Mesoporous materials and technologies for development of oral medicine

Shen, Shoucang; Dong, Youming; Letchmanan, Kumaran; Ng, Wai Kiong

doi:10.1016/b978-0-323-47720-8.00024-9

Cited by 7 publications

(4 citation statements)

References 288 publications

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“…Mesoporous materials, e.g., mesoporous silica, a subclass of solid dispersion systems, are considered highly effective for drug amorphisation due to their ability to achieve the spatial confinement of drug molecules within their nanometre-scale pore structure [4]. Shen et al [5] suggested that drugs would exist in an amorphous state within the mesoporous silica if the pore size were smaller than 12 times the drug’s molecular size. Mesoporous carriers also offer formulation flexibility due to tunable pore size and surface area [6].…”

Section: Introductionmentioning

confidence: 99%

“…In general, solvent-based loading techniques, especially spray drying, produce drug-loaded mesoporous silica with a high loading efficiency compared to solvent-free techniques [6]. However, higher drug loadings above 30% ( w / w ) could lead to incomplete amorphisation, i.e., a small amount of crystalline drug will remain on the exterior surface of the generated particles [5]. Drug molecules can theoretically adsorb onto the silica surface of mesopores as a monolayer or multilayers, depending on the drug’s molecular dimension, accessible surface area, and pore size [8].…”

Section: Introductionmentioning

confidence: 99%

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Delivery of Poorly Soluble Drugs via Mesoporous Silica: Impact of Drug Overloading on Release and Thermal Profiles

Elyafi

Mohammed

et al. 2019

Pharmaceutics

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Among the many methods available for solubility enhancement, mesoporous carriers are generating significant industrial interest. Owing to the spatial confinement of drug molecules within the mesopore network, low solubility crystalline drugs can be converted into their amorphous counterparts, which exhibit higher solubility. This work aims to understand the impact of drug overloading, i.e., above theoretical monolayer surface coverage, within mesoporous silica on the release behaviour and the thermal properties of loaded drugs. The study also looks at the inclusion of hypromellose acetate succinate (HPMCAS) to improve amorphisation. Various techniques including DSC, TGA, SEM, assay and dissolution were employed to investigate critical formulation factors of drug-loaded mesoporous silica prepared at drug loads of 100–300% of monolayer surface coverage, i.e., monolayer, double layer and triple layer coverage. A significant improvement in the dissolution of both Felodipine and Furosemide was obtained (96.4% and 96.2%, respectively). However, incomplete drug release was also observed at low drug load in both drugs, possibly due to a reversible adsorption to mesoporous silica. The addition of a polymeric precipitation inhibitor HPMCAS to mesoporous silica did not promote amorphisation. In fact, a partial coating of HPMCAS was observed on the exterior surface of mesoporous silica particles, which resulted in slower release for both drugs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Delivery of Poorly Soluble Drugs via Mesoporous Silica: Impact of Drug Overloading on Release and Thermal Profiles

Elyafi

Mohammed

et al. 2019

Pharmaceutics

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“…Silica nanoparticles are absorbent and abrasive in their impermeable form, whereas mesoporous silica nanoparticles (MSNPs) have applications in nano drug delivery [ 149 , 152 ]. In this respect, MSNPs with a dimension of less than 500 nm have remarkable capabilities for multiple drug delivery applications [ 153 ]. MSNPs are a hollow nanocapsular framework that allows drug molecules to be conjugated via open functional groups [ 154 ].…”

Section: Silica-based Nanoparticulate Drug Delivery Systemmentioning

confidence: 99%

Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy

et al. 2022

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Research into the application of nanocarriers in the delivery of cancer-fighting drugs has been a promising research area for decades. On the other hand, their cytotoxic effects on cells, low uptake efficiency, and therapeutic resistance have limited their therapeutic use. However, the urgency of pressing healthcare needs has resulted in the functionalization of nanoparticles’ (NPs) physicochemical properties to improve clinical outcomes of new, old, and repurposed drugs. This article reviews recent research on methods for targeting functionalized nanoparticles to the tumor microenvironment (TME). Additionally, the use of relevant engineering techniques for surface functionalization of nanocarriers (liposomes, dendrimers, and mesoporous silica) and their critical roles in overcoming the current limitations in cancer therapy—targeting ligands used for targeted delivery, stimuli strategies, and multifunctional nanoparticles—were all reviewed. The limitations and future perspectives of functionalized nanoparticles were also finally discussed. Using relevant keywords, published scientific literature from all credible sources was retrieved. A quick search of the literature yielded almost 400 publications. The subject matter of this review was addressed adequately using an inclusion/exclusion criterion. The content of this review provides a reasonable basis for further studies to fully exploit the potential of these nanoparticles in cancer therapy.

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“…One approach that has gained increased interest during the recent decade due to the development in nanotechnology is to formulate amorphous APIs in mesoporous materials [ 6 , 7 , 8 ]. Amorphous substances generally have higher apparent solubility values compared to their crystalline counterparts and can therefore be used in order to obtain a desired therapeutic effect.…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate—An In Vivo Evaluation

Torre

Lindmark²,

Cheung

et al. 2022

Molecules

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An attractive approach to increase the aqueous apparent solubility of poorly soluble drugs is to formulate them in their amorphous state. In the present study, celecoxib, a poorly soluble drug, was successfully loaded into mesoporous magnesium carbonate (MMC) in its amorphous state via a solvent evaporation method. Crystallization of celecoxib was suppressed, and no reaction with the carrier was detected. The MMC formulation was evaluated in vitro and in vivo in terms of oral bioavailability. Celebra®, a commercially available formulation, was used as a reference. The two celecoxib formulations were orally administrated in male rats (average of n = 6 animals per group), and blood samples for plasma were taken from all animals at different time points after administration. There was no statistical difference (p > 0.05) in AUCinf between the two formulations. The results showed that MMC may be a promising drug delivery excipient for increasing the bioavailability of compounds with solubility-limited absorption.

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Mesoporous materials and technologies for development of oral medicine

Cited by 7 publications

References 288 publications

Delivery of Poorly Soluble Drugs via Mesoporous Silica: Impact of Drug Overloading on Release and Thermal Profiles

Delivery of Poorly Soluble Drugs via Mesoporous Silica: Impact of Drug Overloading on Release and Thermal Profiles

Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy

Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate—An In Vivo Evaluation

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