Mesoporous polydopamine carrying sorafenib and SPIO nanoparticles for MRI-guided ferroptosis cancer therapy

Guan, Qingqing; Guo, Ruomi; Huang, Siqi; Fan, Zhengqiu; Liu, Jie; Wang, Zhiyong; Yang, Xi; Shuai, Xintao; Cao, Zhong

doi:10.1016/j.jconrel.2020.01.048

Cited by 131 publications

(90 citation statements)

References 37 publications

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“…Considering other MRI contrast agents, iron-oxide based materials are commonly used to shorten T 2 relaxation time, leading to a negative contrast [124]. A theranostic system based on superparamagnetic iron oxide (SPIO) and melanin was developed by Guan et al who loaded mesoporous polydopamine nanoparticles (MPDA NPs) with ultra-small SPIO NPs and a drug (sorafenib, SRF), by means of π-π stacking and/or hydrophobic interaction [125]. The advantage of these novel design was that NIR irradiation of SPIO-SRF and melanin could be exploited to induced ferroptosis and PTT respectively, while, simultaneously, SPIO NP could act as negative contrast agent for MRI, shortening T 2 relaxation time.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

“…Since 2017, Xing et al showed that PDA could be efficiently used in PTT-CT in order to fight multiple drugs resistance (MDR) cancer cells [198]. More recently, Guan et al developed a potent anticancer nanodrug by using mesoporous PDA NP for delivery of sorafenib (SRF, clinically-approved drug) and superparamagnetic iron oxide (SPIO) NP in order to induce ferroptosis of tumor cells [125]. Ferroptosis is an iron-dependent type of programmed cell death characterized by the accumulation of peroxides.…”

Section: Ptt-chemotherapymentioning

confidence: 99%

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Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin-based nanoparticles (MNP), including polydopamine nanoparticles (PDA NP), excel for their extraordinary combination of additional optical, electronic, chemical, photophysical, and photochemical properties. Thanks to these features, melanin plays an important multifunctional role in the design of new platforms for nanomedicine where this material works not only as a mechanical support or scaffold, but as an active component for imaging, even multimodal, and simple or synergistic therapy. The number of examples of bio-applications of MNP increased dramatically in the last decade. Here, we review the most recent ones, focusing on the multiplicity of functions that melanin performs in theranostics platforms with increasing complexity. For the sake of clarity, we start analyzing briefly the main properties of melanin and its derivative as well as main natural sources and synthetic methods, moving to imaging application from mono-modal (fluorescence, photoacoustic, and magnetic resonance) to multi-modal, and then to mono-therapy (drug delivery, anti-oxidant, photothermal, and photodynamic), and finally to theranostics and synergistic therapies, including gene- and immuno- in combination to photothermal and photodynamic. Nanomedicine aims not only at the treatment of diseases, but also to their prevention, and melanin in nature performs a protective action, in the form of nanopigment, against UV-Vis radiations and oxidants. With these functions being at the border between nanomedicine and cosmetics nanotechnology, recently examples of applications of artificial MNP in cosmetics are increasing, paving the road to the birth of the new science of nanocosmetics. In the last part of this review, we summarize and discuss these important recent results that establish evidence of the interconnection between nanomedicine and cosmetics nanotechnology.

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Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Section: Ptt-chemotherapymentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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“…Nevertheless, in this model, the presence of IONs allowed them to trigger an additional photothermal effect (PTE). [ 40 ] The resulting multitherapeutic nanosystem was able to induce complete tumor destruction in vivo (HCT116) when the three killing effects were combined.…”

Section: Intracellular Chemodynamic Therapy: Ferroptosismentioning

confidence: 99%

Emerging Strategies in Anticancer Combination Therapy Employing Silica‐Based Nanosystems

Castillo

2020

Biotechnology Journal

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Combination therapy has emerged as one of the most promising approaches for cancer treatment. However, beyond remotely‐triggered therapies that require advanced infrastructures and optimization, new combination therapies based on internally triggered cell‐killing effects have also demonstrated promising therapeutic profiles. In this revision, the focus is on self‐triggered strategies able to improve the therapeutic effect of drug delivery nanosystems. As reviewed, ferroptosis, hypoxia, and immunotherapy show potency enough to treat satisfactorily tumors in vivo. However, the interest of combining those with chemotherapeutics, especially with carriers based on mesoporous silica, has provided a new generation of therapeutic nanomedicines with potential enough to achieve complete tumor remission in murine models.

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“…Guan Q et al (2020) investigated mesoporous polydopamine carrying sorafenib and. Superparamagnetic iron oxide nanoparticles (SPION) for ferroptosis cancer therapy 36 . The heat generated due to laser irradiation of these particles offered a ferroptosis effect due to an increase in temperature.…”

Section: Superparamagnetic Npsmentioning

confidence: 99%

Exploring Recent Advances in Nanotherapeutics

Rao¹,

Sonawane²,

Sapate³

et al. 2020

J. Drug Delivery Ther.

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Nanotechnology is a rapidly expanding field, encompassing the development of materials in a size range of 5-200 nanometers (nm). The applications of nanotechnology to drug delivery opened the floodgates to create novel therapeutics and diagnostics which have changed the landscape of pharmaceutical and biotechnological industries. Advances in nanotechnology are being utilized in medicine for therapeutic drug delivery and treatment of various diseases and disorders. The biodegradable nanoparticle/nanocarriers, in which drug is dissolved and entrapped are specially designed to absorb the drug and to protect it against chemical and enzymatic degradation. The important role to design these nanostructures as a delivery system is to release pharmacologically active molecules for site-specific action with an accurate dose. In recent times, several biodegradable polymeric nanostructures have been developed with an innate capacity to target specific organs/tissue to deliver the drug. Nanoparticulate drug delivery systems use polymers or lipids as carriers for drugs. Newer polymers engineered to achieve temporal and spatial drug delivery form the mainstay of these systems. In nanotechnology, being tiny molecules of immunotherapeutic have many advantages over biological drugs regarding complexity, tissue penetration, manufacturing cost, stability and shelf life, which is one of dominating therapy in the current research field. The present review gives details about the recent developments of nanostructure drug delivery systems and their applications. Keywords: liposomes, polymeric micelles, gold nanoparticles, superparamagnetic nanoparticles, solid lipid nanoparticles, aptamers, quantum dots.

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Mesoporous polydopamine carrying sorafenib and SPIO nanoparticles for MRI-guided ferroptosis cancer therapy

Cited by 131 publications

References 37 publications

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Emerging Strategies in Anticancer Combination Therapy Employing Silica‐Based Nanosystems

Exploring Recent Advances in Nanotherapeutics

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