Mesoderm Induction by Heterodimeric AP-1 (c-Jun and c-Fos) and Its Involvement in Mesoderm Formation through the Embryonic Fibroblast Growth Factor/Xbra Autocatalytic Loop during the Early Development of Xenopus Embryos

Kim, Jaebong; Lin, Jih-Jing; Xu, Ren‐He; Kung, Hsiang‐Fu

doi:10.1074/jbc.273.3.1542

Cited by 26 publications

(28 citation statements)

References 42 publications

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“…Moreover, we demonstrated that heterodimeric AP-1, comprised of c-Jun and c-Fos, mediated activin-induced Spemann organizer gene expression (15). We also reported the involvement of AP-1 in BMP-4 signaling and in BMP-4 expression (26,27). Although the role of other AP-1 components has been reported in X. laevis development, the physiological function of heterodimeric AP-1 comprised of JunD and c-Fos has not yet been elucidated in X. laevis development.…”

Section: Discussionmentioning

confidence: 71%

“…Thus, we hypothesized that the composition of AP-1 would determine the expression of specific target genes and allow prediction of the nature of the dimeric combinations, which are physiologically relevant under various conditions. Previously, we have shown that AP-1 is involved in mesoderm induction as a major downstream mediator of FGF signaling (25,26). Moreover, we demonstrated that heterodimeric AP-1, comprised of c-Jun and c-Fos, mediated activin-induced Spemann organizer gene expression (15).…”

Section: Discussionmentioning

confidence: 91%

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The Role of Heterodimeric AP-1 Protein Comprised of JunD and c-Fos Proteins in Hematopoiesis

Lee

Yoon

Lee

et al. 2012

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 91%

The Role of Heterodimeric AP-1 Protein Comprised of JunD and c-Fos Proteins in Hematopoiesis

Lee

Yoon

Lee

et al. 2012

Journal of Biological Chemistry

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“…Because the putative weak Ets consensus sites are widely distributed on the Xbra promoter, it is possible that interactions with several Ets-like sites synergistically regulate Xbra transcription. Furthermore, other transcription factors, such as AP-1, potentially participate in transcriptional regulation of Xbra (45). It is likely that other transcription factors in coordination with Ets-2 regulate Xbra transcription.…”

Section: Fig 6 Ets-2 Is Essential For Xbra Transcriptionmentioning

confidence: 99%

Essential Role of the Transcription Factor Ets-2 inXenopus Early Development

Kawachi

Masuyama

Nishida

2003

Journal of Biological Chemistry

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The fibroblast growth factor (FGF)/MAPK pathway plays an important role in early Xenopus developmental processes, including mesoderm patterning. The activation of the MAPK pathway leads to induction of Xenopus Brachyury (Xbra), which regulates the transcription of downstream mesoderm-specific genes in mesoderm patterning. However, the link between the FGF/MAPK pathway and the induction of Xbra has not been fully understood. Here we present evidence suggesting that Ets-2 is involved in the induction of Xbra and thus in the development of posterior mesoderm during early embryonic development. Overexpression of Ets-2 caused posteriorized embryos and led to the induction of mesoderm in ectodermal explants. Expression of a dominant-negative form of Ets-2 or injection of antisense morpholino oligonucleotides against Ets-2 inhibited the formation of the trunk and tail structures. Overexpression of Ets-2 resulted in the induction of Xbra, and expression of the dominant-negative Ets-2 inhibited FGFor constitutively active MEK-induced Xbra expression. Moreover, overexpression of Ets-2 up-regulated the transcription from Xbra promoter reporter gene constructs. Ets-2 bound to the Xbra promoter region in vitro. These results taken together indicate that Xenopus Ets-2 plays an essential role in mesoderm patterning, lying between the FGF/MAPK pathway and the Xbra transcription.

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“…AP-1 c-Jun/c-Fos induces the expression of the organizer and mesodermal gene, Xbra (Dong et al, 1996, Kim et al, 1998, Lee et al, 2011. In addition, AP-1 c-Jun/c-Fos regulates Zic3 expression when stimulated with activin (Lee et al, 2004).…”

Section: Fig 4 An Ap-1 Complex Composed Of C-jun and Fosb Induced Fmentioning

confidence: 99%

AP-1^c-Jun/FosBmediates xFoxD5b expression in Xenopus early developmental neurogenesis

et al. 2013

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Mesoderm Induction by Heterodimeric AP-1 (c-Jun and c-Fos) and Its Involvement in Mesoderm Formation through the Embryonic Fibroblast Growth Factor/Xbra Autocatalytic Loop during the Early Development of Xenopus Embryos

Cited by 26 publications

References 42 publications

The Role of Heterodimeric AP-1 Protein Comprised of JunD and c-Fos Proteins in Hematopoiesis

The Role of Heterodimeric AP-1 Protein Comprised of JunD and c-Fos Proteins in Hematopoiesis

Essential Role of the Transcription Factor Ets-2 inXenopus Early Development

AP-1^c-Jun/FosBmediates xFoxD5b expression in Xenopus early developmental neurogenesis

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Mesoderm Induction by Heterodimeric AP-1 (c-Jun and c-Fos) and Its Involvement in Mesoderm Formation through the Embryonic Fibroblast Growth Factor/Xbra Autocatalytic Loop during the Early Development of Xenopus Embryos

Cited by 26 publications

References 42 publications

The Role of Heterodimeric AP-1 Protein Comprised of JunD and c-Fos Proteins in Hematopoiesis

The Role of Heterodimeric AP-1 Protein Comprised of JunD and c-Fos Proteins in Hematopoiesis

Essential Role of the Transcription Factor Ets-2 inXenopus Early Development

AP-1c-Jun/FosBmediates xFoxD5b expression in Xenopus early developmental neurogenesis

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AP-1^c-Jun/FosBmediates xFoxD5b expression in Xenopus early developmental neurogenesis