2020
DOI: 10.1002/slct.202002071
|View full text |Cite
|
Sign up to set email alerts
|

Mesoporous Si‐MCM‐41/Polymer as a pH‐Responsive Drug Delivery System for Cancer Therapy

Abstract: Nano-controlled drug delivery systems such as polymer nanocomposites introduce new strategies for the cancer prevention, diagnosis and treatment. In this study, we designed a biocompatible polymer Nanocomposites (NCs) based on modified mobil composition of matter No. 41 (MCM-41) nanoparticles (MCM-41-NH 2) and copolymer grafted chitosan by acrylamide and acrylic acid (CS-graft-poly (AAm-co-AA) as a pHsensitive polymer, and employed for targeted anticancer drug delivery. Doxorubicin (DOX) is a potent drug for c… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
6
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 10 publications
(6 citation statements)
references
References 31 publications
0
6
0
Order By: Relevance
“…At pH 4.0 (Figures 7b and 8B), all of the investigated nanocarriers exhibited increased release of Dox, which was expected due to its known better solubility in acidic media [54,55]. Such acidic conditions are expected for tumour cells because of their extensive metabolism [56]. The pristine MCM-41 loaded with Dox at pH = 4.0 showed a significant release with some burst effect in the first 6 h of dissolution (47.3 ±.…”
Section: Drug Releasementioning
confidence: 80%
“…At pH 4.0 (Figures 7b and 8B), all of the investigated nanocarriers exhibited increased release of Dox, which was expected due to its known better solubility in acidic media [54,55]. Such acidic conditions are expected for tumour cells because of their extensive metabolism [56]. The pristine MCM-41 loaded with Dox at pH = 4.0 showed a significant release with some burst effect in the first 6 h of dissolution (47.3 ±.…”
Section: Drug Releasementioning
confidence: 80%
“…Since our systems are intended to be used for peroral administration, we performed dissolution studies in standard media with pH 1.2 and 6.8. A medium with pH 5 was chosen to simulate the environmental conditions in tumor cells (see Table 3 ) [ 62 ].…”
Section: Resultsmentioning
confidence: 99%
“…Since our systems are intended to be used for peroral administration, we performed dissolution studies in standard media with pH 1.2 and 6.8. A medium with pH 5 was chosen to simulate the environmental conditions in tumor cells (see Table 3) [62]. As a cationic drug (pKa = 8.3), DOX release from all the samples was faster into media with pH 1.2 and pH 5.0 (lower T 50 values) compared to pH 6.8 [62,63].…”
Section: In Vitro Drug Releasementioning
confidence: 99%
“…At pH 4.0 ( Figure 7 b and Figure 8 B), all of the investigated nanocarriers exhibited increased release of Dox, which was expected due to its known better solubility in acidic media [ 54 , 55 ]. Such acidic conditions are expected for tumour cells because of their extensive metabolism [ 56 ]. The pristine MCM-41 loaded with Dox at pH = 4.0 showed a significant release with some burst effect in the first 6 h of dissolution (47.3 ±.…”
Section: Resultsmentioning
confidence: 99%