Mesoporous silica-coated gold nanorods loaded with tetrazolyl phthalocyanine as NIR light-activated nano-switches for synergistic photothermal and photodynamic inactivation of antibiotic-resistant Escherichia coli

Abstract

A light-controlled nano-switch was prepared by assembling the mesoporous silica-coated gold nanorods with bis-(1-(4-hydroxyphenyl)-5-mercapto-tetrazolyl) silicon (IV) phthalocyanines, which exhibited excellent triple functions with control release of phthalocyanines and generation of...

Glutathione-Sensitive Mesoporous Organosilica-Coated Gold Nanorods as Drug Delivery System for Photothermal Therapy-Enhanced Precise Chemotherapy

“…However, as a novel theranostic platform, GNR bears two disadvantages: low specific surface area impending the drug loading and the clustering and aggregating properties within cells (Gui and Cui 2012;Hou, et al, 2019). To solve the limitations mentioned earlier, GNR with mesoporous silica coating was developed as a multifunctional theranostic system (Zhang, et al, 2012;Chen, et al, 2015;Ye, et al, 2021). The GNR core functions as the hyperthermia agent and releases heat for inhibiting cancer cell DNA repair (Pan, et al, 2017).…”