Mesoglobules of thermoresponsive polymers in dilute aqueous solutions above the LCST

Aseyev, Vladimir; Hietala, Sami; Laukkanen, Antti; Nuopponen, Markus; Confortini, Ondine; Prez, Filip Du; Tenhu, Heikki

doi:10.1016/j.polymer.2005.05.097

Cited by 156 publications

(213 citation statements)

References 47 publications

Supporting

Mentioning

183

Contrasting

Order By: Relevance

“…For aggregates of PVP-PAA1 complexes at pH = 3.4, fractal dimension is 2.80 ± 0.02 and is somewhat higher than a typical value observed for RLCA regime. Similar fractal dimension was obtained recently for poly( N -isopropylacrylamide) (PNIPAM) mesoglobules by Aseyev et al [ 44 ] and Kujawa et al [ 45 ] Aggregates with the same d f were detected at x AA = 0.6. However, due to lower R g value of these particles we could not approach such a high qR g region.…”

Section: Aggregation Of Pvp-paa Interpolymer Complexessupporting

confidence: 86%

The Structure and Aggregation of Hydrogen‐Bonded Interpolymer Complexes of Poly(acrylic acid) With Poly(N‐vinylpyrrolidone) in Dilute Aqueous Solution

Henke

Kadłubowski

Wolszczak

et al. 2011

Macro Chemistry & Physics

View full text Add to dashboard Cite

Hydrogen-bonded complexation between high-molecular-weight poly( N -vinylpyrrolidone) (PVP, M -w = 650 kDa) and poly(acrylic acid) (PAA) with weight-average molar weights between 0.9 and 50 kDa, is studied in dilute, salt-free aqueous solution. The onset of complexation, aggregation, and the structure of the formed particles are strongly infl uenced by PAA molecular weight, solution composition, and the method of sample preparation. With increasing poly(acrylic acid) chain length, IPCs show higher stability against aggregation. IPCs based on high-molecular-weight PAA show core-corona architecture ensuring good sterical stabilization, whereas for those containing the shortest polyacid a loose soft-sphere structure without distinct borders of different chain densities is found.

show abstract

Section: Aggregation Of Pvp-paa Interpolymer Complexessupporting

confidence: 86%

The Structure and Aggregation of Hydrogen‐Bonded Interpolymer Complexes of Poly(acrylic acid) With Poly(N‐vinylpyrrolidone) in Dilute Aqueous Solution

Henke

Kadłubowski

Wolszczak

et al. 2011

Macro Chemistry & Physics

View full text Add to dashboard Cite

show abstract

“…A detailed review of the properties of temperature-sensitive polymers, including light scattering studies, has been published. [23] Recently, light and neutron scattering methods were exploited extensively for the investigation of these polymers, e.g., of poly(N-isopropylacrylamide) [24,25] (PNIPAM), poly(N-vinyl caprolactam) [24,26] (PVCL), poly(methyl vinyl ether) [24] (PVME), hydrophobically modified poly(N-isopropylacrylamide) (HM-PNI-PAM) [27][28][29][30][31] or of hydrophobically modified polyoxazolines. [32][33][34] Several scenarios for the structural transition in a solution during phase separation could come to life, depending on the chemical composition and concentration of the thermoresponsive polymer.…”

Section: Temperature-responsive Aggregation Behaviormentioning

confidence: 99%

Polyoxazoline Thermoresponsive Micelles as Radionuclide Delivery Systems

Hrubý

Filippov

Pánek

et al. 2010

Macromolecular Bioscience

View full text Add to dashboard Cite

Thermoresponsive polymer micelles are promising drug and radionuclide carriers with a strong passive targeting effect into solid tumors. We have synthesized ABA triblock copolymers poly[2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below the cloud point temperature (CPT) of the thermoresponsive central block and above CPT form polymer micelles at CMC 5-10 × 10(-5) g · mL(-1) with diameter ≈200 nm. The phenolic moiety introduced into the copolymer allowed radionuclide labeling with iodine-125 ongoing in good yield with sufficient in vitro stability under model conditions.

show abstract

“…[36,37] The size of the PNIPAM globules varies from 112 to 170 nm at 0.1 wt.-% if a slow heating rate (0.1 8C Á min À1 ) is applied instead of a temperature jump (Figure 2a). Such an effect is related to a slow rearrangement of the chains during the formation of the globules when the temperature reaches the cloud point.…”

Section: Particle Sizes and Cloud Pointsmentioning

confidence: 99%

Physical Gelation of Amphiphilic Poly(N‐isopropylacrylamide): Influence of the Hydrophobic Groups

Wintgens¹

2008

Macro Chemistry & Physics

View full text Add to dashboard Cite

The self‐assembling properties of hydrophobically modified (N‐isopropylacrylamide) have been investigated by dynamic light scattering and rheological measurements. Size of the globules and transmission of the solutions vary strongly in the same range of temperature. The presence of hydrophobic groups leads to contraction of the globules' size compared to poly(N‐isopropylacrylamide) (PNIPAM). The viscoelastic properties of the samples in aqueous solution have been investigated as a function of copolymer concentration, structure of the hydrophobic group (dodecyl or adamantyl group), substitution level (1–5%) and over a temperature range covering the lower critical solution temperature (LCST). At high concentration and high level of adamantyl substitution, gelation is observed several degrees before the phase transition. A physical network is formed due to the strong hydrophobic interactions, and this physical gel undergoes phase transition without macroscopic phase separation.magnified image

show abstract

Mesoglobules of thermoresponsive polymers in dilute aqueous solutions above the LCST

Cited by 156 publications

References 47 publications

The Structure and Aggregation of Hydrogen‐Bonded Interpolymer Complexes of Poly(acrylic acid) With Poly(N‐vinylpyrrolidone) in Dilute Aqueous Solution

The Structure and Aggregation of Hydrogen‐Bonded Interpolymer Complexes of Poly(acrylic acid) With Poly(N‐vinylpyrrolidone) in Dilute Aqueous Solution

Polyoxazoline Thermoresponsive Micelles as Radionuclide Delivery Systems

Physical Gelation of Amphiphilic Poly(N‐isopropylacrylamide): Influence of the Hydrophobic Groups

Contact Info

Product

Resources

About