Mesolimbic dopaminergic neurons innervating the hippocampal formation in the rat: a combined retrograde tracing and immunohistochemical study

Gasbarri, Antonella; Verney, Catherine; Innocenzi, R.; Campana, Elena; Pacitti, C

doi:10.1016/0006-8993(94)90512-6

Cited by 263 publications

(177 citation statements)

References 38 publications

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“…Dopamine neurons densely innervate the striatum, the amygdala and the frontal cortex, while according to some anatomical studies in the rat, only ∼15% of VTA and SN neurons that project to the hippocampus are dopaminergic (Fields et al, 2007;Gasbarri et al, 1994). This raises the possibility that hippocampal dopamine may also stem from sources other than the SN, such as the LC itself (Smith and Greene, 2012), because dopaminergic and noradrenergic systems are uniquely intertwined in hippocampal circuits (see Section 2.1).…”

Section: Box 2: Role Of Sleep In the Consolidation And Generalizationmentioning

confidence: 99%

Influence of reward motivation on human declarative memory

Miendlarzewska

Bavelier

Schwartz

2016

Neuroscience & Biobehavioral Reviews

150

134

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a b s t r a c tMotivational relevance can prioritize information for memory encoding and consolidation based on reward value. In this review, we pinpoint the possible psychological and neural mechanisms by which reward promotes learning, from guiding attention to enhancing memory consolidation. We then discuss how reward value can spill-over from one conditioned stimulus to a non-conditioned stimulus. Such generalization can occur across perceptually similar items or through more complex relations, such as associative or logical inferences. Existing evidence suggests that the neurotransmitter dopamine boosts the formation of declarative memory for rewarded information and may also control the generalization of reward values. In particular, temporally-correlated activity in the hippocampus and in regions of the dopaminergic circuit may mediate value-based decisions and facilitate cross-item integration. Given the importance of generalization in learning, our review points to the need to study not only how reward affects later memory but how learned reward values may generalize to related representations and ultimately alter memory structure.

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Section: Box 2: Role Of Sleep In the Consolidation And Generalizationmentioning

confidence: 99%

Influence of reward motivation on human declarative memory

Miendlarzewska

Bavelier

Schwartz

2016

Neuroscience & Biobehavioral Reviews

150

134

View full text Add to dashboard Cite

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“…It is well established that dopaminergic reward circuitry in the brain, that is, dopaminergic projections from the midbrain ventral tegmental area (VTA) to the nucleus accumbens (NAc) and frontal cortex, plays an important role in drug addiction by enhancing dopamine efflux in the NAc, either directly or indirectly (Koob et al 1992;Spanagel and Weiss 1999). The hippocampus, on the other hand, is positioned to influence brain reward pathways by receiving inputs from both the NAc and VTA and establishing a feedback loop through efferent projections to the NAc (Gasbarri et al 1991(Gasbarri et al , 1994Floresco et al 2001;Bannerman et al 2004). These neuroanatomical observations suggesting that the hippocampus interacts with reward circuitry were further substantiated by functional studies showing that manipulations of hippocampal subfields alter the firing of VTA dopaminergic cells and dopaminergic responses in NAc (Mitchell et al 2000;Floresco et al 2001;Charara and Grace 2003;Won et al 2003;Zornoza et al 2005a,b).…”

Section: Drug Abuse and Addictionmentioning

confidence: 99%

Adult Neurogenesis and Psychiatric Disorders

Kang

Wen

Song

et al. 2016

Cold Spring Harb Perspect Biol

164

118

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Psychiatric disorders continue to be among the most challenging disorders to diagnose and treat because there is no single genetic or anatomical locus that is causative for the disease. Current treatments are often blunt tools used to ameliorate the most severe symptoms, at the risk of disrupting functional neural systems. There is a critical need to develop new therapeutic strategies that can target circumscribed functional or anatomical domains of pathology. Adult hippocampal neurogenesis may be one such domain. Here, we review the evidence suggesting that adult hippocampal neurogenesis plays a role in emotional regulation and forms of learning and memory that include temporal and spatial memory encoding and context discrimination, and that its dysregulation is associated with psychiatric disorders, such as affective disorders, schizophrenia, and drug addiction. Further, adult neurogenesis has proven to be an effective model to investigate basic processes of neuronal development and converging evidence suggests that aberrant neural development may be an etiological factor, even in late-onset diseases. Constitutive neurogenesis in the hippocampus of the mature brain reflects large-scale plasticity unique to this region and could be a potential hub for modulation of a subset of cognitive and affective behaviors that are affected by multiple psychiatric disorders.

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“…Hippocampal cholinergic nerve terminals originate from the medial septum and the vertical limb of the diagonal band of Broca and project to the hippocampal formation via the fimbria fornix (Mesulam et al, 1983;Woolf, 1991). The hippocampus also receives dopaminergic projections arising mainly from the ventral tegmental area with little contribution of the substantia nigra, pars compacta (Gasbarri et al, 1994;Verney et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

Reduction in Acetylcholine Release in the Hippocampus of Dopamine D5 Receptor-Deficient Mice

Laplante

Sibley

Quirion

2004

Neuropsychopharmacol

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Activation of the dopamine D 1 -like receptor stimulates acetylcholine (ACh) release in the hippocampus, apparently through the molecularly defined d5 receptor. In the present study, we used a transgenic mouse completely deprived of functional d5 receptor (d5À/À) to confirm the role and elucidate the possible function of the d5 receptor subtype on hippocampal cholinergic neurotransmission. ACh release was measured using in vivo microdialysis in the mouse dorsal hippocampus of 4 months old homozygous (d5À/À), heterozygous (d5 þ /À), and the wild-type (d5 þ / þ ) littermates. Using the no net flux technique, a significant reduction in basal hippocampal ACh level was found in the d5À/À compared to d5 þ /À and d5 þ / þ mice. Moreover, the administration of SKF 38393, a D 1 -like receptor agonist, systemically (2.0 and 10.0 mg/kg ip), or locally through the dialysis probe (10 and 50 mM), produced a dose-dependent enhancement of ACh release in the d5 þ / þ , a moderate stimulation in the d5 þ /À but had no effect in the d5À/À mice. Quantitative receptor autoradiography revealed significant increases in M 1 -like but not in M 2 -like muscarinic receptor binding sites in the hippocampal formation. These results confirm and extend the role of the d5 receptor in the modulation of hippocampal ACh release and provide evidence for long-term alteration of hippocampal cholinergic neurotransmission resulting from the absence of the d5 receptors including chronically reduced ACh release and change in M 1 -like receptor levels.

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Mesolimbic dopaminergic neurons innervating the hippocampal formation in the rat: a combined retrograde tracing and immunohistochemical study

Cited by 263 publications

References 38 publications

Influence of reward motivation on human declarative memory

Influence of reward motivation on human declarative memory

Adult Neurogenesis and Psychiatric Disorders

Reduction in Acetylcholine Release in the Hippocampus of Dopamine D5 Receptor-Deficient Mice

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