Mesoporous platinum nanoparticle-based nanoplatforms for combined chemo-photothermal breast cancer therapy

Fu, Bei; Dang, Meng; Tao, Jun; Li, Yanjun; Tang, Yuxia

doi:10.1016/j.jcis.2020.02.051

Cited by 60 publications

(34 citation statements)

References 40 publications

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“…Platinum nanoparticles have been widely used in clinical applications due to their excellent catalytic performance [68], imaging ability [69], excellent photothermal conversion ability, and radiosensitization ability [70]. Fu et al [71] performed lowmagnification (Figure 4(a)) and high-magnification SEM imaging (Figure 4(b)) and TEM imaging (Figure 4(c)) on mesoporous platinum nanoparticles. e structure of platinum nanoparticles and indications in the treatment of tumors are shown in Table 2.…”

Section: Platinum Nanoparticlesmentioning

confidence: 99%

Recent Advances in the Development of Noble Metal NPs for Cancer Therapy

Zhao

Xiang

Wang

et al. 2022

Bioinorganic Chemistry and Applications

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With the development of nanotechnology, noble metal nanoparticles are widely used in the treatment of cancer due to their unique optical properties, excellent biocompatibility, surface effects, and small size effects. In recent years, researchers have designed and synthesized a large number of nanomedicines that can be used for cancer treatment based on the morphology, physical and chemical properties, mechanism of action, and toxicological studies of noble metal nanoparticles. Furthermore, the integration of diagnosis and treatment, hyperthermia, cytotoxicity research, and drug delivery system based on the study of noble metal nanoparticles can be used as effective means for cancer treatment. This article focuses on the analysis of noble metal nanoparticles that are widely used in the treatment of cancer, such as gold nanoparticles, silver nanoparticles, platinum nanoparticles, and palladium nanoparticles. The various methods and mechanisms of action of noble metal nanoparticles in the treatment of cancer are objectively summarized in detail. Based on the research on the therapeutic safety and toxicity of noble metal nanoparticles, the development prospect of noble metal nanoparticles in the future clinical application is prospected.

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Section: Platinum Nanoparticlesmentioning

confidence: 99%

Recent Advances in the Development of Noble Metal NPs for Cancer Therapy

Zhao

Xiang

Wang

et al. 2022

Bioinorganic Chemistry and Applications

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“…Like RuNPs, Pt-based nanoparticles (PtNPs) are also used in cancer diagnosis, drug delivery, treatment and can induce PTT-mediated apoptosis [ 193 , 194 , 195 , 196 , 197 ]. For example, Pt-based nanostructure, DPMNPs, was synthesized via coating dichloro(1,2-diaminocyclohexane)platinum(II) with poly[2-( N , N -dimethylamino)ethyl methacrylate]-poly(ε-caprolactone).…”

Section: Ru-nanocomplexes In Crc Theranosticsmentioning

confidence: 99%

Ruthenium Complexes: An Alternative to Platinum Drugs in Colorectal Cancer Treatment

et al. 2021

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Colorectal cancer (CRC) is one of the intimidating causes of death around the world. CRC originated from mutations of tumor suppressor genes, proto-oncogenes and DNA repair genes. Though platinum (Pt)-based anticancer drugs have been widely used in the treatment of cancer, their toxicity and CRC cells’ resistance to Pt drugs has piqued interest in the search for alternative metal-based drugs. Ruthenium (Ru)-based compounds displayed promising anticancer activity due to their unique chemical properties. Ru-complexes are reported to exert their anticancer activities in CRC cells by regulating different cell signaling pathways that are either directly or indirectly associated with cell growth, division, proliferation, and migration. Additionally, some Ru-based drug candidates showed higher potency compared to commercially available Pt-based anticancer drugs in CRC cell line models. Meanwhile Ru nanoparticles coupled with photosensitizers or anticancer agents have also shown theranostic potential towards CRC. Ru-nanoformulations improve drug efficacy, targeted drug delivery, immune activation, and biocompatibility, and therefore may be capable of overcoming some of the existing chemotherapeutic limitations. Among the potential Ru-based compounds, only Ru (III)-based drug NKP-1339 has undergone phase-Ib clinical trials in CRC treatment.

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“…This phenomenon is usually achieved through EPR in passive tumor targeting. Based on this effect, both macromolecular drugs and NPs can target BC more powerfully as compared to small-molecule drugs [88,89]. The clearance of the drug with NPs normally occurs through various organs such as the liver, kidneys, lungs, spleen, as well as the complement and immune systems.…”

Section: In Vivo Ddsmentioning

confidence: 99%

Targeting Engineered Nanoparticles for Breast Cancer Therapy

et al. 2021

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Breast cancer (BC) is the second most common cancer in women globally after lung cancer. Presently, the most important approach for BC treatment consists of surgery, followed by radiotherapy and chemotherapy. The latter therapeutic methods are often unsuccessful in the treatment of BC because of their various side effects and the damage incurred to healthy tissues and organs. Currently, numerous nanoparticles (NPs) have been identified and synthesized to selectively target BC cells without causing any impairments to the adjacent normal tissues or organs. Based on an exploratory study, this comprehensive review aims to provide information on engineered NPs and their payloads as promising tools in the treatment of BC. Therapeutic drugs or natural bioactive compounds generally incorporate engineered NPs of ideal sizes and shapes to enhance their solubility, circulatory half-life, and biodistribution, while reducing their side effects and immunogenicity. Furthermore, ligands such as peptides, antibodies, and nucleic acids on the surface of NPs precisely target BC cells. Studies on the synthesis of engineered NPs and their impact on BC were obtained from PubMed, Science Direct, and Google Scholar. This review provides insights on the importance of engineered NPs and their methodology for validation as a next-generation platform with preventive and therapeutic effects against BC.

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Mesoporous platinum nanoparticle-based nanoplatforms for combined chemo-photothermal breast cancer therapy

Cited by 60 publications

References 40 publications

Recent Advances in the Development of Noble Metal NPs for Cancer Therapy

Recent Advances in the Development of Noble Metal NPs for Cancer Therapy

Ruthenium Complexes: An Alternative to Platinum Drugs in Colorectal Cancer Treatment

Targeting Engineered Nanoparticles for Breast Cancer Therapy

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