Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release

Schott, Björn H.; Minuzzi, Luciano; Krebs, Ruth M.; Elmenhorst, David; Lang, Markus; Winz, Oliver; Seidenbecher, Constanze I.; Coenen, Heinz H.; Heinze, Hans‐Jochen; Zilles, Karl; Düzel, Emrah; Bauer, Andreas

doi:10.1523/jneurosci.2058-08.2008

Cited by 451 publications

(397 citation statements)

References 57 publications

(83 reference statements)

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“…Moreover, phMRI studies have shown that dopamine releasing agents or agents that block dopamine reuptake increase the BOLD signal in NAc (for review, Knutson and Gibbs, 2007) and that unilateral lesions of dopamine neurons in rat striatum abolished this effect (Chen et al, 1997;Chen et al, 1999;Knutson and Gibbs, 2007). Similarly, a neuroimaging study combining [ 11 C]raclopride positron emission tomography and fMRI showed a strong correlation between BOLD activation during reward anticipation and reward-related dopamine release in the ventral striatum in humans performing a monetary incentive delay task (Schott et al, 2008). Further confirmation of the role of dopaminergic activity in the generation of amperometric O 2 responses in the NAc can be obtained with studies involving coupling of O 2 amperometric responding with pharmacological and/or electrophysiological manipulations.…”

Section: Physiological Origin Of the O 2 Signalmentioning

confidence: 99%

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

et al. 2012

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a b s t r a c t a r t i c l e i n f oReal-time in vivo oxygen amperometry, a technique that allows measurement of regional brain tissue oxygen (O 2 ) has been previously shown to bear relationship to the BOLD signal measured with functional magnetic resonance imaging (fMRI) protocols. In the present study, O 2 amperometry was applied to the study of reward processing in the rat nucleus accumbens to validate the technique with a behavioural process known to cause robust signals in human neuroimaging studies. After acquisition of a cued-lever pressing task a robust increase in O 2 tissue levels was observed in the nucleus accumbens specifically following a correct lever press to the rewarded cue. This O 2 signal was modulated by cue reversal but not lever reversal, by differences in reward magnitudes and by the motivational state of the animal consistent with previous reports of the role of the nucleus accumbens in both the anticipation and representation of reward value. Moreover, this modulation by reward value was related more to the expected incentive value rather than the hedonic value of reward, also consistent with previous reports of accumbens coding of "wanting" of reward. Altogether, these results show striking similarities to those obtained in human fMRI studies suggesting the use of oxygen amperometry as a valid surrogate for fMRI in animals performing cognitive tasks, and a powerful approach to bridge between different techniques of measurement of brain function.

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Section: Physiological Origin Of the O 2 Signalmentioning

confidence: 99%

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

et al. 2012

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“…There is ample neuroimaging evidence of the involvement of these areas in tasks that tap the use of rewards to make decisions, especially the ventral striatum (Abler, Walter, Erk, Kammerer, & Spitzer, 2006;Knutson, Taylor, Kaufman, Peterson, & Glover, 2005;Liu, et al, 2011;O'Doherty, Deichmann, Critchley, & Dolan, 2002;Pagnoni, Zink, Montague, & Berns, 2002;Rolls, McCabe, & Redoute, 2008;Schott et al, 2008). In addition, there is recent support for the idea that these areas are functionally connected during reward tasks (Camara, Rodriguez-Fornells, & Munte, 2009;Krebs, Heipertz, Schuetze, & Duzel, 2011;Ye, Hammer, Camara, & Munte, 2011), and rest (Cauda et al, 2011).…”

Section: The Reward Network (Rn)mentioning

confidence: 99%

Age differences in default and reward networks during processing of personally relevant information

Grady

Grigg

2012

Neuropsychologia

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We recently found activity in default mode and reward-related regions during self-relevant tasks in young adults. Here we examine the effect of aging on engagement of the default network (DN) and reward network (RN) during these tasks. Previous studies have shown reduced engagement of the DN and reward areas in older adults, but the influence of age on these circuits during selfrelevant tasks has not been examined. The tasks involved judging personality traits about one's self or a well known other person. There were no age differences in reaction time on the tasks but older adults had more positive Self and Other judgments, whereas younger adults had more negative judgments. Both groups had increased DN and RN activity during the self-relevant tasks, relative to non-self tasks, but this increase was reduced in older compared to young adults. Functional connectivity of both networks during the tasks was weaker in the older relative to younger adults. Intrinsic functional connectivity, measured at rest, also was weaker in the older adults in the DN, but not in the RN. These results suggest that, in younger adults, the processing of personally relevant information involves robust activation of and functional connectivity within these two networks, in line with current models that emphasize strong links between the self and reward. The finding that older adults had more positive judgments, but weaker engagement and less consistent functional connectivity in these networks, suggests potential brain mechanisms for the "positivity bias" with aging.

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“…Blood oxygen level-dependent (BOLD) signal increases in VS have been frequently elicited by reward-predictive signals or reward deliveries during functional magnetic resonance imaging (fMRI), and this has been inferred as a marker of phasic dopaminergic activity (Knutson et al, 2001). Notably, individual differences in VS recruitment by reward anticipation (assessed with fMRI) during a monetary incentive delay (MID) task correlated with individual differences in displacement of 11 C raclopride in the VS by MID task rewards themselves (Schott et al, 2008), and with displacement of 18 F fallypride by amphetamine (Buckholtz et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Dietary Tyrosine/Phenylalanine Depletion Effects on Behavioral and Brain Signatures of Human Motivational Processing

Bjork

Grant

Chen

et al. 2013

Neuropsychopharmacol

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Dopamine (DA) neurotransmission is critical for motivational processing. We assessed whether disruption of DA synthesis in healthy controls using an amino-acid beverage devoid of catecholamine precursors (tyrosine-phenylalanine depletion (TPD)) would blunt recruitment of the nucleus accumbens (NAcc) by rewards. Sixteen controls ingested each of a tyr/phe-depleting beverage (DEP) or a tyr/ phe-balanced (BAL) control beverage in two laboratory visits. Five hours after consumption of each drink, subjects underwent functional magnetic resonance imaging while they viewed anticipatory cues to respond to a target to either win money or avoid losing money. TPD did not exert main effects on mood or on task behavior, but affected brain activation. In right NAcc, TPD blunted activation by anticipation of high rewards. In left NAcc, recruitment anticipating high rewards was modulated by individual differences in mood change across the DEP drink day, where subjects whose mood worsened following TPD (relative to within-day mood change under BAL conditions) also showed lower activation under DEP conditions relative to BAL conditions. Exploratory analysis indicated that TPD qualitatively blunted the voxel-wise spatial extent of suprathreshold activation by reward anticipation. Finally, loss outcomes activated anterior insula under DEP conditions but not under BAL conditions. These data indicate that: (1) dietary depletion of catacholamine precursors will blunt dopaminergic mesolimbic activity, and (2) in controls, synthetic pathways of this neurocircuitry maintain sufficient buffering capacity to resist an effect on motivated behavior. Additional studies are needed to determine if clinical populations would show similar resistance to behavioral effects of TPD.

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Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release

Cited by 451 publications

References 57 publications

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

Age differences in default and reward networks during processing of personally relevant information

Dietary Tyrosine/Phenylalanine Depletion Effects on Behavioral and Brain Signatures of Human Motivational Processing

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