Mesoporous silica nanoparticle core-shell matrix (MSN CSM) engineered by green approach for pH triggered release of anticancer drugs

Varghese, Sophia; Kumawat, Akshant; Ghoroi, Chinmay

doi:10.1016/j.apt.2022.103830

Cited by 5 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This confirms the successful loading of the drug within NGs. Similar findings were reported by Varghese et al, where such peaks were observed in DOX-loaded MSN particles …”

Section: Resultssupporting

confidence: 92%

“…Similar findings were reported by Varghese et al, where such peaks were observed in DOXloaded MSN particles. 78 Rheological properties of NGs and DNGs are conducted to ascertain the structural stability of the nanogel both before and after loading with DOX. Since the gelation property is defined within the constraints of G′ > G″, the sustainability of NGs remains only up to 15 rad/s, whereas DNGs can maintain their gel property up to 100 rad/s (Figure 6A and 6C).…”

Section: Synthesis and Characterization Of Ngsmentioning

confidence: 99%

See 1 more Smart Citation

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

Kumawat,

Karmakar,

Ghoroi

2024

ACS Appl. Nano Mater.

Self Cite

View full text Add to dashboard Cite

In the realm of colon-based drug delivery, developing a pHresponsive nanocarrier that exhibits significant intrinsic reactive oxygen species (ROS) scavenging activity holds great promise. To address this, a nanogel (NG) is synthesized using itaconic acid (IAc) and acrylamide (AAm) monomers in a molar ratio of 1:4 via free radical polymerization. The spherical NG of size 190 ± 15 nm is confirmed by using field emission scanning electron microscopy (FESEM). Dynamic light scattering (DLS) characterization reveals a hydrodynamic diameter and zeta potential of 271 ± 23 nm and −6.9 ± 2.3 mV, respectively. FTIR, XPS, and NMR analyses confirm the presence of multiple functionalities on the NG. Significant improvement in swelling (10 times) at colonic pH (pH 7.4) in contrast to gastric pH (pH 1.2) ensures the pH-responsive behavior of a NG along with five times higher ROS scavenging activity compared to control. As a model drug, doxorubicin (DOX) is employed to investigate release properties and cellular uptake. The NG exhibited drug loading capacity and efficiency of 26 ± 1.2% and 90 ± 1.3%, respectively, with a three times higher DOX release at pH 7.4 than at pH 1.2. Rheology data reveal the superior structural integrity of the doxorubicin loaded nanogel (DNG) compared to the NG. The biocompatibility of the NG is confirmed through MTT, the hemolysis assay, and cell uptake assays on HCT-116 colon cancer cells. The cellular uptake studies have indicated NG-mediated drug release in the colon microenvironment with subsequent passive diffusion of DOX into cells. These findings underscore the capability of the synthesized NG as a vehicle for oral drug delivery to the colon.

show abstract

“…This confirms the successful loading of the drug within NGs. Similar findings were reported by Varghese et al, where such peaks were observed in DOX-loaded MSN particles …”

Section: Resultssupporting

confidence: 92%

Section: Synthesis and Characterization Of Ngsmentioning

confidence: 99%

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

Kumawat,

Karmakar,

Ghoroi

2024

ACS Appl. Nano Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

“…These nanoparticles exhibit a well-defined porous structure with pore sizes ranging from 2 to 50 nm, offering a high surface area and large pore volume. 1 Mesoporous nanoparticles, including mesoporous silica nanoparticles (MSNs), 2 mesoporous carbon nanoparticles (MCNs), 3 mesoporous metal oxide nanoparticles, 4,5 mesoporous polymer nanoparticles, 6 and mesoporous metal–organic frameworks (MOFs), 7 are a versatile class of materials with well-defined mesoporous structures. These nanoparticles possess high surface area, adjustable pore sizes, and unique properties, rendering them highly suitable for a wide range of application.…”

Section: Introductionmentioning

confidence: 99%

Microstructure, ion adsorption and magnetic behavior of mesoporous γ-Fe₂O₃ ferrite nanoparticles

Nasirpouri,

Fallah,

Ahmadpour

et al. 2023

RSC Adv.

View full text Add to dashboard Cite

show abstract

Carboxymethyl chitosan/polyvinyl alcohol hydrogel films by incorporating MSNs as ε-PL carrier with pH-responsive controlled release and antibacterial properties

Wang,

Fan,

et al. 2024

Food Packaging and Shelf Life

View full text Add to dashboard Cite

Mesoporous silica nanoparticle core-shell matrix (MSN CSM) engineered by green approach for pH triggered release of anticancer drugs

Cited by 5 publications

References 43 publications

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

Microstructure, ion adsorption and magnetic behavior of mesoporous γ-Fe₂O₃ ferrite nanoparticles

Carboxymethyl chitosan/polyvinyl alcohol hydrogel films by incorporating MSNs as ε-PL carrier with pH-responsive controlled release and antibacterial properties

Contact Info

Product

Resources

About

Mesoporous silica nanoparticle core-shell matrix (MSN CSM) engineered by green approach for pH triggered release of anticancer drugs

Cited by 5 publications

References 43 publications

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

Microstructure, ion adsorption and magnetic behavior of mesoporous γ-Fe2O3 ferrite nanoparticles

Carboxymethyl chitosan/polyvinyl alcohol hydrogel films by incorporating MSNs as ε-PL carrier with pH-responsive controlled release and antibacterial properties

Contact Info

Product

Resources

About

Microstructure, ion adsorption and magnetic behavior of mesoporous γ-Fe₂O₃ ferrite nanoparticles