Mesonephric adenocarcinoma of the uterine corpus with intracystic growth completely confined to the myometrium: a case report and literature review

Ando, Hiroka; Watanabe, Yuko; Ogawa, Minori; Tamura, Hiromi; Deguchi, Tomomi; Ikeda, Kayo; Fujitani, Mayumi; Shioji, Mitsunori; Tsujie, Tomoko; Doi, Ryohei; Wakimoto, Akinori; Adachi, Shiro

doi:10.1186/s13000-017-0655-y

Cited by 20 publications

(24 citation statements)

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“…Mesonephric adenocarcinoma (MNAC) is a rare carcinoma that originates from mesonephric remnant of the female genital tract [1][2][3] , and are predominantly located on the lateral walls of the cervix and vagina [4] . Of the cases reported to date, the vast majority of MNAC are from uterine cervix [1,2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] ., , comprising<1% of all carcinomas at this site [20] , several cases of MNAC are from ovary [21][22][23][24] , and rare cases are from vagina [4,7,[25][26][27][28][29] and uterine corpus [4,11,21,[30][31][32][33][34][35][36][37][38][39][40]…”

Section: Introductionmentioning

confidence: 99%

“…But because of the limited number of cases reported, less is known regarding the clinical outcomes of UB-MNAC. Most publications on UB-MNAC are individual case reports or case series [4,11,21,[30][31][32][33][34][35][36][37][38][39][40][41][42][43] . A recent case series reported 11 cases of UB-MNAC , by investigating the clinicopathologic details, they concluded UB-MNAC displays an aggressive biological behavior, with a tendency to metastasize to the lungs [39] .…”

Section: Introductionmentioning

confidence: 99%

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Mesonephric Adenocarcinoma Arising From The Uterine Corpus：Case Reports and Literature Review

Hu¹,

Xu²,

Deng³

et al. 2020

Preprint

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Abstract Background Mesonephric adenocarcinoma (MNAC) is a rare carcinoma which arises from the mesonephric remnant of the gynecologic tract. It mainly occurs in the uterine cervix, barely locates in the uterine corpus, ovarian and vagina. To date, only a few cases of MNAC arising from of the uterine body (UB-MNAC) have been reported, and the clinicopathologic and molecular characteristics of UB-MNAC remain limited. A recent report suggested that series of UB-MNAC should be defined as Mesonephric-like adenocarcinoma carcinomas (MLAC), for they exhibited the classic morphologic features and immunophenotype of mesonephric carcinoma, but occurring outside of the cervix and without convincing mesonephric remnants. Thus, the histogenesis of UB-MNAC is not yet clear, they may originate in Müllerian tissue and exhibits the mesonephric differentiation phenotype, or arise from the mesonephric remnants in the uterine wall.Case presentation To better understand the histogenesis of UB-MNAC, we presented three UB-MNAC cases from west china second university hospital, which exhibited typical morphologic, histologic as well as the immunohistochemical characteristics of MNAC. Notably, among the three cases, two cases arising from the myometrium layer of the uterine corpus found mesonephric remnants around the tumor. By reviewing the published UB-MNAC and UB-MLAC, we found that to our knowledge ,it is the first time finding mesonephric remnants around the MNAC cells in the reported literature, except one case that found mesonephric remnants in the cervix, and the tumors of the three cases were all arising from the myometrium layer, without endometrium involved. Then we compared the clinical characteristics of the UB-MNAC cases arising from the myometrium and endometrium, and the results showed that the two subgroups had most in common in the clinical characteristics except the myometrium subgroup had a higher elevated CA125 level, and this result was in consistent with the Kaplan-Meier survival analysis, which indicated that the myometrium subgroup had a poorer prognosis than the endometrium group. But this need more data and further study such as the molecular analysis.Conclusion Though the pathogenesis of MLAC or MNAC of the uterine corpus is still under debate, according to our cases and the published literatures, We hypothesize two different pathways involved: the MNAC arising from the myometrium not affecting the endometrium may directly develop from the mesonephric remnant, the one occurred in the endometrium may not real mesonephric adenocarcinoma, but more likely arising from mesonephric transformation of Müllerian adenocarcinoma, and is better referred as MLAC. Besides, the two kinds of adenocarcinomas may have different clinical prognosis, while the MNAC arising from the myometrium may have a poorer prognosis than the MLAC originating from the endometrium, although they have identical morphologic and histologic characteristics.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mesonephric Adenocarcinoma Arising From The Uterine Corpus：Case Reports and Literature Review

Hu¹,

Xu²,

Deng³

et al. 2020

Preprint

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“…Certain data [2] determine that close shape-generating interrelations are established between the mesenchymal membrane of the paramesonephral ducts and caudal ligament of mesonephros (Wolffian body/inguinal fold) on the eighth week of development. Some other data determined [3] that the mucous membrane of the uterine tubes during early reproductive age is covered with simple columnar epithelium with a small amount of ciliated and secretory cells available. Single lymphocytes are found in the submucous layer.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of the uterine tubes in the fetal period: topographic and morphometric parallels

Проняєв

Bulyk

2019

Rep. of Morph.

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Topicality of the study is stipulated by the importance of objective data for medicine concerning formation of the structure and topographic-anatomical interrelations of the uterine tubes with adjacent organs and structures during the prenatal period of human ontogenesis. Objective: to find and compare tendencies of changes of the uterine tube morphologic parameters in the two groups of fetuses remote in time, and determine age peculiarities of their topography during perinatal period of development. The experimental material (specimens of fetuses) was divided into two groups: І group – 35 specimens of fetuses deceased during 2017-2019; ІІ group – 105 specimens of fetuses taken from the Museum of the Departments of Anatomy, Clinical Anatomy and Operative Surgery at Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, collected during 1970-1990. Every group was subdivided into 7 subgroups according to 10 months of the fetal period of development (from the 4th to the 10th months). The results obtained were statistically processed in the licensed statistical package “Statistica 6.0” using nonparametric methods to evaluate the results. Regular changes in the topography of the right and left uterine tubes, changes in their shape and histological structure are observed. Both uterine tubes were found to occupy an ascending position in thirty cases out of sixty examined specimens of early fetuses (4-6 months of age). In twenty cases one uterine tube was found to be in an ascending position, and in ten cases both uterine tubes were placed practically horizontally. The study of uterine tube morphogenesis in 7-month fetuses found that the structure and topography of the uterine tubes in different age periods differ. In two 7-month fetuses the uterine tubes were found to be in an ascending position, in eight cases one uterine tube (the left one – in six cases out of eight) was in a horizontal position, and in ten cases two uterine tubes were directed practically horizontally. During the 8th month of the antenatal development one uterine tube was found to be in an ascending position out of eight cases; in ten cases both uterine tubes were in the position close to a horizontal one; and in two cases the left uterine tube was in a descending position. In 9-month fetuses both uterine tubes were found to be in a horizontal position in twelve cases, in eight cases one of the uterine tubes was in the position close to a descending one. In fourteen fetuses 10 months of development one uterine tube was in a descending position, and only in six cases both uterine tubes were located horizontally. The length of the uterine tubes of 4-7-month fetuses deceased during 2017-2019 was not found to differ reliably. Similar regularity was found in the group of fetuses aged from 9 to 10 months. The length of the uterine tubes of the archival specimens increases reliably every two months. In this group of fetuses the parameters of the uterine tube length aged from 9 to 10 months were found to differ reliably contrary to the length of the uterine tubes in the group of modern specimens of a similar age. Comparison of dynamics in changes of the uterine tube length in the two groups of fetuses remote in time showed that within the frame of one group differences in the morphometric parameters between the right and left uterine tubes are not considerable. Therefore, the study of peculiarities in the structure of the uterine tubes at every stage of the perinatal period found certain peculiarities and regularities of their development.

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“…Mesonephric adenocarcinoma is a rare tumor, which is assumed to arise from mesonephric (Wolffian) remnants of the female genital tract. The remnants are usually located in the lateral wall of the cervix in which the majority of mesonephric adenocarcinomas occur but may also be found within the uterine corpus, vagina, and ovary [3,4]. Mesonephric adenocarcinoma of the uterine corpus is thus even rarer with only few cases reported in the literature [1,4].…”

mentioning

confidence: 99%

“…The remnants are usually located in the lateral wall of the cervix in which the majority of mesonephric adenocarcinomas occur but may also be found within the uterine corpus, vagina, and ovary [3,4]. Mesonephric adenocarcinoma of the uterine corpus is thus even rarer with only few cases reported in the literature [1,4]. They were typically found in the posterior or lateral myometrium of the uterine body [1,4], where mesonephric remnants are theoretically present.…”

mentioning

confidence: 99%

Mesonephric Adenocarcinoma of the Uterine Fundus Exhibiting High 18F-FDG Uptake

2020

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Mesonephric adenocarcinoma is a rare tumor that is considered to develop from mesonephric remnants of the female genital tract. This tumor usually occurs in the lateral wall of the uterine cervix. Herein, we present an exceptionally rare case of mesonephric adenocarcinoma located in the uterine fundus. The tumor exhibited intense hypermetabolism on 18F-FDG PET/CT. Based on the characteristic histologic features and immunohistochemical phenotypes, the diagnosis of mesonephric adenocarcinoma was confirmed. The patient underwent hysterectomy with bilateral salpingo-oophorectomy and pelvic lymph node dissection, and no lymph node or distant metastasis was identified. After 20 months of surveillance without adjuvant therapy, she remains free of relapse.

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Mesonephric adenocarcinoma of the uterine corpus with intracystic growth completely confined to the myometrium: a case report and literature review

Cited by 20 publications

References 14 publications

Mesonephric Adenocarcinoma Arising From The Uterine Corpus：Case Reports and Literature Review

Mesonephric Adenocarcinoma Arising From The Uterine Corpus：Case Reports and Literature Review

Characteristics of the uterine tubes in the fetal period: topographic and morphometric parallels

Mesonephric Adenocarcinoma of the Uterine Fundus Exhibiting High 18F-FDG Uptake

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