Mesona chinensis polysaccharide/zein nanoparticles to improve the bioaccesibility and in vitro bioactivities of curcumin

Yang, Jin; Lin, Jieqiong; Chen, Xianxiang; Rong, Liyuan; Shen, Mingyue; Wang, Yuanxing; Xie, Jianhua

doi:10.1016/j.carbpol.2022.119875

Cited by 52 publications

(18 citation statements)

References 41 publications

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“…In others’ work, natural polymers such as hyaluronic acid, pectin, carboxymethyl chitosan, carboxymethyl dextrin, soybean polysaccharide, and gum have been selected to stabilize ZNPs. The soybean polysaccharides-stabilized ZNPs exhibited good pH and ionic strength stability, the carboxymethyl dextrin-involved ZNPs displayed higher encapsulation efficiency for Cur than either zein or carboxymethyl dextrin individual, and the casein/κ-carrageenan-modified ZNPs showed good thermal and ionic strength stability of quercetin. , Currently, some of the zein nanoparticles coated with other materials show slightly larger particle sizes (>140 nm). − However, it has been reported that reducing the size of nanoparticles can extend the residence time of the encapsulated materials in the gastrointestinal tract and improve the intake efficiency . Therefore, the development of nanoparticles with smaller sizes needs to be focused.…”

Section: Introductionmentioning

confidence: 99%

Carboxymethylpachymaran-Coated Zein Nanoparticles for Oral Delivery of Curcumin: Formation, Characterization, Physicochemical Stability, and Controlled Release Properties

Wang

Liang

Hou

et al. 2023

ACS Food Sci. Technol.

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The instability and poor solubility of curcumin limit its intake in the human body. In this work, curcuminencapsulated carboxymethylpachymaran/zein composite nanoparticles (ZMCNPs) were prepared by anti-solvent precipitation, and the morphology of composite nanoparticles was confirmed by transmission electron microscopy, and the interaction between carboxymethylpachymaran, zein, and curcumin was explored by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and differential scanning calorimetry. The encapsulation efficiency of curcumin by ZMCNPs (83.2%) was significantly higher than that of zein-curcumin nanoparticles (ZCNPs) (44.9%). The ZMCNPs also exhibit high ionic strength tolerance and light, heat, and storage stability. The in vitro release showed that ZMCNPs could effectively prevent the premature release of curcumin in the stomach (9.5%), while curcumin was better sustained in the small intestine stage (47.9%). Finally, the result of cytotoxicity assay in IEC-6 cells and HT-29 cells indicated the good biocompatibility of the ZMCNPs. Therefore, our study may provide some novel options for delivering biologically active substances.

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Section: Introductionmentioning

confidence: 99%

Carboxymethylpachymaran-Coated Zein Nanoparticles for Oral Delivery of Curcumin: Formation, Characterization, Physicochemical Stability, and Controlled Release Properties

Wang

Liang

Hou

et al. 2023

ACS Food Sci. Technol.

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“…Therefore, our findings suggested that a higher content of TSP in Z/T-Cur might be more effective in encapsulating curcumin. 10…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, our findings suggested that a higher content of TSP in Z/T-Cur might be more effective in encapsulating curcumin. 10 3.3 In vivo therapeutic effect on DSS-induced colitis in the mice 3.3.1 Results of the body weight, DAI score, colon length, and MPO in the mice. A DSS-induced mouse model of UC was utilized to assess the therapeutic effects of Zein-Cur, TSP-Cur, and Zein-TSP-Cur complexes on UC.…”

Section: Food and Function Papermentioning

confidence: 99%

“…Examples of such nanocarriers include dextran-zeincurcumin nanoconjugate, zein/hydroxypropyl-beta-cyclodextrin nanoparticles, zein-chitosan nanoparticles, zein/Mesona chinensis polysaccharide nanoparticles, etc. [9][10][11][12] Tamarind seed polysaccharide (TSP), a galactoxyloglucan, is composed of a D-glucan backbone with α-D-xylopyranose and β-D-galactopyranosyl side chains. 13 It possesses the ability to form a highly viscous gel with excellent pH tolerance, thermal stability, and shear resistance.…”

Section: Introductionmentioning

confidence: 99%

“…Examples of such nanocarriers include dextran–zein–curcumin nanoconjugate, zein/hydroxypropyl-beta-cyclodextrin nanoparticles, zein–chitosan nanoparticles, zein/ Mesona chinensis polysaccharide nanoparticles, etc . 9–12…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of zein–tamarind seed polysaccharide–curcumin nanocomplexes: their characterization and impact on alleviating colitis and gut microbiota dysbiosis in mice

Xie,

Zhu,

Zeng

et al. 2024

Food Funct.

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Resveratrol‐loaded pH‐responsive Mesona chinensis polysaccharides‐zein nanoparticles for effective treatment of ulcerative colitis

Yang,

Lin,

Zhang

et al. 2024

J Sci Food Agric

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BACKGROUNDResveratrol (Res) is promising food functional factor with favorable antioxidant and anti‐inflammatory properties, although its poor water solubility and low bioavailability limit extensive application. Therefore, in combination with another promising polysaccharide (Mesona chinensis polysaccharides, MCP), Res‐loaded food nanocarriers (ResNPs) were developed to increase its water solubility, bioactivity and targeting properties. ResNPs were then applied to alleviate dextran sulfate sodium (DSS)‐induced ulcerative colitis.RESULTSResveratrol can be well encapsulated in MCP‐based nanoparticles in an amorphous state, improving its water solubility. ResNPs showed pH‐response controlled release behavior in the gastrointestinal tract and increased the enrichment of Res in the colon. In vivo experiments of ResNPs against DSS‐induced ulcerative colitis (UC) revealed that ResNPs significantly improved UC symptoms, modulated intestinal inflammation and down‐regulated oxidative stress levels compared to free Res. ResNPs also play an positive role with respect to inhibiting the mitogen‐activated protein kinase pathway and promoting the expression of tight junction proteins. In addition, ResNPs improved the species composition and relative abundance of intestinal flora in UC mice, which effectively regulated the balance of intestinal flora and promoted the production of short‐chain fatty acids.CONCLUSIONThese results suggest that MCP‐based nanoparticles can effectively improve the solubility of resveratrol and enhance its in vivo bioactivity. Moreover, the present study also provides a new strategy for the prevention and treatment of UC with food polyphenol. © 2024 Society of Chemical Industry.

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Mesona chinensis polysaccharide/zein nanoparticles to improve the bioaccesibility and in vitro bioactivities of curcumin

Cited by 52 publications

References 41 publications

Carboxymethylpachymaran-Coated Zein Nanoparticles for Oral Delivery of Curcumin: Formation, Characterization, Physicochemical Stability, and Controlled Release Properties

Carboxymethylpachymaran-Coated Zein Nanoparticles for Oral Delivery of Curcumin: Formation, Characterization, Physicochemical Stability, and Controlled Release Properties

Fabrication of zein–tamarind seed polysaccharide–curcumin nanocomplexes: their characterization and impact on alleviating colitis and gut microbiota dysbiosis in mice

Resveratrol‐loaded pH‐responsive Mesona chinensis polysaccharides‐zein nanoparticles for effective treatment of ulcerative colitis

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