Mesolimbic and Extrapyramidal Sites for the Mediation of Stereotyped Behaviour Patterns and Hyperactivity by Amphetamine and Apomorphine in the Rat

Costall, B.; Naylor, R.J.

doi:10.1007/978-1-4684-3087-5_3

Cited by 63 publications

(16 citation statements)

References 46 publications

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“…Lidocaine injections produce spindle discharges and seizures in the limbic system, particularly the amygdala [49,52], Similar findings have also been reported with cocaine administration [8,9], Costall and Naylor [7] have also implicated the amygdala in the mediation of some components of stereotypy and motor activity. Thompson et al [unpub., cited in ref.…”

Section: Introductionsupporting

confidence: 67%

Effect of Lidocaine Pretreatment on Cocaine-Induced Behavior in Normal and Amygdala-Lesioned Rats

Squillace¹,

Post²,

Pert³

1982

Neuropsychobiology

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Animals treated with daily lidocaine (60 mg/kg, i.p.) develop progressive increases in pathological eating of nonnutritive substances, i.e. omniphagia. Bilateral amygdala lesions blocked the development of lidocaine-induced omniphagia. Following 32 daily injections of lidocaine, both lesioned and nonlesioned animals showed greater cocaine-induced hyperactivity than saline-pretreated controls. These data suggest cross-sensitization between the two local anesthetics lidocaine and cocaine, even though lidocaine does not possess the psychomotor stimulant effects of cocaine. Amygdala-lesioned animals showed greater cocaine-induced vertical rearing activity compared to controls. The lesion data suggest that the amygdala is differentially involved in the progressive behavioral sensitization to both chronic lidocaine and cocaine.

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Section: Introductionsupporting

confidence: 67%

Effect of Lidocaine Pretreatment on Cocaine-Induced Behavior in Normal and Amygdala-Lesioned Rats

Squillace¹,

Post²,

Pert³

1982

Neuropsychobiology

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“…Although our previous observations indicated that the extracellular DA response patterns to the AMPHs in the dorsal and ventral striatum are similar (Kuczenski et al, 1991Segal and Kuczenski, 1992;Kuczenski and Segal, 1992), it is conceivable that dynamic infusions of the drug result in different temporal profiles in the two striatal regions. This possibility is particularly important since a great deal of converging evidence suggests that stimulant effects on DA transmission in the dorsal and ventral striatum modulate different behavioral components of the stimulant response (Roberts et al, 1975;Costall and Naylor, 1977;Swerdlow et al, 1986;Dickson et al, 1994). Therefore, changes we observed in the relative expression of locomotion and stereotypy, both within and between days may have been due, at least partially, to different region-related effects on the pattern of DA transmission.…”

Section: Da-behavior Relationshipsmentioning

confidence: 94%

Human Methamphetamine Pharmacokinetics Simulated in the Rat: Single Daily Intravenous Administration Reveals Elements of Sensitization and Tolerance

Segal

Kuczenski

2005

Neuropsychopharmacol

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We developed a computer-controlled intravenous methamphetamine (METH) administration procedure (dynamic infusion), which enables us to compensate for an important pharmacokinetic difference between rats and humans by imposing a 12-h half-life for the drug in rats. Dynamic infusion of 0.5 mg/kg METH produced a pharmacokinetic profile that closely simulates the METH exposure pattern in humans, including an apparent half-life of 11.671.3 h, and an area under the concentration vs time curve of 9.4 mM h, about 20-fold larger than results obtained with typical rat pharmacokinetics. Using this procedure, METH produced a prolonged behavioral stimulation and elevation in caudate extracellular dopamine (DA). Both the behavioral and the DA effects exhibited tolerance to the sustained plasma METH exposure. Single daily dynamic infusion of 0.5 mg/kg METH for 15 days resulted in a progressive enhancement of the behavioral response until about Day 10. On subsequent days, in addition to continued evidence of sensitization, tolerance in the form of a marked decrease in the duration of the behavioral activation became a prominent feature of the response. Qualitative changes in the behavior also emerged. Resumption of METH treatment following 4 days of withdrawal revealed that sensitization was apparent during the first dynamic infusion, and that tolerance re-emerged within two additional days of drug administration. These results showed that a humanlike METH exposure pattern produced behavioral and striatal DA response profiles that are both quantitatively and qualitatively different from the effects typically observed with single daily METH injections in rats. Thus, simulation of human METH exposure patterns may be a critical prerequisite to identifying mechanisms relevant to the chronic use of this drug in humans. Neuropsychopharmacology (2006) 31, 941-955.

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“…Animals subjected to these treatments developed, over multiple daily binges, a unique pattern of behavioral response that included elements of both tolerance (stereotypy response) and sensitization (locomotor response) (Segal and Kuczenski, 1997a). Because of the involvement of mesolimbic and mesostriatal dopamine (DA) pathways in locomotion and stereotypy, respectively (Roberts et al, 1975;Kelly and Iversen, 1976;Costall and Naylor, 1977;Sessions et al, 1980;Swerdlow et al, 1986), we hypothesized that a persistent shift in the relative magnitude of caudate-putamen (CP) and nucleus accumbens (NAC) DA transmission may contribute to the altered behavioral profile associated with this escalating dosebinge pattern of drug administration (Segal and Kuczenski, 1997a). To test this hypothesis, we examined the CP and NAC DA response profiles to multiple high-dose AMPH binges.…”

mentioning

confidence: 99%

An Escalating Dose/Multiple High-Dose Binge Pattern of Amphetamine Administration Results in Differential Changes in the Extracellular Dopamine Response Profiles in Caudate-Putamen and Nucleus Accumbens

Kuczenski

Segal

1997

J. Neurosci.

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Amphetamine (AMPH)-induced psychosis is most frequently associated with a chronic high-dose "binge" or "run" pattern of stimulant abuse, generally preceded by a period of gradually escalating doses of the drug. We showed previously that animals subjected to such a regimen of AMPH administration developed, over multiple daily binges, a unique pattern of behavioral response that included a decrease in stereotypy and a pronounced increase in locomotion. Because of the involvement of mesolimbic and mesostriatal dopamine (DA) pathways in locomotion and stereotypy, respectively, we hypothesized that a persistent shift in the relative magnitude of caudateputamen (CP) and nucleus accumbens (NAC) DA transmission may contribute to this altered behavioral profile. To test this hypothesis, we examined CP and NAC extracellular DA in response to multiple high-dose AMPH binges. Our results revealed that with multiple binges the CP DA response but not the NAC response developed a profound tolerance/tachyphylaxis to the drug-induced increase in extracellular transmitter. These differential regional response alterations seem to correspond to the shift in the relative expression of stereotypy and locomotion. We hypothesize that changes in DA synthesis, perhaps mediated by regionally specific adaptations in DA autoreceptor function, contribute to the differential extracellular transmitter response profiles, and suggest that these neurochemical changes may have important implications for the mechanisms underlying the addictive and psychotogenic properties of AMPH.

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Mesolimbic and Extrapyramidal Sites for the Mediation of Stereotyped Behaviour Patterns and Hyperactivity by Amphetamine and Apomorphine in the Rat

Cited by 63 publications

References 46 publications

Effect of Lidocaine Pretreatment on Cocaine-Induced Behavior in Normal and Amygdala-Lesioned Rats

Effect of Lidocaine Pretreatment on Cocaine-Induced Behavior in Normal and Amygdala-Lesioned Rats

Human Methamphetamine Pharmacokinetics Simulated in the Rat: Single Daily Intravenous Administration Reveals Elements of Sensitization and Tolerance

An Escalating Dose/Multiple High-Dose Binge Pattern of Amphetamine Administration Results in Differential Changes in the Extracellular Dopamine Response Profiles in Caudate-Putamen and Nucleus Accumbens

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