2019
DOI: 10.1038/s41598-019-40935-6
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Mesolimbic white matter connectivity mediates the preference for sweet food

Abstract: Dopaminergic brain structures like the nucleus accumbens (NAc) are thought to encode the incentive salience of palatable foods motivating appetitive behaviour. Animal studies have identified neural networks mediating the regulation of hedonic feeding that comprise connections of the NAc with the ventral tegmental area (VTA) and the lateral hypothalamus (LH). Here, we investigated how structural connectivity of these pathways relates to individual variability in decisions on sweet food consumption in humans. We… Show more

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Cited by 10 publications
(7 citation statements)
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“…However, the connection between the mesolimbic system and other brain regions may also have a neuropsychological effect, such as the trait impulsivity and sensation-seeking that are regulated by the connection between the mesolimbic and the prefrontal cortex [ 49 ]. The connection of the nucleus accumbens with the ventral tegmental area and the lateral hypothalamus in mesolimbic system could cause hedonic feeding as well [ 50 ]. Although we did not find significant TSPO change in other regions, the NI occurred in the mesolimbic regions might involve them by other ways to influence the withdrawal behavior.…”
Section: Discussionmentioning
confidence: 99%
“…However, the connection between the mesolimbic system and other brain regions may also have a neuropsychological effect, such as the trait impulsivity and sensation-seeking that are regulated by the connection between the mesolimbic and the prefrontal cortex [ 49 ]. The connection of the nucleus accumbens with the ventral tegmental area and the lateral hypothalamus in mesolimbic system could cause hedonic feeding as well [ 50 ]. Although we did not find significant TSPO change in other regions, the NI occurred in the mesolimbic regions might involve them by other ways to influence the withdrawal behavior.…”
Section: Discussionmentioning
confidence: 99%
“…This approach served to obtain a similar range of Euclidean distances and replaced multiplication of the ODFs by a constant as proposed in the original paper 17 . The optimal number of clusters was evaluated between k = [2,3,4,5,6] as observed in the literature, by minimizing the Davies-Bouldin index 43 in 20 randomly selected participants. The Davies-Bouldin index measures similarity as the ratio of within-cluster to between-cluster distances and is a commonly used method to determine a proper number of clusters.…”
Section: Segmentation Of the Hypothalamus Hypothalamus Extractionmentioning
confidence: 99%
“…The hypothalamus plays a central role in controlling bodily functions, such as endocrine activity, food intake, and energy homeostasis 1 , 2 and hypothalamic abnormalities have been linked to behavioral dysfunctions in these domains 3 . For example, research suggests that functional connections between the insula and hypothalamus are related to obesity 1 , 4 , indicating compromised mechanisms of food intake control.…”
Section: Introductionmentioning
confidence: 99%
“…The amygdala, hippocampus, and nucleus accumbens are regions involved in the reward circuitry of the brain, and their connection to the (lateral) hypothalamus via dopaminergic pathways is well established [50,51]. It would be possible that functional coupling between these areas and the hypothalamus is associated with alterations in the functional processing of food in obesity, possibly reflecting greater hedonic involvement.…”
Section: Discussionmentioning
confidence: 99%