Mesoporous silica coated SPIONs containing curcumin and silymarin intended for breast cancer therapy

Sadegha, Soosan; Varshochian, Reyhaneh; Dadras, Pegah; Hosseinzadeh, Hosniyeh; Sakhtianchi, Ramin; Mirzaie, Zahra; Shafiee, Akram; Atyabi, Fatemeh; Dinarvand, Rassoul

doi:10.1007/s40199-022-00453-9

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…The study of Sadegha et al aimed to investigate the potential use of super-paramagnetic iron oxide nanoparticles (SPIONs), coated with mesoporous silica (mSiO 2 ) and loaded with curcumin (CUR) and silymarin (SIL), as a theranostic asset for breast cancer treatment (Figure 11) [11]. SPIONs were synthesized via a reverse microemulsion method.…”

Section: Iron Oxide-based Nanoparticlesmentioning

confidence: 99%

“…• Several types of polymers, e.g., PLGA, PEG, PCL, CMC, and PVP, as well as mesoporous silica, were used for surface functionalization of iron oxide-based nanoparticles, which increased the stability of flavonoid-nanoparticle conjugates and impacted the controlled release of organic molecules. Iron oxide nanoparticles have been produced and formulated with flavonoids for applications in the treatment of ovarian cancer [75] after coating with mesoporous silica [11] or in the form of nanocomposite of Fe 2 O 3 , CHI, and montmorillonite (MMT) in breast cancer [74]. Methoxy poly(ethylene glycol) (mPEG)-b-PLGA-coated iron oxide nanoparticles seem to be suitable carriers of flavonoid compounds in the treatment of prostate cancer [76], whereas iron oxide NPs can serve as carriers of PLGA-encapsulated silibinin for sustained release in kidney cancer cells [77].…”

Section: To Sum Up Prosmentioning

confidence: 99%

“…Metal nanoparticles are becoming more and more widely considered as perspective pharmaceutical carriers because of their numerous advantages. Metal nanoparticles have been developed as a superior alternative to conventional cancer therapy treatment due to theranostic properties that provide both diagnosis and drug delivery designed to monitor the therapy [11]. Noble metal NPs enable the tracking of nano-complex therapeutic carriers within the body owing to their unique plasmonic properties, which makes such therapy more efficient and safer.…”

Section: Introductionmentioning

confidence: 99%

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Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine

Sysak

Czarczyńska-Goślińska

Szyk

et al. 2023

Nanomaterials

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Flavonoids are polyphenolic compounds widely occurring throughout the plant kingdom. They are biologically active and have many medical applications. Flavonoids reveal chemopreventive, anticarcinogenic, and antioxidant properties, as well as being able to modulate the immune system response and inhibit inflammation, angiogenesis, and metastasis. Polyphenols are also believed to reverse multidrug resistance via various mechanisms, induce apoptosis, and activate cell death signals in tumor cells by modulating cell signaling pathways. The main limitation to the broader usage of flavonoids is their low solubility, poor absorption, and rapid metabolism. To tackle this, the combining of flavonoids with nanocarriers could improve their bioavailability and create systems of wider functionalities. Recently, interest in hybrid materials based on combinations of metal nanoparticles with flavonoids has increased due to their unique physicochemical and biological properties, including improved selectivity toward target sites. In addition, flavonoids have further utilities, even in the initial step of preparation of metal nanomaterials. The review offers knowledge on multiple possibilities of the synthesis of flavonoid-metal nanoparticle conjugates, as well as presents some of their features such as size, shape, surface charge, and stability. The flavonoid-metal nanoparticles are also discussed regarding their biological properties and potential medical applications.

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Section: Iron Oxide-based Nanoparticlesmentioning

confidence: 99%

Section: To Sum Up Prosmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine

Sysak

Czarczyńska-Goślińska

Szyk

et al. 2023

Nanomaterials

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“…Cells have a higher uptake rate of nano-drugs with smaller particle sizes, thereby increasing their therapeutic effect. 17 Previous studies have also found that the efficacy of nano-drugs is better than that of ordinary drugs.…”

Section: Introductionmentioning

confidence: 99%

Nano Parthenolide Improves Intestinal Barrier Function of Sepsis by Inhibiting Apoptosis and ROS via 5-HTR2A

Guo¹,

She²,

Tan³

et al. 2023

IJN

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Background Intestinal barrier dysfunction is an important complication of sepsis, while the treatment is limited. Recently, parthenolide (PTL) has attracted much attention as a strategy of sepsis, but whether nano parthenolide (Nano PTL) is therapeutic in sepsis-induced intestinal barrier dysfunction is obscured. Methods In this study, cecal ligation and puncture (CLP)-induced sepsis rats and lipopolysaccharide (LPS)-stimulated intestinal epithelial cells (IECs) were used to investigate the effect of PTL on intestinal barrier dysfunction. Meanwhile, we synthesized Nano PTL and compared the protective effect of Nano PTL with ordinary PTL on intestinal barrier function in septic rats and IECs. Network pharmacology and serotonin 2A (5-HTR2A) inhibitor were used to explore the mechanism of PTL on the intestinal barrier function of sepsis. Results The encapsulation rate of Nano PTL was 95±1.5%, the drug loading rate was 11±0.5%, and the average uptake rate of intestinal epithelial cells was 94%. Ordinary PTL and Nano PTL improved the survival rate and survival time of septic rats, reduced the mean arterial pressure and the serum level of inflammatory cytokines, and protected the liver and kidney functions in vivo, and increased the value of transmembrane resistance (TEER) reduced the reactive oxygen species (ROS) and apoptosis in IECs in vitro through 5-HTR2A. Nano PTL had better effect than ordinary PTL. Conclusion Ordinary PTL and Nano PTL can protect the intestinal barrier function of septic rats by inhibiting apoptosis and ROS through up-regulating 5-HTR2A, Nano PTL is better than ordinary PTL.

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“…Some therapeutic herbs derived from plants have recently garnered considerable interest owing to their broad spectrum of pharmacological effects (1,2). The therapeutic effects of herbs, nutritional supplements, and medicinal plants were evaluated for various diseases and chemo-preventive impact on cancer (3). The decreased risk of diseases and toxic effects related to their consumption at high concentrations implies that defined amounts of bioactive components derived from these sources exert therapeutic benefits without generating any damage (4)(5)(6).…”

mentioning

confidence: 99%

Pharmacokinetics and Therapeutic Potential of Milk Thistle Extracted Phytoconstituents: A Leading Role in Cancer Treatment

Rizwan,

Naseem,

Durrani

2023

Trends Med Sci

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: The utilization of natural plants as potent sources for curing chronic diseases has increased researchers' attention toward herbal and nutraceutical treatments. Silymarin, a flavonolignan, is derived from the natural plant milk thistle, Silybum marianum. It is utilized in both clinical and experimental settings to protect against a variety of diseases. Silymarin has only a modest influence on the pharmacokinetics of numerous medicines in vivo. The pharmacokinetics of silymarin indicate that it is readily absorbed and metabolized in phases I and II. Its conjugation can be found in phase II, and it is ultimately eliminated in urine and bile. The main active ingredients, silibinin and silymarin, are protective against cancer in a wide range of tissues. Additionally, it exhibited anti-angiogenic, antioxidant, anti-inflammatory, and anti-metastatic effects. Several types of research have proven the chemopreventive effects of silymarin in both in vivo and in vitro models of tumor development. It could be used as an addition to existing treatments for cancer survivors. This review includes the chemistry of silymarin, mechanistic studies on the potential biological targets of silymarin/silibinin for chemoprevention, several putative molecular pathways, and human clinical trials.

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Mesoporous silica coated SPIONs containing curcumin and silymarin intended for breast cancer therapy

Cited by 8 publications

References 48 publications

Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine

Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine

Nano Parthenolide Improves Intestinal Barrier Function of Sepsis by Inhibiting Apoptosis and ROS via 5-HTR2A

Pharmacokinetics and Therapeutic Potential of Milk Thistle Extracted Phytoconstituents: A Leading Role in Cancer Treatment

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