Mesoporous Bioactive Nanoparticles for Bone Tissue Applications

Arcos, Daniel; Portolés, María Teresa

doi:10.3390/ijms24043249

Cited by 13 publications

(6 citation statements)

References 153 publications

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“…Based on the amount of Ca, Si, P, and Li ions released, Li-MNPs are expected to influence the cellular regenerative response, as these ions have been shown to significantly stimulate stem cell and endothelial cell functions. 37 Therefore, the biological effects of Li-MNPs were investigated using hDPSCs, resident cells on the dental pulp susceptible to bacterial infection, which play an important role in tissue regeneration. 38,39 We first identified these cells using flow cytometry and immunofluorescence.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional Lithium-Doped Mesoporous Nanoparticles for Effective Dentin Regeneration in vivo

Liang,

Chen,

Jiang

et al. 2023

IJN

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Introduction:Effective infection control without irritating the pulp tissue is the key to successful vital pulp therapy. Developing a novel antibacterial biomaterial that promotes dentin regeneration for pulp capping is thus a promising strategy for enhancing vital pulp therapy. Methods: Lithium-doped mesoporous nanoparticles (Li-MNPs) were synthesized using an alkali-catalyzed sol-gel method. The particle size, elemental distribution, surface morphology, pore structure, and ion release from Li-MNPs were measured. Human dental pulp stem cells (hDPSCs) and Streptococcus mutans (S. mutans) were used to evaluate the biological effects of Li-MNPs. In addition, a dental pulp exposure mouse model was used to evaluate the regenerative effects of Li-MNPs. Results: Li-MNPs had a larger surface area (221.18 m 2 /g), a larger pore volume (0.25 cm 3 /g), and a smaller particle size (520.92 ± 35.21 nm) than MNPs. The in vitro investigation demonstrated that Li-MNPs greatly enhanced the biomineralization and odontogenic differentiation of hDPSCs through the Wnt/β-catenin signaling pathway. Li-MNPs showed a strong antibacterial effect on S. mutans. As expected, Li-MNPs significantly promoted dentin regeneration in situ and in vivo. Conclusion: Li-MNPs promoted dentin regeneration and inhibited S. mutans growth, implying a possible application as a pulp capping agent in vital pulp therapy.

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Section: Resultsmentioning

confidence: 99%

Multifunctional Lithium-Doped Mesoporous Nanoparticles for Effective Dentin Regeneration in vivo

Liang,

Chen,

Jiang

et al. 2023

IJN

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“…[33] We selected the gel-sol method to synthesize MBG nanoparticles due to their good bone regeneration and integration properties. [34][35][36] Both TEM images and scanning electron microscopy (SEM) images showed uniform and highly ordered mesoporous spheres with a particle size of ≈500 nm (Figure 1B,C). The X-ray diffraction pattern exhibited a broad peak at 24°, indicative of the amorphous structure of MBG (Figure S1C, Supporting Information).…”

Section: Design and Construction Of Smb6 Biomimetic Bi-layer Cranium-...mentioning

confidence: 99%

A Novel 3D‐Printed Bi‐Layer Cranial‐Brain Patch Promotes Brain Injury Repair and Bone Tissue Regeneration

Zhou,

Liu,

Zhang

et al. 2024

Adv Funct Materials

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Traumatic brain injury (TBI), recognized as the world's most serious public health problem, currently lacks effective treatment options. The development of the patch has great clinical significance whether it is used as a skull implant material or TBI repair. In response to this critical health challenge, a novel 3D‐printed bi‐layer cranial‐brain patch (SMB6) with dual functionality, addressing both TBI repair and skull regeneration, is developed. In the first layer, the incorporation of high concentrations of mesoporous bioactive glass nanoparticles establishes a microenvironment for bone regeneration. Meanwhile, the second layer, comprised of methacrylated silk fibroin hydrogel, provides essential mechanical support for nanocell membrane vesicles loaded with macrophage colony‐stimulating factor and interleukin‐6. This innovative design aims to interrupt the cascade of secondary brain injury. In experimental models of TBI, SMB6 demonstrates remarkable efficacy in inhibiting brain edema, exerting therapeutic effects on blood vessels, nerves, and inflammation. Additionally, promising outcomes are observed in promoting bone regeneration in skull defect models. This work not only introduces a potential therapeutic patch for TBI‐related diseases but also provides novel insights for the clinical translation of cranial patches.

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“…Thus, it is essential to create an effective drug delivery system that can sustain stable and suitable concentrations of quercetin in targeted tissues for clinical use. Recently, MBG nanoparticles are being considered as potential drug carriers for bone defect sites, due to their high porosity, specific surface area, and strong ability to stimulate bone tissue regeneration [ 21 ]. Furthermore, researches indicated that when MBG was utilized as a drug delivery system for bone repair, it did not elicit an unfavorable immune response in macrophages [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway

Yang,

Hu,

Zhao

et al. 2024

J Nanobiotechnol

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Background Impaired osteo-/angiogenesis, excessive inflammation, and imbalance of the osteoimmune homeostasis are involved in the pathogenesis of the alveolar bone defect caused by periodontitis. Unfortunately, there is still a lack of ideal therapeutic strategies for periodontitis that can regenerate the alveolar bone while remodeling the osteoimmune microenvironment. Quercetin, as a monomeric flavonoid, has multiple pharmacological activities, such as pro-regenerative, anti-inflammatory, and immunomodulatory effects. Despite its vast spectrum of pharmacological activities, quercetin’s clinical application is limited due to its poor water solubility and low bioavailability. Results In this study, we fabricated a quercetin-loaded mesoporous bioactive glass (Quercetin/MBG) nano-delivery system with the function of continuously releasing quercetin, which could better promote the bone regeneration and regulate the immune microenvironment in the alveolar bone defect with periodontitis compared to pure MBG treatment. In particular, this nano-delivery system effectively decreased injection frequency of quercetin while yielding favorable therapeutic results. In view of the above excellent therapeutic effects achieved by the sustained release of quercetin, we further investigated its therapeutic mechanisms. Our findings indicated that under the periodontitis microenvironment, the intervention of quercetin could restore the osteo-/angiogenic capacity of periodontal ligament stem cells (PDLSCs), induce immune regulation of macrophages and exert an osteoimmunomodulatory effect. Furthermore, we also found that the above osteoimmunomodulatory effects of quercetin via macrophages could be partially blocked by the overexpression of a key microRNA——miR-21a-5p, which worked through inhibiting the expression of PDCD4 and activating the NF-κB signaling pathway. Conclusion In summary, our study shows that quercetin-loaded mesoporous nano-delivery system has the potential to be a therapeutic approach for reconstructing alveolar bone defects in periodontitis. Furthermore, it also offers a new perspective for treating alveolar bone defects in periodontitis by inhibiting the expression of miR-21a-5p in macrophages and thereby creating a favorable osteoimmune microenvironment. Graphical Abstract

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Mesoporous Bioactive Nanoparticles for Bone Tissue Applications

Cited by 13 publications

References 153 publications

Multifunctional Lithium-Doped Mesoporous Nanoparticles for Effective Dentin Regeneration in vivo

Multifunctional Lithium-Doped Mesoporous Nanoparticles for Effective Dentin Regeneration in vivo

A Novel 3D‐Printed Bi‐Layer Cranial‐Brain Patch Promotes Brain Injury Repair and Bone Tissue Regeneration

Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway

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