Mesonephric carcinoma of the uterine corpus: A report of two cases

Abstract

Abstract. Mesonephric carcinoma of the uterine corpus is an extremely rare malignancy that originates from the mesonephric remnant of the female reproductive tract. There have been no previous reports of mesonephric carcinoma accompanied by a sarcomatous component. The current study presents two cases of uterine corpus mesonephric carcinoma with sarcomatous components that occurred in postmenopausal women. Immunohistochemically, the tumour cells were positive for vimentin and CD10. The tumours of these patients were located in the uterine myometrium; therefore, treatment was similar to that for endometrial cancer. Although the follow-up period was short in the current cases, no metastatic disease was identified in the second case and thus, this may increase clinical knowledge with regard to the biological behavior of these rare malignancies.

Cytologic features of upper gynecologic tract adenocarcinomas exhibiting mesonephric‐like differentiation

“…Most commonly, these tumors arise in the lower gynecologic tract, particularly in the lateral cervix and vagina . Examples in the upper gynecologic tract, such as in the uterine corpus and ovary, are reported only rarely. Within this context, they have been referred to in the literature as “mesonephric‐like adenocarcinoma” because their association with mesonephric remnants has not been firmly established.…”

“…1,2 Examples in the upper gynecologic tract, such as in the uterine corpus and ovary, [3][4][5][6] are reported only rarely. Within this context, they have been referred to in the literature as "mesonephric-like adenocarcinoma" 3,6,7 because their association with mesonephric remnants has not been firmly established. However, similarities in their immunohistochemical and molecular signatures argue in favor of mesonephric differentiation.…”

1 / Clinicopathologic and molecular characteristics of mesonephric adenocarcinoma arising from the uterine body

“…Eleven cases of UB-MNAC have been reported to date (Table 1). [10][11][12][13][14][15][16][17][18] At the time of diagnosis, the FIGO stage was IB in 8, II in 1, III in 1, and IV in 1 patients. Six patients with FIGO stage I tumor received no additional therapy after surgery, whereas the remaining 2/8 patients received postoperative radiation therapy.…”

“…Although most cases of MNAC are found in the uterine cervix (UC), 2,8,9 several cases of MNAC arising from the ovaries, vagina, and uterine corpus have been reported. 5,[10][11][12][13][14][15][16][17][18][19] The pathogenesis of MNAC remains unknown. MNAC shows preserved phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression, wild-type p53 expression pattern, and nondiffuse p16 expression, indicating that this rare tumor exhibits immunohistochemical and molecular features different from those of endometrial endometrioid and serous carcinoma and usual-type endocervical adenocarcinoma.…”

“…Most publications on UB-MNAC are individual case reports. [10][11][12][13][14][15][16][17][18] Although some case series have described the clinicopathologic characteristics of MNAC, they dealt with only a few cases of UB-MNAC. 3,6,20,22 We recently identified some cases of UB-MNAC in postmenopausal women who developed distant metastases.…”