Mesoporous Aerogel Microparticles Injected into the Abdominal Cavity of Mice Accumulate in Parathymic Lymph Nodes

Király, Gábor; Egu, John Chinonso; Hargitai, Zoltán; Kovács, Ilona; Fábián, István; Kalmár, József; Szemán-Nagy, Gábor

doi:10.3390/ijms22189756

Cited by 6 publications

(5 citation statements)

References 41 publications

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“…Aerogels are an upcoming class of carriers for therapeutic drug delivery, having low density (0.005–0.50 g/cm 3 ), high specific surface area (300–1000 m 2 /g), and high porosity (upto 99%) [ 95 , 96 , 97 ]. Polymers such as starch, cellulose, pectin, ALG, etc., can be used to produce highly adsorption-efficient aerogel microparticles.…”

Section: Hydrogel Formation Methodsmentioning

confidence: 99%

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Abourehab

Singh

Pramanik

et al. 2022

IJMS

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Biopolymeric nanoparticulate systems hold favorable carrier properties for active delivery. The enhancement in the research interest in alginate formulations in biomedical and pharmaceutical research, owing to its biodegradable, biocompatible, and bioadhesive characteristics, reiterates its future use as an efficient drug delivery matrix. Alginates, obtained from natural sources, are the colloidal polysaccharide group, which are water-soluble, non-toxic, and non-irritant. These are linear copolymeric blocks of α-(1→4)-linked l-guluronic acid (G) and β-(1→4)-linked d-mannuronic acid (M) residues. Owing to the monosaccharide sequencing and the enzymatically governed reactions, alginates are well-known as an essential bio-polymer group for multifarious biomedical implementations. Additionally, alginate’s bio-adhesive property makes it significant in the pharmaceutical industry. Alginate has shown immense potential in wound healing and drug delivery applications to date because its gel-forming ability maintains the structural resemblance to the extracellular matrices in tissues and can be altered to perform numerous crucial functions. The initial section of this review will deliver a perception of the extraction source and alginate’s remarkable properties. Furthermore, we have aspired to discuss the current literature on alginate utilization as a biopolymeric carrier for drug delivery through numerous administration routes. Finally, the latest investigations on alginate composite utilization in wound healing are addressed.

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Section: Hydrogel Formation Methodsmentioning

confidence: 99%

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Abourehab

Singh

Pramanik

et al. 2022

IJMS

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“…Kiraly et al in their study injected a fluorescein-labeled silica-gelatin aerogel microparticles (FSGM) into the peritoneum of mice to assess acute toxicity. They reported no physiological abnormalities or disorder were discovered after a three-week-long experiment [ 81 ]. A nano-porous silica aerogel was developed for drug delivery for oral administration of paclitaxel (PTX), an anticancer drug.…”

Section: Biomedical Applications Of Aerogelmentioning

confidence: 99%

“…In addition, Kiraly et al generated a hybrid silica-gelatin aerogel by combining the sol–gel and co-gelation procedures. This mesoporous aerogel exhibited minimal toxicity after being infused in mice’s abdominal cavity and placed in parathymic lymph nodes as shown in Figure 6 [ 81 ].…”

Section: Biomedical Applications Of Aerogelmentioning

confidence: 99%

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Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

et al. 2023

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At present, aerogel is one of the most interesting materials globally. The network of aerogel consists of pores with nanometer widths, which leads to a variety of functional properties and broad applications. Aerogel is categorized as inorganic, organic, carbon, and biopolymers, and can be modified by the addition of advanced materials and nanofillers. Herein, this review critically discusses the basic preparation of aerogel from the sol–gel reaction with derivation and modification of a standard method to produce various aerogels for diverse functionalities. In addition, the biocompatibility of various types of aerogels were elaborated. Then, biomedical applications of aerogel were focused on this review as a drug delivery carrier, wound healing agent, antioxidant, anti-toxicity, bone regenerative, cartilage tissue activities and in dental fields. The clinical status of aerogel in the biomedical sector is shown to be similarly far from adequate. Moreover, due to their remarkable properties, aerogels are found to be preferably used as tissue scaffolds and drug delivery systems. The advanced studies in areas including self-healing, additive manufacturing (AM) technology, toxicity, and fluorescent-based aerogel are crucially important and are further addressed.

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“…Their main characteristics are high specific surface area (500–1200 m 2 g −1 ), high porosity (80–99.8%), low density (∼0.003–0.5 g cm −3 ), low thermal conductivity (0.005–0.1 W/mK), ultra-low dielectric constant ( k = 1.0–2.0) and low refraction index (∼1.05). Silica-based aerogels are biocompatible as shown by an ever-growing number of in vitro and in vivo studies [ 6 , 8 , 9 ]. This makes them promising candidates for enzyme immobilization supports, drug delivery vehicles and bone regeneration implants.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Aqueous Bovine Serum Albumin with Silica Aerogel Microparticles: Sorption Induced Aggregation

Forgács¹,

Ranga²,

Fábián³

et al. 2022

IJMS

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Mesoporous silica aerogels have a wide range of potential applications in biotechnology, the food industry, pharmacy and medicine. Understanding the nature of the interactions of biomolecules with these porous nanostructured materials is essential for achieving optimum performance in the targeted applications. In this study, the well-characterized bovine serum albumin (BSA) was chosen as a model protein to probe protein–aerogel interactions in the solution phase. Aqueous BSA was mixed with suspended silica aerogel microparticles, and the colloid system was monitored on-line by UV–vis spectrophotometry and turbidimetry. The global mathematical analysis of the time-resolved data reveals that the fast sorption of the protein on the aerogel microparticles follows a multistep binding mechanism. The extensive sorption of the protein eventually induces the aggregation of the covered aerogel due to the alteration of the electrical double layer of the particles. The interaction of BSA and silica aerogel is the strongest between pH = 4 and 5, because their native surface charges are the opposite in this pH range, as indicated by their respective zeta potentials.

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Mesoporous Aerogel Microparticles Injected into the Abdominal Cavity of Mice Accumulate in Parathymic Lymph Nodes

Cited by 6 publications

References 41 publications

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

Interaction of Aqueous Bovine Serum Albumin with Silica Aerogel Microparticles: Sorption Induced Aggregation

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