Mesocortical BDNF signaling mediates antidepressive-like effects of lithium

Liu, Di; Tang, Qianqian; Wang, Di; Song, Su-Pei; Yang, Xiaona; Hu, Su-Wan; Wang, Zhiyong; Xu, Zheng; Li, He; Yang, Jing; Montgomery, Sarah; Zhang, Hongxing; Han, Ming–Hu; Ding, Huiping; Cao, Jun‐Li

doi:10.1038/s41386-020-0713-0

Cited by 21 publications

(3 citation statements)

References 78 publications

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“…The population of glutamatergic neurons in VTA is reported to be less than other types of neurons like GABA and DA, and we only wanted these glutamatergic projections to be NAc-specific rather than VTA glutamatergic projection to other brain regions in VGluT2-Cre mice. We used the CaMKII tracing method in the wild-type mice because CaMKII was reported to colonize predominantly with the glutamate neurons ( Zhu et al, 2014 ; Basting et al, 2018 ; Liu et al, 2020 ; Sheng et al, 2020 ; Zhang et al, 2020 ; Li et al, 2022 ). For this, a retrograde CaMKIIa-CRE viral vector was injected into the NAc, and DIO-EYFP was injected in the VTA of the wild-type mice ( Figure 1F ).…”

Section: Resultsmentioning

confidence: 99%

VTA-NAc glutaminergic projection involves in the regulation of pain and pain-related anxiety

Mannan

Yan

Zhao

et al. 2022

Front. Mol. Neurosci.

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BackgroundBesides the established role of dopamine neurons and projections in nociceptive stimuli, the involvement of ventral tegmental area (VTA) glutamatergic projections to nucleus accumbens (NAc) in pain remains unknown. In the present study, we aimed to examine the role of VTA glutamatergic projections to NAc in painful stimuli and its related behavioral changes.MethodsUnilateral chronic constrictive injury (CCI) of sciatic nerve or intraplantar hind paw injections (i.pl.) of complete Freund’s adjuvant (CFA) were used to develop pathological pain models in wild-type and VGluT2-Cre mice. The involvement of VTA glutamatergic neurons with projections to NAc in CCI-induced pain model was noted by c-Fos labeling and firing rate recordings. Pain response and pain-related behavior changes to the artificial manipulation of the VTA glutamatergic projections to NAc were observed by Hargreaves tests, von Frey tests, open field tests, elevated maze tests, and sucrose preference tests.ResultsGlutamatergic neurons in VTA had efferent inputs to shell area of the NAc. The CCI pain model significantly increased neuronal activity and firing rate in VTA glutamate neurons with projections to NAc. The photoinhibition of these glutamatergic projections relieved CCI-induced neuropathic pain and CFA-induced acute and chronic inflammatory pain. Moreover, pathological neuropathic pain-induced anxiety and less sucrose preference were also relieved by inhibiting the VTA glutamatergic projections to NAc.ConclusionTogether, glutamatergic inputs from VTA to NAc contribute to chronic neuropathic and inflammatory pain and pain-related anxiety and depressive behaviors, providing a mechanism for developing novel therapeutic methods.

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Section: Resultsmentioning

confidence: 99%

VTA-NAc glutaminergic projection involves in the regulation of pain and pain-related anxiety

Mannan

Yan

Zhao

et al. 2022

Front. Mol. Neurosci.

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“…Section 2.1 of the article suggests that a zinc-deficient diet increases the risk of depression, and in fact, appropriate zinc supplementation can help treat depression. Clinical studies have shown that zinc supplementation, individually or in combination with antidepressants, may help reduce depressive symptoms, and the dose and treatment course of zinc in clinical trials were 25~220 mg for 6 to 12 weeks [ 147 , 148 , 149 ]. In chronic stress-induced rodent models of depression, zinc supplementation can reduce depressive-like behavior [ 150 ].…”

Section: Appropriate Supplementation Of Some Mineral Elements or As M...mentioning

confidence: 99%

Appropriate Macronutrients or Mineral Elements Are Beneficial to Improve Depression and Reduce the Risk of Depression

Zhengyang

Quan

et al. 2023

IJMS

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Depression is a common mental disorder that seriously affects the quality of life and leads to an increasing global suicide rate. Macro, micro, and trace elements are the main components that maintain normal physiological functions of the brain. Depression is manifested in abnormal brain functions, which are considered to be tightly related to the imbalance of elements. Elements associated with depression include glucose, fatty acids, amino acids, and mineral elements such as lithium, zinc, magnesium, copper, iron, and selenium. To explore the relationship between these elements and depression, the main literature in the last decade was mainly searched and summarized on PubMed, Google Scholar, Scopus, Web of Science, and other electronic databases with the keywords “depression, sugar, fat, protein, lithium, zinc, magnesium, copper, iron, and selenium”. These elements aggravate or alleviate depression by regulating a series of physiological processes, including the transmission of neural signals, inflammation, oxidative stress, neurogenesis, and synaptic plasticity, which thus affect the expression or activity of physiological components such as neurotransmitters, neurotrophic factors, receptors, cytokines, and ion-binding proteins in the body. For example, excessive fat intake can lead to depression, with possible mechanisms including inflammation, increased oxidative stress, reduced synaptic plasticity, and decreased expression of 5-Hydroxytryptamine (5-HT), Brain Derived Neurotrophic Factor (BDNF), Postsynaptic density protein 95(PSD-95), etc. Supplementing mineral elements, such as selenium, zinc, magnesium, or lithium as a psychotropic medication is mostly used as an auxiliary method to improve depression with other antidepressants. In general, appropriate nutritional elements are essential to treat depression and prevent the risk of depression.

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“…The VTA itself, and more importantly, via its projections to the mPFC has been extensively studied for its contribution to aversive stimuli processing ( Gunaydin et al, 2014 ; Lammel et al, 2014 ). Functional studies have also revealed the crucial impact of this dopaminergic pathway on the regulation of anxiety and social behaviors involved in emotional stress responses ( Friedman et al, 2014 ; Liu D. et al, 2020 ). For instance, the optogenetic stimulation of the VTA-mPFC pathway in stress naïve female mice had an anxiogenic effect and triggered aversion in a conditioned place preference test ( Gunaydin et al, 2014 ).…”

Section: Functional Contributions Of the Mpfc Circuitry In Mediating Behavioral Stress Responsesmentioning

confidence: 99%

Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors

Bittar

Labonté

2021

Front. Behav. Neurosci.

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Despite decades of research on the neurobiology of major depressive disorder (MDD), the mechanisms underlying its expression remain unknown. The medial prefrontal cortex (mPFC), a hub region involved in emotional processing and stress response elaboration, is highly impacted in MDD patients and animal models of chronic stress. Recent advances showed alterations in the morphology and activity of mPFC neurons along with profound changes in their transcriptional programs. Studies at the circuitry level highlighted the relevance of deciphering the contributions of the distinct prefrontal circuits in the elaboration of adapted and maladapted behavioral responses in the context of chronic stress. Interestingly, MDD presents a sexual dimorphism, a feature recognized in the molecular field but understudied on the circuit level. This review examines the recent literature and summarizes the contribution of the mPFC circuitry in the expression of MDD in males and females along with the morphological and functional alterations that change the activity of these neuronal circuits in human MDD and animal models of depressive-like behaviors.

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Mesocortical BDNF signaling mediates antidepressive-like effects of lithium

Cited by 21 publications

References 78 publications

VTA-NAc glutaminergic projection involves in the regulation of pain and pain-related anxiety

VTA-NAc glutaminergic projection involves in the regulation of pain and pain-related anxiety

Appropriate Macronutrients or Mineral Elements Are Beneficial to Improve Depression and Reduce the Risk of Depression

Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors

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