induced neuronal cell death. In parallel, MDGA reduced staurosporine-induced caspase-3 activation and cytochrome c release (Ma et al, 2006).…”